Folate-dependent congenital malformations and ABCB1 gene polymorphism

DOI: https://doi.org/10.29296/25877305-2022-03-08
Issue: 
3
Year: 
2022

T. Pikuza(1); Professor R. Chilova(1), MD; Associate Professor E. Sokova(1, 2), Candidate of
Medical Sciences, R. Kazakov(2), Candidate of Biological Sciences; E. Zhukova(1), Candidate of Medical
Sciences; N. Trifonova(1), Candidate of Medical Sciences; Professor E. Shikh(1), MD (1)I.M. Sechenov First
Moscow State Medical University (Sechenov University), Ministry of Health of Russia (2)Research Center for
Examination of Medical Products, Ministry of Health of Russia, Moscow

The high frequency of embryonic and fetal losses is caused by congenital malformations (CMFs). The significant contribution of CMFs to the structure of causes of infant deaths, diseases, and disability define their important medical and social values. The paper gives the results of the authors’ own study on the effect of ABCB1 gene polymorphism on the risk of congenital CMFs in the Russian population of pregnant women.
Keywords: 
congenital malformations
folate-dependent abnormalities
ABCB1 gene polymorphism

References: 
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