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SENSITIZATION TO ASPERGILLUS SPP. IN PATIENTS WITH ASTHMA

DOI: https://doi.org/10.29296/25877305-2021-05-09
Issue: 
5
Year: 
2021

Associate Professor Ya. Kozlova, Candidate of Medical Sciences; A. Uchevatkina, Candidate of
Medical Sciences; L. Filippova, Candidate of Medical Sciences; O. Aak, Candidate of Chemical Sciences; V.
Kuznetsov; E. Frolova, Candidate of Medical Sciences; Professor N. Vasilyeva, Biol. Dr.; Professor N.
Klimko, MD North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg

Objective: To evaluate the effect of sensitization to Aspergillus spp. the severity and level of control of asthma. Materials and methods: 275 patients with allergic asthma were examined. The levels of total IgE and specific IgE to aeroallergens were determined in the blood serum by the enzyme immunoassay method. Anamnesis, objective examination, and spirometry data were analyzed to assess the reversibility of the obstruction. The Russian-language version of the questionnaire was used: the Asthma Control Test (Asthma Control Test) The data obtained were processed using the Statistica 10 software system. Results: In patients with asthma with sensitization to Aspergillus spp. the course of the disease was uncontrolled, there were low indicators of external respiratory function, a greater number of exacerbations, a higher need for drugs for basic therapy than in the group of patients with asthma without sensitization to Aspergillus spp. (p

Keywords: 
pulmonology
Aspergillus spp.
asthma
risk factors



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