The use of probiotics in the combination treatment of patients with moderate acne

DOI: https://doi.org/10.29296/25877305-2022-07-08
Issue: 
7
Year: 
2022

Professor S. Klyuchereva(1), MD; S. Ledentsova(2); Professor L. Radchenko(3), MD; Associate Professor P. Seliverstov(3, 4), Candidate of Medical Sciences
1-I.I. Mechnikov North-Western State Medical University, Ministry of Health
of Russia, Saint Petersburg
2-City Polyclinic Seventy-Six, Ministry of Health of Russia, Saint Petersburg
3-S.M. Kirov Military Medical Academy, Ministry of Defense of Russia; Saint Petersburg
4-V.A. Almazov National Medical Research Center, Ministry of Health of Russia, Saint Petersburg

Acne is one of the most common skin diseases. Modern treatment regimens for this disease include, among other things, antibacterial drugs (ABP) for up to 8 weeks. However, the prescription of ABP entails the development of intestinal microbiocenosis disorders that can aggravate the course of the underlying disease. As far back as the 1930s, the gastroenterological mechanisms involved in the relationship between the status of the intestine and skin diseases were first stated, as well as it was also proposed to use probiotic cultures in the therapy of acne. In addition, modern researches have confirmed the aspects of the gut-brain-skin theory. Thus, the intestinal microflora and oral probiotics can be associated with the skin and, in particular, with the severity of acne due to their ability to influence systemic inflammation, oxidative stress, glycemic control, lipid content in tissues, etc. Our investigation shows the effectiveness of prescribing a probiotic in the treatment of moderate acne in patients taking doxycycline.
Keywords: 
dermatology
therapy
acne
probiotic
doxycycline
impaired intestinal microbiocenosis

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