HAC (Russian)
RSCI (Russian)
Ulrichsweb (Ulrich’s Periodicals Directory)
Scientific Indexing Services

Zonulin as a marker of intestinal permeability in patients with acne associated with celiac disease

DOI: https://doi.org/10.29296/25877305-2023-01-13

S. Ledentsova(1), N. Gulyaev(2), MD; Professor S. Klyuchereva(3), MD; Professor
L. Oreshko(3), MD; Associate Professor P. Seliverstov(4), Candidate of Medical Sciences
1-Consultative and Diagnostic Center, Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
2-A.A. Vishnevsky Central Military Clinical Hospital. Ministry of Defense of Russia, Krasnogorsk
3-.I. Mechnikov North-Western State Medical University, Ministry of Health
of Russia, Saint Petersburg
4-S.M. Kirov Military Medical Academy, Ministry of Defense of Russia,
Saint Petersburg

The intestinal barrier plays an important role in maintaining gut and whole body immune homeostasis. The role of the gastrointestinal microbiota is significant in maintaining intestinal tightness as the latter affects the intestinal barrier. Shifting the balance of the gut microbiota composition towards opportunistic microorganisms is known to lead to increased secretion of the recently discovered protein zonulin. The level of zonulin in patients with various diseases makes it possible to judge the change in intestinal wall permeability during pathological processes or different types of therapy. The present study examined for the first time the effect of a gluten-free diet on the course of acne in patients with and without celiac disease. The given study was the first to investigate the effect of a gluten-free diet on the course of acne in patients with and without celiac disease.

celiac disease
gluten-free diet
impaired intestinal microbiocenosis
intestinal permeability

  1. Serek P., Oleksy-Wawrzyniak M. The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity. Int J Mol Sci. 2021; 22 (21): 11359. DOI: 10.3390/ijms222111359
  2. Quigley E.M. Leaky gut – concept or clinical entity? Curr Opin Gastroenterol. 2016; 32 (2): 74–9. DOI: 10.1097/MOG.0000000000000243
  3. Lozupone C.A., Stombaugh J.I., Gordon J.I. et al. Diversity, stability and resilience of the human gut microbiota. Nature. 2012; 489 (7415): 220–30. DOI: 10.1038/nature11550
  4. Khavkin A.I., Bogdanova N.M., Novikova V.P. Biological role of zonulin: a biomarker of increased intestinal permeability syndrome. Rossijskij vestnik perinatologii i pediatrii. 2021; 66 (1): 31–8 (in Russ.). DOI: 10.21508/1027-4065-2021-66-1-31-38
  5. Zybina N.N., Nikonov E.L., Gershtein E.S. et al. Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review). Russian Journal of Evidence-Based Gastroenterology. 2022; 11 (1): 28–44 (in Russ.). DOI: 10.17116/dokgastro20221101128
  6. Drago S., El Asmar R., Di Pierro M. et al. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol. 2006; 41 (4): 408–19. DOI: 10.1080/00365520500235334
  7. Valitutti F., Fasano A. Breaking Down Barriers: How Understanding Celiac Disease Pathogenesis Informed the Development of Novel Treatments. Dig Dis Sci. 2019; 64 (7): 1748–58. DOI: 10.1007/s10620-019-05646-y
  8. Khaleghi S., Ju J.M., Lamba A. et al. The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. Ther Adv Gastroenterol. 2016; 9 (1): 37–49. DOI: 10.1177/1756283X15616576
  9. Hollon J., Puppa E.L., Greenwald B. et al. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients. 2015; 7 (3): 1565–76. DOI: 10.3390/nu7031565
  10. Zhang H., Liao W., Chao W. et al. Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents. J Dermatol. 2008; 35 (9): 555–61. DOI: 10.1111/j.1346-8138.2008.00523.x
  11. Zhang H., Yu L., Yi M. et al. Quantitative studies on normal flora of seborrhoeic dermatitis. Chin J Dermatol. 1999; 32: 399–400.
  12. Volkova L.A., Khalif I.L., Kabanova I.N. Vliyaniye disbakterioza kishechnika na techeniye vul'garnykh ugrey. Klinicheskaya meditsina. 2001; 79 (6): 39–41 (in Russ.).
  13. Vasil'yeva Ye.S., Savost'yanova O.V. Sostoyaniye mikroekologii kishechnika u bol'nykh ugrevoy bolezn'yu. RMJ. 2007; 15 (19): 1398–9 (in Russ.).
  14. Toskes P.P. Bacterial overgrowth of the gastrointestinal tract. Adv Intern Med. 1993; 38: 387–407.
  15. Matushevskaya E.V., Komissarenko I.A. Cutaneous manifestations of diseases of the gastrointestinal tract. Experimental and Clinical Gastroenterology. 2019; 6: 86–92 (in Russ.). DOI: 10.31146/1682-8658-ecg-166-6-86-92
  16. Juhlin L., Michaëlsson G. Fibrin microclot formation in patients with acne. Acta Derm Venereol. 1983; 63 (6): 538–40.
  17. Shinohara K., Ohashi Y., Kawasumi K. et al. Effect of apple intake on fecal microbiota and metabolites in humans. Anaerobe. 2010; 16 (5): 510–5. DOI: 10.1016/j.anaerobe.2010.03.005
  18. Sonnenburg J.L., Bäckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016; 535 (7610): 56–64. DOI: 10.1038/nature18846
  19. Morales P., Fujio S., Navarrete P. et al. Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers. Clin Transl Gastroenterol. 2016; 7 (4): e161. DOI: 10.1038/ctg.2016.20
  20. Sardana K., Sachdeva S. Role of nutritional supplements in selected dermatological disorders: A review. J Cosmet Dermatol. 2022; 21 (1): 85–98. DOI: 10.1111/jocd.14436