Use of oral subtilisins in the treatment of acute ascending varicothrombophlebitis

DOI: https://doi.org/10.29296/25877305-2020-12-14
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Issue: 
12
Year: 
2020

Professor E. Krivoshchekov(1), MD; E. Elshin(2); Professor V. Romanov(3), MD; A. Poseryaev(4);
G. Alyapyshev(4) (1)Samara State Medical University, Ministry of Health of Russia (2)Samara City Hospital
Eight (3)Territorial Compulsory Health Insurance Fund in the Samara Region, Samara (4)Ulyanovsk Regional
Clinical Hospital, Ulyanovsk

The paper describes the experience with the oral fibrinolytic thrombovazim in the medical treatment of acute ascending varicothrombophlebitis of the lower extremities when using a direct oral anticoagulant, diosmin preparations, and elastic leg compression. The investigation enrolled 104 patients with a confirmed diagnosis of acute ascending varicothrombophlebitis. The patients were divided into 2 groups similar with respect to sex, age, and degree and level of saphenous vein thrombosis: 1) 50 patients received only basic therapy according to clinical practice guidelines (a comparison group); 2) 54 patients had basic therapy in combination with a fibrinolytic drug (thrombovazim), 800 IU, twice daily for 20 days (a study group). The paper presents comparative results after 3 and 6 months of the start of treatment in both groups, analyzes the time course of changes in venous bed recanalization and that in reducing the clinical manifestations of the disease, and evaluates the safety of this treatment method.
Keywords: 
therapy
saphenous vein thrombosis of the lower limbs
varicothrombophlebitis
medical treatment
fibrinolytic
direct oral anticoagulant

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