On hepatotoxicity of drugs used in dermatology
DOI: https://doi.org/10.29296/25877305-2020-09-09
Issue:
9
Year:
2020
Cutaneous reactions to various drugs are quite common, whereas hepatic reactions occur less
frequently and may go unnoticed. Many drugs can damage the liver injuries; antiepileptic drugs, allopurinol,
sulfonamides, antibiotics, and nevirapine are among the top 5 most common causes of drug-induced liver
injuries. But let us not forget that the list of such drugs is much longer and it includes drugs that are
widely used in different fields of medicine. Thus, systemic retinoids used long-term cause changes in blood
biochemical parameters; these changes are often transient and do not require treatment discontinuation.
Cyclosporine used to treat autoimmune diseases can cause increased creatinine levels and acute
cholecystitis. Long-term use of methotrexate, even at low doses, or administration of systemic
glucocorticosteroids can induce steatosis and other liver injuries. When prescribing medications that can
cause disturbances in the hepatobiliary system, it is necessary to take into account a patient’s medical
history and concomitant diseases, to regularly monitor blood biochemical parameters, and to incorporate
hepatoprotective agents in therapy. The physician should also take into consideration possible drug
interactions with the medications that the patient is already taking; this is particularly important in
terms of the widespread use of polypharmacy. In our practice, we often give preference to a medication
containing glycyrrhizic acid and essential phospholipids, since this combination has not only a
hepatoprotective effect, but also has an anti-inflammatory effect. The inclusion of hepatoprotective agents
in therapy on the first days allows avoidance of unwanted hepatotoxic effects that may be asymptomatic or
irreversible in some cases.
Keywords:
hepatology
dermatology
hepatotoxicity
hepatoprotectors
glycyrrhizic acid
essential phospholipids
liver injuries
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