Risk for folate-dependent congenital malformations upon preconception exposure to medicines: the impact of ABCB1 gene polymorphism
DOI: https://doi.org/10.29296/25877305-2022-04-12
Issue:
4
Year:
2022
The results of numerous studies demonstrate the heterogeneity of the causes of congenital malformations (CMs) (genetic, chromosomal, teratogenic, etc.), although the nature of CMs remains unknown and is multifactorial in a significant proportion (65–70%) of cases. At least 2–3% of all СMs are known to be associated with the use of drugs.
The paper gives the results of the authors’ own study evaluating the impact of ABCB1 gene polymorphism on the risk of CMs in the Russian population of pregnant women.
Keywords:
intrauterine malformations
ABCB1 gene polymorphism
folate-dependent abnormalities
folate-independent abnormalities
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