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DOI: https://doi.org/10.29296/25877305-2021-05-09

Associate Professor Ya. Kozlova, Candidate of Medical Sciences; A. Uchevatkina, Candidate of
Medical Sciences; L. Filippova, Candidate of Medical Sciences; O. Aak, Candidate of Chemical Sciences; V.
Kuznetsov; E. Frolova, Candidate of Medical Sciences; Professor N. Vasilyeva, Biol. Dr.; Professor N.
Klimko, MD North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg

Objective: To evaluate the effect of sensitization to Aspergillus spp. the severity and level of control of asthma. Materials and methods: 275 patients with allergic asthma were examined. The levels of total IgE and specific IgE to aeroallergens were determined in the blood serum by the enzyme immunoassay method. Anamnesis, objective examination, and spirometry data were analyzed to assess the reversibility of the obstruction. The Russian-language version of the questionnaire was used: the Asthma Control Test (Asthma Control Test) The data obtained were processed using the Statistica 10 software system. Results: In patients with asthma with sensitization to Aspergillus spp. the course of the disease was uncontrolled, there were low indicators of external respiratory function, a greater number of exacerbations, a higher need for drugs for basic therapy than in the group of patients with asthma without sensitization to Aspergillus spp. (p

Aspergillus spp.
risk factors

  1. The Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2020. Available at: http://www.ginasthma.org/
  2. Wenzel S. Asthma: defining of the persistent adult phenotypes. Lancet. 2006; 368 (9537): 804–13. DOI: 10.1016/S0140-6736(06)69290-8
  3. Nenasheva N.M. Fenotipy bronhial'noj astmy i vybor terapii. Prakticheskaja pul'monologija. 2014; 2: 2–11 [Nenasheva N.M. Phenotypes of bronchial asthma and the choice of therapy. Practical pulmonology. 2014; 2: 2–11 (in Russ.)].
  4. Agafonova O.V., Gritsenko T.A., Bogdanova Ju.V. i dr. Poliklinicheskaja terapija: Uchebnik. Pod red. D.I. Davydkina, Ju.V. Schukina. 2-e izd., pererab. i dop. M.: GEOTAR-Media, 2020; 840 s. [Agafonova O.V., Gritsenko T.A., Bogdanova Yu.V. et al. Poliklinicheskaya terapiya: Uchebnik. Pod red. D.I. Davydkina, Yu.V. Shchukina. 2-e izd., pererab. i dop. M.: GEOTAR-Media, 2020; 840 s. (in Russ.)]. DOI: 10.33029/9704-5545-6-PLT-2020-1-840
  5. Mari A., Schneider P., Wally V. et al. Sensitization to fungi: epidemiology, comparative skin tests, and IgE reactivity of fungal extracts. Clin Exp Allergy. 2003; 33 (10): 1429–38. DOI: 10.1046/j.1365-2222.2003.01783.x
  6. van de Veerdonk F., Gresnigt M., Romani L. et al. Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol. 2017; 15 (11): 661–74. DOI: 10.1038/nrmicro.2017.90
  7. Rick E., Woolnough K., Pashley C. et al. Allergic Fungal Airway Disease. J Investig Allergol Clin Immunol. 2016; 26 (6): 344–54. DOI: 10.18176/jiaci.0122
  8. Kosmidis C., Denning D. The clinical spectrum of pulmonary aspergillosis. Thorax. 2015; 70 (3): 270–7. DOI: 10.1136/thoraxjnl-2014-206291
  9. Agarwal R., Aggarwal A., Gupta D. et al. Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis. Int J Tuberc Lung Dis. 2009; 13 (8): 936–44.
  10. Kwizera R., Musaazi J., Meya D. et al. Burden of fungal asthma in Africa: A systematic review and meta-analysis. PLoS One. 2019; 14 (5): e0216568. DOI: 10.1371/journal.pone.0216568
  11. Agarwal R. Severe asthma with fungal sensitization. J Fungi. 2016; 2: 13–8.
  12. Denning D., O’Driscoll B., Hogaboam C. et al. The link between fungi and asthma: A summary of the evidence. Eur Respir J. 2006; 27: 615–26. DOI: 10.1183/09031936.06.00074705
  13. Fairs A., Agbetile J., Hargadon B. et al. IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med. 2010; 182 (11): 1362–8. DOI: 10.1164/rccm.201001-0087OC
  14. Agarwal R., Chakrabarti A., Shah A. et al. For the ABPA complicating asthma ISHAM working group 2013. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013; 43 (8): 850–73. DOI: 10.1111/cea.12141
  15. Seliverstov P., Bakaeva S., Shapovalov V. Otsenka riskov sotsial'no znachimyh hronicheskih neinfektsionnyh zabolevanij c ispol'zovaniem telemeditsinskoj sistemy. Vrach. 2020; 10 (31): 68–73 [Seliverstov P., Bakaeva S., Shapovalov V. A telemedicine system in the assesment of risks for socially significant chronic non-communicable diseases. Vrach. 2020; 10 (31): 2–11 (in Russ.)]. DOI: 10.29296/25877305-2020-10-13
  16. Dobritsa V., Leont'eva N., Radchenko V. Profilaktika zabolevanij vnutrennih organov. SPb: Severo-Zapadnyj gosudarstvennyj meditsinskij universitet im. I.I. Mechnikova, 2016; 400 c. [Dobrica V., Leont’eva N., Radchenko V. Profilaktika zabolevanij vnutrennih organov. SPb: North-Western State Medical University named after I.I. Mechnikov, 2016; 400 s. (in Russ.)].
  17. Maurya V., Gugnani H., Sarma U. et al. Sensitization to Aspergillus antigens and occurrence of allergic bronchopulmonary aspergillosis in patients with asthma. Chest. 2005; 127 (4): 1252–9. DOI: 10.1378/chest.127.4.1252
  18. Goh K., Ang Yii A., Lapperre T. et al. Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma. J Asthma Allergy. 2017; 10: 131–40. DOI: 10.2147/JAA.S130459
  19. Menzies D., Holmes L., McCumesky G. et al. Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma. Allergy. 2011; 66: 679–85. DOI: 10.1111/j.1398-9995.2010.02542.x
  20. Moss R.B. Allergic bronchopulmonary aspergillosis and Aspergillus infection in cystic fibrosis. Curr Opin Pulm Med. 2010; 16 (6): 598–603. DOI: 10.1097/MCP.0b013e32833e24a6
  21. Bafadhel M., McKenna S., Agbetile J. et al. Aspergillus fumigatus during stable state and exacerbations of COPD. Eur Respir J. 2014; 43: 64–71. DOI: 10.1183/09031936.00162912