Molecular mechanisms for regulation of the functional activity of blood cells: improvement of targeted anti-inflammatory therapy

DOI: https://doi.org/10.29296/25877305-2019-11-03
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Issue: 
11
Year: 
2019

Professor V. Barinov(1), MD; Kh. Grigoryan(2), Candidate of Medical Sciences; T. Faber(1); V. Sokhina(1); A. Perenesenko(1) 1-M.Gorky Donetsk National Medical University, Ukraine 2-Donetsk Regional Clinical Territorial Medical Association, Ukraine

The frequency of complications associated with the development of acute inflammation and recurrent chronic diseases necessitates the improvement of conventional methods for prevention and treatment. The promising area in the development of targeted therapy is the management of the mechanisms for leukocyte activation and recruitment from circulating blood into the focus of inflammation, which would bring us closer to the possibility of controlled development of the inflammatory response. The review provides much evidence for modulation of the functional activity of leukocytes and their transendothelial migration during stimulation of α- and β-adrenergic receptors. It discusses the practical significance of the leukocyte expression of purinergic P2 receptors. The review also presents the possible mechanisms for activation of monocytes and macrophages during stimulation of P2X receptors (P2X1, P2X4, P2X5, and P2X7), which makes it possible to predict their anti-inflammatory potential, as well as to control the development of inflammation in future. It analyzes the regulatory capabilities of the main subtypes of P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14), which are involved in the regulation of phagocytosis, the secretion of cytokines, and the adhesion and migration of leukocytes. The authors consider the role of platelets that express purine receptors (P2Y1, P2Y12, P2Y14, and P2X1) in the recruitment and chemotaxis of leukocytes in inflammation and provide evidence that there are prospects for the selective action on blood cell adrenergic and purinergic receptors as a therapeutic target in a systemic inflammatory response.
Keywords: 
therapy
inflammation
leukocytes
platelets
α- and β-adrenergic receptors
purine P2 receptors

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