Zonulin as a marker of intestinal permeability in patients with acne associated with celiac disease

DOI: https://doi.org/10.29296/25877305-2023-01-13
Issue: 
1
Year: 
2023

S. Ledentsova(1), N. Gulyaev(2), MD; Professor S. Klyuchereva(3), MD; Professor
L. Oreshko(3), MD; Associate Professor P. Seliverstov(4), Candidate of Medical Sciences
1-Consultative and Diagnostic Center, Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia
2-A.A. Vishnevsky Central Military Clinical Hospital. Ministry of Defense of Russia, Krasnogorsk
3-.I. Mechnikov North-Western State Medical University, Ministry of Health
of Russia, Saint Petersburg
4-S.M. Kirov Military Medical Academy, Ministry of Defense of Russia,
Saint Petersburg

The intestinal barrier plays an important role in maintaining gut and whole body immune homeostasis. The role of the gastrointestinal microbiota is significant in maintaining intestinal tightness as the latter affects the intestinal barrier. Shifting the balance of the gut microbiota composition towards opportunistic microorganisms is known to lead to increased secretion of the recently discovered protein zonulin. The level of zonulin in patients with various diseases makes it possible to judge the change in intestinal wall permeability during pathological processes or different types of therapy. The present study examined for the first time the effect of a gluten-free diet on the course of acne in patients with and without celiac disease. The given study was the first to investigate the effect of a gluten-free diet on the course of acne in patients with and without celiac disease.
Keywords: 
gastroenterology
dermatology
acne
celiac disease
zonulin
gluten-free diet
impaired intestinal microbiocenosis
intestinal permeability

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