Bioimpedance analysis as a promising screening technology in children
DOI: https://doi.org/10.29296/25877305-2021-07-05
Issue:
7
Year:
2021
Objective: to develop a method for early non-invasive diagnosis of insulin resistance (IR) in
pediatric practice. Subjects and methods. The investigation involved 1,939 children and adolescents who were
divided into 2 age strata: under 10 years (n=625) and 10 years and older (n=1314). Each examinee underwent a
set of clinical and metabolic studies, which included anthropometric measurements, by calculating the body
mass index standard deviation score, bioimpedancometry with the determination of the main indicators of the
body composition. In a random sample of 1859 examinees, serum insulin and glucose levels were determined, by
estimating the homeostasis model assessment index of IR (HOMA-IR), C-peptide, leptin, and lipid spectrum. A
correlation analysis was carried out to search for relationships between the studied bioimpedancometric
parameters and metabolic status. ROC analysis was used to calculate the threshold visceral fat area values
associated with a high risk for IR. Results. The statistical analysis revealed the threshold values of
visceral fat area for bioimpedancometry, which were associated with the risk of IR. The obtained procedure
had the sensitivity and specificity, which were comparable to those of the HOME index. Conclusion.
Application of bioimpedancometry as a screening method for identifying a risk group among children and
adolescents with different body weights will be able to implement timely therapeutic and preventive
measures.
Keywords:
pediatrics
childhood obesity
insulin resistance
bioimpedancometry
visceral obesity
References:
- Di Cesare M., Sorić M., Bovet P. et al. The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action. BMC Med. 2019; 17 (1): 212. DOI: 10.1186/s12916-019-1449-8
- World Health Organization (WHO). Obesity and overweight. URL: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
- World Health Organization (WHO). Nutrition: Global Targets 2025. Geneva: WHO, 2018. URL: http://www.who.int/nutrition/global-target-2025/en/
- World Health Organization (WHO). Global Action Plan for the Prevention and Control of NCDs 2013–2020. Geneva: WHO, 2015. URL: http://www.who.int/nmh/events/ncd_action_plan/en/
- Dahkil'gova H.T Detskoe ozhirenie: sovremennoe sostojanie problemy. Voprosy detskoj dietologii. 2019; 17 (5): 47–53 [Dakhkilgova Kh.T. Childhood obesity: the current state of the problem. Vopr det dietol. (Pediatric Nutrition). 2019; 17 (5): 47–53 (in Russ.)]. DOI: 10.20953/1727-5784-2019-5-47-53
- Quek Y.-H., Tam W.W.S., Zhang M.W.B. et al. Exploring the association between childhood and adolescent obesity and depression: a meta-analysis. Obes Rev. 2017; 18: 742–54. DOI: 10.1111/obr.12535
- Faienza M.F., Chiarito M., Molina-Molina E. et al. Childhood obesity, cardiovascular and liver health: a growing epidemic with age. World J Pediatr. 2020; 16 (5): 438–45. DOI: 10.1007/s12519-020-00341-9
- Weihrauch-Blüher S., Schwarz P., Klusmann J.-H. Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood. Metabolism. 2019; 92: 147–52. DOI: 10.1016/j.metabol.2018.12.001
