Results of comparative metabolic analysis of topical drug formulations of methylprednisolone aceponate in vivo
DOI: https://doi.org/10.29296/25877305-2021-07-15
Issue:
7
Year:
2021
Methylprednisolone aceponate (MPA) is the latest glucocorticosteroid molecule developed for topical
use, having advantageous ratio of safety and efficacy. Peculiarity of MPA is it’s biotransformation after
the application when primary MPA is transformed into more active metabolite methylprednisolone 17-propionate
(17-MPP). This ensue the definition of metabolic profile – cutaneous concentration of 17-MPP after the
application and MPA/17-MPP ratio (metabolic index). After the patent expiration appeared generic MPA drugs
which didn’t pass through the full cycle of clinical trials. Metabolic profile of these generics and it’s
equivalence to the original product is unknown. In the frames of this research the detection of MPA and it’s
active metabolite 17-MPP after the application to the skin of laboratory animals (mini-pigs) was performed
via HPLC-MS at several time-points. It was elicited that maximum 17-MPP concentration corresponds to maximum
concentration of MPA, thus reflecting the correlation between cutaneous concentration of major metabolite
and MPA local transformation. The absolute maximum of 17-MPP concentration and metabolic index was observed
for the original drug Advantan® cream 0.1%, overwhelming same parameters for generic cream. This may be the
result of differences in vehicles. The elicited metabolic profile differences potentially can question the
equivalence of the original drug and generics.
Keywords:
dermatology
pharmacology
methylprednisolone aceponate
methylprednisolone propionate
Advantan®
referent drug
generic
metabolic profile
metabolic index
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