COVID-19 AND PNEUMOCYSTIS PNEUMONIA IN A PATIENT WITH HIV INFECTION
DOI: https://doi.org/10.29296/25877305-2021-11-07
Issue:
11
Year:
2021
Changes in lung tissue like ground-glass opacities are typical for many lung diseases, but in
modern conditions, the main diagnosis in identifying increasing respiratory symptoms with a change on CT is
the diagnosis «New coronavirus infection COVID-19, Bilateral polysegmental viral pneumonia”. The existing
danger of «missing» another diagnosis is very high. Opportunities for high-quality differential diagnostics
are significantly reduced. The aim is to show a clinical example of the comorbidity of a viral infection in
a patient with HIV infection with severe immunodeficiency. Materials and methods. The clinical example from
the practice of the COVID-19 is presented. Results. In a patient with a typical course of COVID-19, negative
dynamics appeared during long-term treatment on day 37. Examination revealed an increase in symptoms and
lung damage up to 85%. Further examination revealed HIV infection for the first time, confirmed by
immunoblot at the stage of severe immunodeficiency (CD4 20 cells/μl). Pneumocystis pneumonia has been
diagnosed. The patient died, although the treatment was carried out in full. Conclusion. During the COVID-19
pandemic, there is the possibility of a comorbid COVID-19 disease and other diseases that also have a
ground-glass opacities.
Keywords:
infectious diseases
COVID-19
ground-glass opacities
Pneumocystis pneumonia
immunodeficiency
HIV infection
References:
- Wang D., Hu B., Hu C. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020; 323 (11): 1061–9. DOI: 10.1001/jama.2020.1585
- Huang C., Wang Y., Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497–506. DOI: 10.1016/S0140-6736(20)30183-5
- Rigamonti E., Salera D., Gheorghiu A.C. et al. The many faces of interstitial pneumonia: a case of presumed SARS-CoV-2 infection. Swiss Med Wkly. 2020; 150: w20312. DOI: 10.4414/smw.2020.20312
- Zieda A., Sbardella S., Patel M. et al. Diagnostic Bias in the COVID-19 Pandemic: A Series of Short Cases. Eur J Case Rep Intern Med. 2021; 8 (5): 002575. DOI: 10.12890/2021002575
- Korb T.A., Gavrilov P.V., Chernina V.Ju. i dr. Spetsifichnost' komp'juternoj tomografii organov grudnoj kletki pri pnevmonii, assotsiirovannoj s COVID-19: retrospektivnoe issledovanie. Al'manah klinicheskoj meditsiny. 2021; 49 (1): 1–10 [Korb T.A., Gavrilov P.V., Chernina V.Yu. et al. Specificity of chest computed tomography in COVID-19-associated pneumonia: a retrospective study. Almanac of Clinical Medicine. 2021; 49 (1): 1-10 (in Russ.)]. DOI: 10.18786/2072-0505-2021-49-001
- Borodulina E.A., Jakovleva E.V., Povaljaeva L.V. i dr. Sravnitel'noe issledovanie gepsidina syvorotki krovi patsientov s porazheniem legkih pri COVID-19 i pnevmotsistnoj pnevmonii. Klinicheskaja laboratornaja diagnostika. 2021; 66 (11): 645–9 [Borodulina E.A., Yakovleva E.V., Povalyaeva L.V. et al. Comparative study of the serum hepcidin level of patients with pneumonia in COVID-19 and Pneumocystis pneumonia. Klinicheskaya laboratornaya diagnostika. 2021; 66 (11): 645–9 (in Russ.)]. DOI: 10.51620/0869-2084-2021-66-11-645-649
- Kudlaj D.A., Shirobokov Ja.E., Gladunova E.P. i dr. Diagnostika COVID-19. Sposoby i problemy obnaruzhenija virusa SARS-COV-2 v uslovijah pandemii. Vrach. 2020; 31 (8): 5–10 [Kudlay D., Shirobokov YA., Gladunova E. et al. Diagnosis of COVID-19. Methods and problems of virus SARS-COV-2 detection under pandemic conditions. Vrach. 2020; 31 (8): 5–10 (in Russ.)]. DOI: 10.29296/25877305-2020-08-01
- Shi H., Han X., Jiang N., et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020; 20 (4): 425–34. DOI: 10.1016/S1473-3099(20)30086-4
- Zhao W., Zhong Z., Xie X. et al. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicenter study. Am J Roentgenol. 2020; 214 (5): 1072–7. DOI: 10.2214/AJR.20.22976
- Gudima G.O., Haitov R.M., Kudlaj D.A. i dr. Molekuljarno-immunologicheskie aspekty diagnostiki, profilaktiki i lechenija koronavirusnoj infektsii. Immunologija. 2021; 42 (3): 198–210 [Gudima G.O., Khaitov R.M., Kudlay D.A. et al. Molecular immunological aspects of diagnostics, prevention and treatment of coronavirus infection. Immunologiya. 2021; 42 (3): 198–210 (in Russ.)]. DOI: 10.33029/0206-4952-2021-42-3-198-210
- Borodulina E.A., Shirobokov Ja.E., Gladunova E.P. i dr. Diagnostika i farmakoterapija virus-assotsiirovannyh porazhenij legkih. Klinicheskaja farmakologija i terapija. 2020; 29 (3): 61–6 [Borodulina E., Shirobokov Y., Gladunova E. et al. Virus-associated lung disease. Clinical pharmacology and therapy. 2020; 29 (3): 61–6 (in Russ.)]. DOI: 10.32756/0869-5490-2020-3-61-66
- Choy C.Y., Wong C.S. It’s not all about COVID-19: pneumocystis pneumonia in the era of a respiratory outbreak. J Int AIDS Soc. 2020; 23 (6): e25533. DOI: 10.1002/jia2.25533
- Kelly S., Waters L., Cevik M. et al. Pneumocystis pneumonia, a COVID-19 mimic, reminds us of the importance of HIV testing in COVID-19. Clin Med (Lond). 2020; 20 (6): 590–2. DOI: 10.7861/clinmed.2020-0565
- Sajjad M.M., Yousaf S., Ullah S. A Diagnostic Challenge in COVID-19 Pandemic: PCP or COVID-19. J Coll Physicians Surg Pak. 2020; 30 (10): 144. DOI: 10.29271/jcpsp.2020.supp2.144
- Bhat P., Noval M., Doub J.B. et al. Concurrent COVID-19 and Pneumocystis jirovecii pneumonia in a severely immunocompromised 25-year-old patient. Int J Infect Dis. 2020; 99: 119–21. DOI: 10.1016/j.ijid.2020.07.061
- Aver'janov A.V., Sotnikova A.G., Lesnjak V.N. Pnevmotsistnaja pnevmonija, mimikrirujuschaja pod COVID-19. Klinicheskaja praktika. 2020; 11 (2): 87–92 [Averyanov A.V., Sotnikova A.G., Lesnyak V.N. Pneumocystis Pneumonia Mimicking COVID-19. Journal of Clinical Practice. 2020; 11 (2): 87–92 (in Russ.)]. DOI: 10.17816/clinpract34995 Broadhurst A.G.B., Lalla U., Taljaard J.J. et al. The diagnostic challenge of pneumocystis pneumonia and COVID-19 co-infection in HIV. Respirol Case Rep. 2021; 9 (4): e00725. DOI: 10.1002/rcr2.725