Impact of magnetic therapy on cognitive functions and emotional background in elderly and senile patients


Associate Professor I. Zueva(1), MD; Professor D. Medvedev(2, 3), MD; Associate Professor S. Maltsev(1), Candidate of Medical Sciences; Associate Professor
S. Makarenko(1), Candidate of Medical Sciences; I. Yushkova1, Candidate of Biological Sciences; D. Trotsyuk(1, 4); Yu. Kim(5); Associate Professor N. Linkova(4), Biol.D
1-Saint Petersburg Medical and Social Institute
2-I.I. Mechnikov North-Western State Medical University, Ministry of Health
of Russia, Saint Petersburg
3-Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Biomedical Agency of Russia, Saint Petersburg
4-Belgorod State National Research University,
5-I.P. Pavlov First Saint Petersburg University

Due to the high prevalence of dementia in older age groups, a search is underway for effective and safe treatments for cognitive impairment (CI). Objective: to study the impact of magnetic therapy on cognitive functions (CF), sleep, and anxiety in elderly and senile patients. Subjects and methods. The investigation enrolled 60 elderly and senile patients (27 males; 33 females; mean age, 76.2±9.4 years). According to preliminary neuropsychological tests, the patients were divided into 3 groups: 1) mild CI; 2) moderate CI; and 3) mild dementia. The patients in each group were also randomized to 2 subgroups of 10 people: a no-treatment control group and a magnetic therapy study group. Magnetic therapy was performed using the Almag-03. The therapy cycle involved fourteen 15-20-minute sessions for 14 days. After 14 days, neuropsychological tests were carried out in the control and study groups. Results. After a magnetic therapy cycle, the clock drawing test and the Luria “10 words” test showed that their scores in Group 1 patients increased by 15 and 24%, respectively, as compared to those in the control subgroup. These tests in Group 2 indicated that magnetic therapy caused a rise in the number of scores by 45 and 28%, respectively, compared to those in the control subgroup. Magnetic therapy had no impact on CF in Group 3 patients. After magnetic therapy, the patients of all the study groups showed a significant sleep improvement by 9, 7 and 8%, respectively, compared to the control subgroup. In Group 3 patients, magnetic therapy decreased the number of geriatric depression scale scores by 19% compared to that in the control subgroup. After a magnetic therapy cycle, in Groups 2 and 3 patients anxiety decreased by 32 and 21%, respectively, compared to the control subgroup. Conclusion. Patients over 65 years of age who had mild to moderate CI were found to have better CF and sleep quality and decreased anxiety after magnetic therapy. The latter is a promising treatment option for elderly and senile patients with cognitive impairment and emotional disorders.

magnetic therapy
cognitive impairment
elderly and senile age

  1. Ellul M.A., Benjamin L., Singh B. et al. Neurological associations of COVID-19. Lancet Neurol. 2020; 19 (9): 767–83. DOI: 10.1016/S1474-4422(20)30221-0
  2. Koralnik I.J., Tyler K.L. COVID-19: A global threat to the nervous system. Ann Neurol. 2020; 88 (1): 1–11. DOI: 10.1002/ana.25807
  3. Begemann M.J., Brand B.A., Ćurčić-Blake B. et al. Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis. Psychol Med. 2020; 50 (15): 2465–86. DOI: 10.1017/S0033291720003670
  4. Mimura Y., Nishida H., Nakajima S. et al. Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2021; 121: 47–59. DOI: 10.1016/j.neubiorev.2020.12.003
  5. Rajji T.K. Transcranial Magnetic and Electrical Stimulation in Alzheimer's Disease and Mild Cognitive Impairment: A Review of Randomized Controlled Trials. Clin Pharmacol Ther. 2019; 106 (4): 776–80. DOI: 10.1002/cpt.1574
  6. Zhu X.C., Yu Y., Wang H.F. et al. Physiotherapy intervention in Alzheimer's disease: systematic review and meta-analysis. J Alzheimers Dis. 2015; 44 (1): 163–74. DOI: 10.3233/JAD-141377
  7. Iriarte I.G., George M.S. Transcranial Magnetic Stimulation (TMS) in the Elderly. Curr Psychiatry Rep. 2018; 20 (1): 6. DOI: 10.1007/s11920-018-0866-2
  8. Dai L., Wang P., Zhang P. et al. The therapeutic effect of repetitive transcranial magnetic stimulation in elderly depression patients. Medicine (Baltimore). 2020; 99 (32): e21493. DOI: 10.1097/MD.0000000000021493
  9. Gumarova L.Sh., Bodrova R.A., Khasanova D.R. et al. Clinical effectiveness of «thresholdless» low-frequency transcranial magnetic stimulation in patients with ischemic stroke. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kultury. 2020; 97 (5): 39–44 (in Russ.). DOI: 10.17116/kurort20209705139
  10. Maksimov A.V., Kiryanova V.V., Maksimova M.A. The therapeutic application of magnetic fields. Fizioterapiya, bal'neologiya i reabilitaciya. 2013; 3: 34–9 (in Russ.).
  11. Belopasova A.V., Kadykov A.S., Chervyakov A.V. et al. Diagnostic and therapeutic potential of transcranial magnetic stimulation in aphasic patients. Nevrologicheskij zhurnal. 2015; 4: 23–8 (in Russ.).
  12. Stilling J.M., Monchi O., Amoozegar F. et al. Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review. Headache. 2019; 59 (3): 339–57. DOI: 10.1111/head.13479
  13. Kayser S., Bewernick B.H., Wagner S. et al. Effects of magnetic seizure therapy on anterograde and retrograde amnesia in treatment-resistant depression. Depress Anxiety. 2020; 37 (2): 125–33. DOI: 10.1002/da.22958
  14. Meditsina sna. Izbrannye lektsii po nevrologii. Pod red. V.L. Golubeva M.: Eidos Media, 2006; 624 p. (in Russ.).
  15. Cooper L.L., Woodard T., Sigurdsson S., et al. Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory. Hypertension. 2016; 67 (1): 176–82. DOI: 10.1161/HYPERTENSIONAHA.115.06398
  16. Daulatzai M.A. Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease. J Neurosci Res. 2017; 95 (4): 943–72. DOI: 10.1002/jnr.23777
  17. Fulop G.A., Tarantini S., Yabluchanskiy A. et al. Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2019; 316 (5): H1124–H1140. DOI: 10.1152/ajpheart.00776.2018
  18. Gilmutdinova L.T., Iseeva D.R., Yamilova G.T. et al. Application of the general magnetotherapy in regenerative treatment of patients with dyscirculatory encephalopathy. Fundamental'nye issledovaniya. 2012; 7–1: 71–5 (in Russ.).
  19. Rakhmanova A.A., Skorokhodov A.P., Kutashov V.A. Evaluation of the effectiveness of the method of treatment of cognitive disorders with the integrated use of transcranial magnetic stimulation in ischemic stroke patients in the late recovery period. Farmateka. 2020; 27 (13): 108–13 (in Russ.). DOI: 10.18565/pharmateca.2020.13.108-113