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Professor О. Osipova(1), MD; Professor O. Drapkina(2), MD, Corresponding Member of the Russian Academy of Sciences; R. Shepel(2); Е. Gosteva(3), Candidate of Medical Sciences; O. Godlevskaya(4), Candidate of Medical Sciences; О. Belousova(1), Candidate of Medical Sciences; (1)Belgorod State National Research University (2)National Medical Research Centre for Therapy and Preventive Medicine, Moscow (3)N.N. Burdenko Voronezh State Medical University (4)Kharkov Medical Academy of Postgraduate Education, Ukraine

In pathological conditions, the activity of matrix metalloproteinases (MMP) increases, which leads to an imbalance between the synthesis and degradation of the extracellular matrix, which provokes the development of fibrosis in the myocardium, which contributes to the occurrence of heart failure. The aim of the study. To evaluate the features of collagen metabolism in elderly patients with chronic heart failure, an intermediate ejection fraction of heart failure with mid-range ejection fraction (HFmrEF) against the background of metabolic syndrome (MS). Material and methods. The study included 180 patients with HFmrEF (40–49%), functional class II according to NYHA (NYHA class II) of ischemic origin. We assessed the age of patients, the presence of MS, and levels of tissue inhibitor metalloproteinases tissue inhibitor metalloproteinas (TIMP-1), MMP-1, MMP-9. Results. Depending on the presence of MS in patients with HFmrEF, there was a significant (p

myocardial fibrosis
heart failure with mid-range ejection fraction
metabolic syndrome

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