The importance of pregravid preparation for improving perinatal outcomes in patients with a history of placenta-related pregnancy complications
DOI: https://doi.org/10.29296/25877305-2021-01-07
Issue:
1
Year:
2021
Studies of the efficacy of low-molecular-weight heparins (LMWH) used in patients with a history of
placenta-related pregnancy complications (PRPC) and the impact of this therapy on perinatal and long-term
child development outcomes are presented by small cohort studies that are rather heterogeneous and do not
answer the question of whether LMWH therapy is necessary at the pregravid stage. Objective. To evaluate the
impact of pregravid preparation using LMWH in women with a history of PRPC on pregnancy course and outcomes
and perinatal and long-term child development outcomes. Subjects and methods. The investigation enrolled 89
patients. According to the time of LMWH therapy initiation, the patients were divided into 3 groups: 1) 29
patients who initiated LMWH therapy at the pregravid stage; 2) 30 patients who started this therapy in the
first trimester of pregnancy; 3) 30 patients who did this when they developed complications. The effect of
the start of therapy on the incidence of PRPC, the course of the early neonatal period, and long-term child
development outcomes was evaluated. Results. Combination therapy using LMWH in patients with a history of
PRPC leads to a decrease in the frequency of these complications. The efficiency of the therapy depends on
the time of drug administration: pregravid preparation is most effective and makes it possible to reduce the
frequency and severity of PRPC, perinatal morbidity and mortality rates, and infant morbidity during the
first year of life. The therapy that is initiated when the complications manifest is ineffective.
Conclusion. Pregravid preparation using LMWH improves perinatal outcomes in patients with a history of
PRPC.
Keywords:
obstetrics and gynecology
placenta
low-molecular-weight heparins
preeclampsia
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