- Otto N.Ju., Sagitova G.R., Nikulina N.Ju. i dr. Chastota metabolicheskogo sindroma i drugih oslozhnenij ozhirenija v praktike detskogo endokrinologa. Vestnik volgogradskogo gosudarstvennogo meditsinskogo universiteta. 2018; 67 (3): 93–8 [Otto N.YU., Sagitova G.R., Nikulina N.YU. et al. Frequency of metabolic syndrome and other complications of obesity in practice of a child endocrinologist. Vestnik volgogradskogo gosudarstvennogo meditsinskogo universiteta. 2018; 67 (3): 93–8 (in Russ.)]. DOI: 10.19163/1994-9480-2018-3(67)-93-98
- Merder-Coşkun D., Uzuner A., Keniş-Coşkun Ö. et al. Relationship between obesity and musculoskeletal system findings among children and adolescents. Turk J Phys Med Rehabil. 2017; 63 (3): 207–14. DOI: 10.5606/tftrd.2017.422
- Abdullah A., Wolfe R., Stoelwinder J.U. et al. The number of years lived with obesity and the risk of all-cause and cause-specific mortality. Int J Epidemiol. 2011; 40: 985–96. DOI: 10.1093/ije/dyr018
- Park M.H., Falconer C., Viner R.M. et al. The impact of childhood obesity on morbidity and mortality in adulthood: a systematic review. Obes Rev. 2012; 13: 985–1000. DOI: 10.1111/j.1467-789X.2012.01015.x
- Tremmel M., Gerdtham U.-G., Nilsson P.M. et al. Economic burden of obesity: a systematic literature review. Int J Environ Res Public Health. 2017; 14: 435. DOI: 10.3390/ijerph14040435
- Simmonds M., Burch J., Llewellyn A. et al. The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: a systematic review and meta-analysis. Health Technol Assess. 2015; 19 (43): 1–336. DOI: 10.3310/hta19430
- Simmonds M., Llewellyn A., Owen C.G. et al. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016; 17: 95–107. DOI: 10.1111/obr.12334
- Mamaev A.N., Kudlaj D.A. Statisticheskie metody v meditsine. M.: Prakticheskaja meditsina, 2021; 136 s. [Mamaev A.N., Kudlay D.A. Statisticheskie metody v meditsine. M.: Prakticheskaya meditsina, 2021; 136 r. (in Russ.)].
- Samojlova Ju.G., Kudlaj D.A., Podchinenova D.V. i dr. Bioimpedansmetrija kak metod diagnostiki vistseral'nogo ozhirenija v pediatricheskoj praktike. Molekuljarnaja meditsina. 2019; 6: 26–31 [Samoilova Iu.G., Kudlay D.A., Podchinenova D.V. et al. Bioimpendancemetria as a method for diagnosis of visceral obesity in pediatric practice. Molekulyarnaya meditsina. 2019; 17 (6): 26–31 (in Russ.)]. DOI: 10.29296/24999490-2019-06-05
- Graf C., Ferrari N. Metabolic Syndrome in Children and Adolescents. Visc Med. 2016; 32 (5): 357–62. DOI: 10.1159/000449268
- Harrell J.S., Jessup A., Greene N. Changing our future: obesity and the metabolic syndrome in children and adolescents. J Cardiovasc Nurs. 2006; 21: 322–30. DOI: 10.1097/00005082-200607000-00014
- Osmanov E.M., Man'jakov R.R., Osmanov R.E. i dr. Meditsina 4 «P» kak osnova novoj sistemy zdravoohranenija. Vestnik rossijskih universitetov. Matematika. 2017; 22 (6–2): 1680–5 [Osmanov E.M., Manyakov R.R., Osmanov R.E. et al. 4 «P» medicine as a basis of new system of public health. Vestnik rossiiskikh universitetov. Matematika. 2017; 22 (6–2): 1680–5 (in Russ.)]. DOI: 10.20310/1810-0198-2017-22-6-1680-1685
- Podchinenova D.V., Samojlova Ju.G., Kobjakova O.S. i dr. Optimizatsija algoritma profilaktiki i rannej diagnostiki metabolicheskogo sindroma i ego prediktorov. Ural'skij meditsinskij zhurnal. 2019; 11 (179): 51–5 [Podchinenova D.V., Samoilova Yu.G., Kobyakova O.S. et al. Optimization of the algorithm for the prevention and early diagnosis of metabolic syndrome and its predictors. Ural’skii meditsinskii zhurnal. 2019; 11 (179): 51–5 (in Russ.)]. DOI: 10.25694/URMJ.2019.12.11