Markers of the hemostatic and fibrinolytic systems in patients with surgical tuberculosis who have experienced COVID-19

DOI: https://doi.org/10.29296/25877305-2021-05-02
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Issue: 
5
Year: 
2021

Professor R. Abdullaev(1), MD; O. Komissarova(1, 2), MD; E. Krasnikova(1), MD; M. Bagirov(1),
MD; Professor A. Ergeshov(1), MD (1)Central Research Institute of Tuberculosis, Moscow (2)N.I. Pirogov
Russian National Research Medical University, Moscow

The paper presents the results of a comparative study of the hemostatic and fibrinolytic systems in 16 patients with pulmonary tuberculosis (PT), who experienced COVID-19, and in 18 patients with PT without COVID-19, who were admitted to the clinic of the Central Research Institute of Tuberculosis for surgical treatment. In the preoperative period, PT patients who had experienced COVID-19 showed a hypercoagulation shift in the plasma component of the hemostatic system, which was accompanied by hyperthrombinemia and compensatory activation of the fibrinolysis system. This was evidenced by a shortened activated partial thromboplastin time (aPTT) and an elevated D-dimer level. Analysis of the results of investigating the markers of the hemostatic and fibrinolytic systems revealed a hypercoagulation shift determined by a shortened aPTT index, an elevated fibrinogen level, a decreased thrombin time and antithrombin III level, and an increased D-dimer level in both groups one day after surgery. At the same time, the most pronounced hypercoagulation shift was observed in patients with PT who had experienced COVID-19.
Keywords: 
infectious diseases
phthisiology
pulmonary tuberculosis
COVID-19
hypercoagulation shift
markers of the hemostatic systems
markers of fibrinolysis

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References: 
  1. Abdullaev R.Ju., Komissarova O.G. Laboratornye projavlenija koronovirusnoj infektsii COVID-19. Vrach. 2020; 31 (5): 3–6 [Abdullaev R., Komissarova O. Laboratory indicators of coronavirus infection COVID-19. Vrach. 2020; 31 (5): 3–6 (in Russ.)]. DOI: 10.29296/25877305-2020-05-01
  2. Abdullaev R.Ju., Kaminskaja G.O., Komissarova O.G. Sdvigi v sisteme gemostaza – komponent sindroma sistemnogo vospalitel'nogo otveta pri tuberkuleze. Vrach. 2012; 2: 24–8 [Abdullayev R., Kaminskaya G., Komissarova O. Shifts in the hemostatic system are a component of systemic inflammatory response syndrome in pulmonary tuberculosis. Vrach. 2012; 2: 24–8 (in Russ.)].
  3. Borodulina E.A., Vasneva Zh.P., Borodulin B.E. i dr. Gematologicheskie pokazateli pri porazhenijah legkih, vyzvannyh infektsiej COVID-19. Klinicheskaja laboratornaja diagnostika. 2020; 65 (11): 676–82 [Borodulina E.A., Vasneva Zh.P., Borodulin B.E. et al. Iron metabolism and indicators reflecting its changes in pulmonary tuberculosis (review of literature). Clinical laboratory diagnostics. 2020; 65 (11): 67682 (in Russ.)]. DOI: 10.18821/0869-2084-2020-65-3-149-154
  4. Vremennye metodicheskie rekomendatsii MZ RF «Profilaktika, diagnostika i lechenie novoj koronavirusnoj infektsii. Versija 10 ot 08.02.2021; 260 s. [Vremennye metodicheskie rekomendatsii MZ RF «Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii. Versiya 10 ot 08.02.2021; 260 s. (in Russ.)].
  5. Mamaev A.N., Kudlaj D.A. Statisticheskie metody v meditsine. M.: Prakticheskaja meditsina, 2021; 136 s. [Mamaev A.N., Kudlay D.A. Statisticheskie metody v meditsine. M.: Prakticheskaya meditsina, 2021; 136 s. (in Russ.)].
  6. Lippi G., Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020; 58 (7): 1131–4. DOI: 10.1515/cclm-2020-0198
  7. Mukund K., Mathee K., Subramaniam S. Plasmin cascade mediates thrombolytic events in SARS-CoV-2 infection via complement and platelet-activating systems. bioRxiv. 2020. DOI: 10.1101/2020.05.28.120162
  8. Robson S.C., White N.W., Aronson I. et al. Acute-phase response and the hypercoagulable state in pulmonary tuberculosis. Br J Haematol. 1996; 93 (4): 943–9. DOI: 10.1046/j.1365-2141.1996.d01-1722.x
  9. Stochino C., Villa S., Zucchi P. et al. Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital. Eur Respir J. 2020; 56 (1): 2001708. DOI: 10.1183/13993003.01708-2020
  10. Tang N., Li D., Wang X. et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020; 18 (4): 844–7. DOI: 10.1111/jth.14768