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Combination pathogenetic therapy for psoriasis: relief of inflammation and correction of metabolic disorders


Professor A. Piruzyan(2), MD; E. Denisova(1, 2), Candidate of Medical Sciences; E. Dvoryankova(2), MD; M. Denieva(3), Candidate of Medical Sciences; V. Sobolev(2); Professor I. Korsunskaya(1, 2), MD 1-Moscow Research and Practical Center for Dermatovenereology and Cosmetology 2-Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow 3-Republican Dermatovenereology Dispensary, Groznyi

Psoriasis is an autoimmune inflammatory disease that is characterized by a predominant skin lesion and has a complex pathogenesis. The current scientific concept of the pathogenesis of this dermatosis gives pride of place in its development to immune-mediated inflammation, the main mechanism of which is immune cell dysfunction. In addition, systemic and local dyslipidemia can cause inflammation. Immunoinflammatory responses and lipid profile disorders are currently considered as promising therapeutic targets for psoriasis. The authors’ own observations show that the inclusion of drugs that can affect both inflammation and lipid profile (glycyrrhizic acid and essential phospholipids) in the combination therapy of psoriasis makes it possible not only to normalize the blood levels of total cholesterol, triglycerides and other lipids, but also to more quickly get significant regression results in skin rashes.

essential phospholipids
glycyrrhizic acid

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