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AGING AND LIVER PATHOLOGY: MOLECULAR AND CELL ASPECTS

DOI: https://doi.org/10.29296/25877305-2020-06-03
Issue: 
6
Year: 
2020

I. Mesheriakova(1); A. Ilina(1, 2); N. Linkova(1, 3), Doctor of Biological Sciences; M. Koroleva(3), Candidate of Medical Sciences; Professor V. Khavinson(1, 4), Corresponding Member of RAS (1)Saint Petersburg Bioregulation and Gerontology Institute (2)Institute of biomedical systems and biotechnologies, Peter the Great Saint Petersburg Polytechnic University (3)Academy of Postgraduate Education under Federal Scientific and Clinical Center for Specialized types Medical Assistance and Medical Technologies of the FMBA, Moscow (4)Pavlov Institute of Physiology Russian Academy of Sciences, Saint Petersburg

Age-associated liver disease is one of the leading causes of reduced ability to work and the development of polymorbidity syndrome. The incidence of non-alcoholic fatty liver disease (NAFLD) and hepatitis increases with age and is about 20% in the working-age population of developed countries. The purpose of the review is to analyze the molecular mechanisms of development of age-related liver involution in normal and pathological conditions and to search for promising methods of differential diagnosis. The review describes the role of cell aging proteins and apoptosis (p16ink4a, p21, p53) and factors that regulate the hepatocyte cell cycle (Cdk1, Skp2, Ccne2, pRb, survivin, Ssu72) in the development of liver pathology. Blood plasma proteins (CYP450, GLDH, SDH, K18, GST), sulfitoxidase, cytokeratin 18, etc. are considered as new markers of liver damage. Serum triglycerides, miRNA-122, miRNA-10b, miRNA-33 are specific biomarkers of NAFLD also methylation status MT-ND6. A possible way of steatohepatitis diagnostic to influence the signaling of FXR, FGF19, PPARα, YAP / TAZ. It is assumed that the targets for the action of new generation hepatoprotectors in case of age-related liver pathology may be cytokines (TGF, TNF, IL-6) and vascular endothelial growth factor (VEGF).

Keywords: 
aging
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
hepatoprotectors
molecular markers



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