Prospects and possibilities of using a fixed combination of a solid dosage form of paracetamol and tramadol in traumatology (postoperative period)
DOI: https://doi.org/10.29296/25877305-2021-12-13
Issue:
12
Year:
2021
Objective: to evaluate the effectiveness of postoperative analgesia with a fixed combination of
paracetamol 325 mg + tramadol 37.5 mg in trauma patients over 18 years of age with moderate and high
intensity pain syndrome (PS). Subjects and methods. The study included 60 traumatological patients in the
early postoperative period with PS aged over 18 years. Postoperative anesthesia was carried out from the
first day with a fixed combination of Paracetamol + Tramadol (Organicа) film-coated tablets 325 mg + 37.5
mg. Daily and single doses were selected individually, according to the instructions. The anesthesia regimen
varied in taking a fixed combination of paracetamol and tramadol: 1 tablet from 1 to 4 times a day or 2
tablets 4 times a day. Pain assessment before and after anesthesia was carried out according to the visual
analog scale (VAS) of pain intensity. Results and discussion. The duration of anesthesia varied from 1 to 5
days depending on the pathology and averaged 2.9 days. The groups did not differ statistically by gender,
age and concomitant pathology. The male sex prevailed in the trauma departments. The average age of patients
was 48.75 years. In 100% of cases, effective anesthesia was observed – according to VAS, the score values
after taking the painkiller in three centers varied from 0 to 3. The results of the study showed
statistically significant differences in the score values on the VAS scale before and after taking the
painkiller in three centers. The average score on the pain scale VAS before taking the painkiller was 6.400
in 1 center, 6.440 in 2 center and 6.467 in 3 center, after taking the painkiller – 1.650 (p=0.0012), 1.48
(p=0.0004) and 1.333 (p=0.0078), respectively. Side effects when using a fixed combination of paracetamol
and tramadol (in the recommended maximum daily dosages of tramadol up to 400 mg): dizziness, nausea,
vomiting, were not observed in patients in this study. Hypotension was observed in two patients (3.45% of
the sample size) aged over 70 years while taking painkiller, the manifestation of which was stopped by
intravenous administration of dexamethasone. Conclusions. The results of the study indicate that the fixed
combination of Paracetamol 325 mg + Tramadol 37.5 mg produced by АО «Organica» (Novokuznetsk) allows for
effective and safe therapy of moderate and high intensity PS and is an effective alternative to invasive
medicinal forms of painkillers, while achieving a significant reduction in the side effects of the active
components included in its composition.
Keywords:
surgery
traumatology
postoperative period
pain syndrome
tramadol
combined drug Paracetamol + Tramadol
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