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Professor S. Mravyan, MD; S. Novikova, MD; I. Shuginin, MD; E. Upryamova; N. Biryukova; I. Bocharova, MD Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow

The paper describes a case of pregnancy in a patient with osteogenesis imperfecta (OI). Both Russian and foreign medicine recognizes this disorder as a contraindication to pregnancy due to the high risk of maternal and fetal complications. The paper gives data on current treatments for OI with drugs that inhibit bone resorption. It is noted that their use in women of childbearing age should be considered as an element of pregravid preparation; even in case of their discontinuation during pregnancy, they contribute to the improvement a perinatal outcome and to the intrauterine consolidation of resulting fractures. This conclusion is based on a previous clinical observation. The safety of using bisphosphonates, teriparatide, denosumab, and strontium ranelate in patients during pregnancy and, possibly, lactation is to be investigated.

osteogenesis imperfecta

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