Treatment and prevention of venous thromboembolic complications: focus on sulodexide

DOI: https://doi.org/10.29296/25877305-2024-04-11
Issue: 
4
Year: 
2024

I. Rodionova, Сandidate of Medical Sciences; M. Vinogradova; E. Skvortsova; Professor V. Skvortsov, MD
Volgograd State Medical University, Ministry of Health of Russia

Venous thromboembolic complications (VTEC) are a common pathology that includes pulmonary embolism and deep vein thrombosis of the lower extremities. Modern drug therapy for VTEC includes taking anticoagulants, which reduce the risk of VTEC recurrence to 1–2% of cases. The article discusses the drug sulodexide, which belongs to the class of heparinoids. Sulodexide is a relatively safe drug that has anti-inflammatory and antithrombotic effects, reducing the release of cytokines, chemokines and growth factors, as well as proteinases and degrading enzymes. When taken orally, there is no pharmacological interaction with substances aimed at treating vascular diseases, so it can be prescribed to patients with concomitant diseases.
Keywords: 
sulodexide
venous thromboembolism
safety
hemorrhagic risk
effectiveness.

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