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Telomere length as a marker of life expectancy after resection surgery

DOI: https://doi.org/10.29296/25877305-2019-10-18
Issue: 
10
Year: 
2019

G. Eleuov(1, 2), Candidate of Medical Sciences; A. Akilzhanova(2); Professor O. Ospanov(1, 2), MD; D. Vychuzhanin(3), Candidate of Medical Sciences; Professor T. Mukantaev(1), MD; E. Gelmutdinova(3) 1-Astana Medical University, Nur-Sultan, Kazakhstan 2-«University Medical Center» Corporate Fund, Nur-Sultan, Kazakhstan 3-I.M. Sechenov First Moscow State Medical University

The paper presents the results of estimating the telomere length as a marker of biological aging after gastric bypass surgery in patients with metabolic syndrome. After weight loss, the telomere length is noted to have increased in all the compared surgical groups without statistically significant differences.

Keywords: 
obesity
metabolic syndrome
gastric bypass surgery
telomere
band-divided gastric bypass surgery



References: 
  1. Fursov R., Ospanov O., Fursov A. Prevalence of obesity in Kazakhstan // AMJ. – 2017; 10 (11): 916–20. DOI: 10.21767/AMJ.2017.3169.
  2. Fursov R., Ospanov O., Fursov A. Obesity as an actual problem: spatial research in Kazakhstan (2011–2016) // Indian J. Public Health Res. Dev. – 2018; 9: 1–7. DOI: 10.5958/0976-5506.2018.00603.4.
  3. Ospanov O., Eleuov G., Kadyrova I. et al. The life expectancy of patients with metabolic syndrome after weight loss: study protocol for a randomized clinical trial (LIFEXPE-RT) // Trials. – 2019; 20 (1): 202. DOI: 10.1186/s13063-019-3304-9.
  4. Ospanov O. Laparoscopic band-separated one anastomosis gastric bypass // Obes. Surg. – 2016; 26: 2268–9. DOI: 10.1007/s11695-016-2281-2.
  5. Laimer M., Melmer A., Lamina C. et al. Telomere length increase after weight loss induced by bariatric surgery: results from a 10 years prospective study // Int. J. Obes. (Lond) – 2015; 40: 773–8. http://dx.doi.org/10.1038/ijo.2015.238.
  6. Njajou O., Cawthon R., Blackburn E. et al. Shorter telomeres are associated with obesity and weight gain in the elderly // Int. J. Obes. (Lond). – 2012; 36 (9): 1176–9. DOI: 10.1038/ijo.2011.196.
  7. Shalev I., Entringer S., Wadhwa P. et al. Stress and telomere biology: a lifespan perspective // Psychoneuroendocrinology. – 2013; 38 (9): 1835–42. http://dx.doi.org/10.1016/j.psyneuen.2013.03.010.
  8. Lee M., Martin H., Firpo M. et al. Inverse association between adiposity and telomere length: the Fels longitudinal study // Am. J. Hum. Biol. – 2011; 23: 100–6. http://dx.doi.org/10.1002/ajhb.21109.
  9. Cawthon R. et al. Association between telomere length in blood and mortality in people aged 60 years or older // Lancet. – 2003; 361 (9355): 393–5.
  10. Carulli L. et al. Telomere length elongation after weight loss intervention in obese adults // Mol. Genet. Metab. – 2016; 118 (2): 138–42. DOI: 10.1016/j.ymgme.2016.04.003.
  11. Muezzinler A., Zaineddin A., Brenner H. Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis // Obes. Rev. – 2014; 15 (3): 192–201. http://dx.doi.org/10.1111/obr.12126.