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Clinical rationale for the use of autologous platelet-rich plasma during cesarean section

DOI: https://doi.org/10.29296/25877305-2022-01-08
Issue: 
1
Year: 
2022

Z. Mazhidova; Professor A. Yashchuk, MD; Associate Professor I. Musin, Candidate of Medical
Sciences Bashkir State Medical University, Ministry of Health of Russia, Ufa

The use of autologous platelet-rich plasma (aPRP) is one of the modern methods to model tissue regeneration, which promotes acceleration of scar formation, activation of collagenization and angiogenesis, and maturation of connective tissue. Objective. To evaluate the therapeutic efficiency of intraoperative aPRP use for intensifying the mechanism of reparative wound regeneration after cesarean section (CS). Subjects and methods. Fifty pregnant women who had undergone surgical delivery participated in the investigation. During the latter, the patients were randomized into 2 groups according to the type of surgery: 1) standard CS; 2) CS using aPRP. Clinical, laboratory, and instrumental studies were applied. Results. The incorporation of aPRP during CS has been shown to be an easy-to-use method that does not increase the duration of surgical therapy and significantly reduces blood loss by 26.3% (p>0.05). The use of aPRP in the early stages of CS is accompanied by a decrease in peripheral vascular resistance and by an improvement in blood flow, which leads to the stimulation of wound regenerative processes, to the intensification of angiogenesis, to the acceleration of tissue remodeling, to a reduction in the phase of wound healing, and, as a result, to a lower incidence of pyoseptic complications. Conclusion. aPRP can be used during CS to reduce the risk of pyoseptic complications and to create an optimal and adequate uterine scar.

Keywords: 
obstetrics and gynecology
surgery
cesarean section
autologous platelet-rich plasma
blood flow
wound
pyoseptic complications



References: 
  1. Ryzhkov V.V., Hazhbiev A.A. Profilaktika gnojno-septicheskih oslozhnenij posle operatsii kesareva sechenija. Tavricheskij mediko-biologicheskij vestnik. 2017; 20 (2-2): 190–7 [Ryzhkov V.V., Khazhbiev A.A. Prevention of purulent-septic complications after cesarean section. Tavricheskii mediko-biologicheskii vestnik. 2017; 20 (2-2): 190–7 (in Russ.)]. URL: https://cyberleninka.ru/article/n/profilaktika-gnoyno-septicheskih-oslozhneniy-posle-operatsii-kesareva-secheniya
  2. Zuarez-Easton S., Zafran N., Garmi G. et al. Postcesarean wound infection: prevalence, impact, prevention, and management challenges. Int J Womens Health. 2017; 9: 81–8. DOI: 10.2147/IJWH.S98876
  3. Tshaj V.B., Platonova L.N., Ganzhurov A.B. i dr. Primenenie lechebno-profilakticheskih tehnologij s tsel'ju snizhenija gnojno-septicheskih oslozhnenij posle operatsii kesarevo sechenija. Sibirskij meditsinskij zhurnal (Irkutsk). 2001; 29 (5): 5–10 [Tshaj V.B., Platonova L.N., Gandzurov A.B. et al. The use of treatment and prophylactic technologies to reduce infectious - septic complications after cesarean section. Sibirskii meditsinskii zhurnal (Irkutsk). 2001; 29 (5): 5–10 (in Russ.)]. URL: https://cyberleninka.ru/article/n/primenenie-lechebno-profilakticheskih-tehnologiy-s-tselyu-snizheniya-gnoyno-septicheskih-oslozhneniy-posle-operatsii-kesarevo
  4. Zejnullahu V.A., Isjanovska R., Sejfija Z. et al. Surgical site infections after cesarean sections at the University Clinical Center of Kosovo: rates, microbiological profile and risk factors. BMC Infect Dis. 2019; 19 (1): 752. DOI: 10.1186/s12879-019-4383-7
  5. Kramarskij V. A., Dudakova V. N. Osobennosti zazhivlenija rany na matke posle kesareva sechenija u rodil'nits vysokoj stepeni riska gnojno-septicheskih oslozhnenij. Sibirskij meditsinskij zhurnal (Irkutsk). 2009; 85 (2): 6–8 [Kramarskij V.A., Dudakova V.N. Features of healing of a wound on a uterus after cesarean sections in women with high degree of risk of septic complications. Sibirskii meditsinskii zhurnal (Irkutsk). 2009; 85 (2): 6–8 (in Russ.)]. URL: https://cyberleninka.ru/article/n/osobennosti-zazhivleniya-rany-na-matke-posle-kesareva-secheniya-u-rodilnits-vysokoy-stepeni-riska-gnoyno-septicheskih-oslozhneniy
  6. Saeed K.B., Greene R.A., Corcoran P. et al. Incidence of surgical site infection following caesarean section: a systematic review and meta-analysis protocol. BMJ Open. 2017; 7 (1): e013037. DOI: 10.1136/bmjopen-2016-013037
  7. Jaschuk A.G., Musin I.I., Berg E.A. i dr. Vrastanie platsenty. Uchebno-metod. posob. dlja studentov meditsinskih VUZov. Ufa: Izdatel'stvo «Zdravoohranenie Bashkortostana», 2021; 80 s. [Yaschuk A.G., Musin I.I., Berg E.A. et al. Placenta ingrowth. Ufa: Publishing house «Healthcare of Bashkortostan», 2021; 80 r. (in Russ.)]
  8. Egorova A.T., Glebova T.K., Maiseenko D.A. i dr. Gnojno-vospalitel'nye oslozhnenija v akusherskoj praktike po materialam kraevoj klinicheskoj bol'nitsy g. Krasnojarska. Sibirskoe meditsinskoe obozrenie. 2015; 4: 47–51 [Egorova A.T., Glebova T.K., Maiseenko D.A. et al. Pyoinflammatory complications in obstetric practice according to the materials of the regional clinical hospital of Krasnoyarsk. Siberian Medical Review. 2015; 4: 47–51 (in Russ.)]. URL: https://cyberleninka.ru/article/n/gnoyno-vospalitelnye-oslozhneniya-v-akusherskoy-praktike-po-materialam-kraevoy-klinicheskoy-bolnitsy-g-krasnoyarska
  9. Musin I.I., Jaschuk A.G., Maslennikov A.V., i dr. Opyt hirurgicheskogo gemostaza vo vremja kesareva sechenija. Vestnik Smolenskoj gosudarstvennoj meditsinskoj akademii. 2018; 17 (1): 120–5 [Musin I.I., Yaschuk A.G., Maslennikov A.V. et al. Experience of surgical hemostasis during cesarean section. Vestnik of the Smolensk State Medical Academy. 2018; 17 (1): 120–5 (in Russ.)].