THE ANTIHOMOTOXIC MEDICATION TRAUMEEL S: AN INTEGRATIVE REVIEW OF THE EVIDENCE OF ITS EFFICACY

Download full text PDF
Issue: 
3
Year: 
2017

R. van Haselen International Institute for Integrated Medicine, Kingston, United Kingdom

The paper provides an overview of the evidence on the efficacy of Traumeel S that may be used as an agent of basic or adjuvant treatment for inflammatory diseases of various organs and tissues, in particular locomotor apparatus diseases (tenosynovitis, bursitis, styloiditis, periarthritis, etc.), and posttraumatic conditions (postoperative soft tissue swelling, muscle strain and ligament sprain).
Keywords: 
soft tissue inflammatory diseases
locomotor apparatus diseases
posttraumatic conditions
treatment
Traumeel S

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. CEBM Web site. http://www.cebm.net/wp-content/uploads/2014/06/CEBM-Levels-of-Evidence-2.1.pdf. Accessed February 22, 2017.
  2. van Haselen R. Medical study formats: an overview // J. Biomed. Ther. – 2010; 4 (2): 26–7.
  3. Schneider C. Traumeel: an emerging option to nonsteroidal anti-inflammatory drugs in the management of acute musculoskeletal injuries // Int. J. Gen. Med. – 2011; 4: 225–34. DOI:10.2147/ijgm.s16709.
  4. Müller-Löbnitz C., Göthel D. Review of the clinical efficacy of the multicomponent combination medication Traumeel and its components // Altern. Ther. Health Med. – 2011; 17 (suppl. 2): 18–31.
  5. Speed C., Wolfarth B. Challenges of pain masking in the management of soft tissue disorders: optimizing patient outcomes with a multi-targeted approach // Curr. Med. Res. Opin. – 2014; 30 (5): 953–9. DOI:10.1185/03007995.2014.913412.
  6. Zell J., Connert W., Mau J. et al. Treatment of acute sprains of the ankle: a controlled double-blind trial to test the effectiveness of a homeopathic ointment // Biol. Ther. – 1989; 7 (1): 1–6.
  7. Zell J., Connert W., Mau J. et al. Behandlung von Sprunggelenksdistorsionen: Doppelblindstudie zum Wirksamkeitsnachweis eines homöopathischen Salbenpräparats // Fortschr. Med. – 1988; 106 (5): 96–100.
  8. Thiel W., Borho B. The treatment of recent traumatic blood effusions of the knee joint // Biol. Ther. – 1994; 12 (4): 242–8.
  9. Thiel W., Borho B. Posttraumatische Kniegelenksergüsse und intraartikuläre Traumeel-N-Injektion // Orthopädische Prax. – 1991; 27 (11): 721–5.
  10. Böhmer D., Ambrus P. Treatment of sports injuries with Traumeel ointment: a controlled double-blind study // Biol. Ther. – 1992; 10 (4): 290–300.
  11. Arora S., Harris T., Scherer C. Clinical safety of a homeopathic preparation // Biomed. Ther. – 2000; 18 (2): 222–5.
  12. González de Vega C., Speed C., Wolfarth B. et al. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non-inferiority trial // Int. J. Clin. Pract. – 2013; 67 (10): 979–89. DOI:10.1111/ijcp.12219.
  13. Lozada C., del Rio E., Reitberg D. et al. Risk-benefit of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections in patients with moderate-to-severe pain associated with OA of the knee (OAK) (THU0441) // Ann. Rheum. Dis. – 2015; 74 (Suppl. 2): 4268. DOI:10.1136/annrheumdis-2015-eular.426810.
  14. Lozada C., del Rio E., Reitberg D. et al. A multi-center double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections versus IA placebo in patients with moderate-to-severe pain associated with OA of the knee // Arthritis Rheum. – 2014; 66 (Suppl.): 1266.
  15. Zenner S., Metelmann H. Therapy experiences with a homeopathic ointment: Results of drug surveillance conducted on 3,422 patients // Biol. Ther. – 1994; 12 (3): 204–11.
  16. Zenner S., Metelmann H. Application possibilities of Traumeel S injection solution: Results of a multicentric drug monitoring trial conducted on 3,241 patients // Biol. Ther. – 1992; 10 (4): 301–10.
  17. Zenner S., Weiser M. Oral treatment of traumatic, inflammatory, and degenerative conditions with a homeopathic remedy // Biomed. Ther. – 1997; 15 (1): 22–6.
  18. Weiser M., Zenner S. Orale Therapie traumatischer, entzündlicher und degenerativer Affektionen mit einem Homöopathikum // Biol. Medizin. – 1996; 25 (5): 211–6.
  19. Ludwig J., Weiser M. Treating pediatric trauma with a homeopathic ointment // J. Biomed. Ther. – 2001; 2: 8–11.
  20. Birnesser H., Oberbaum M., Klein P. et al. The homeopathic preparation Traumeel S compared with NSAIDs for symptomatic treatment of epicondylitis // J. Musculoskelet. Res. – 2004; 8 (2–3): 119–28. DOI:10.1142/S0218957704001284.
  21. Schneider C., Schneider B., Hanisch J. et al. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study // Complement Ther. Med. – 2008; 16 (1): 22–7. DOI:10.1016/j.ctim.2007.04.004.
  22. Schneider C., Klein P., Stolt P. et al. A homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathy // Explore (NY). – 2005; 1 (6): 446–52. DOI:10.1016/j.explore.2005.08.010.
  23. Conforti A., Bertani S., Lussignoli S. et al. Wirkungen Antihomotoxischer Präparate auf akute und chronische Entzündungen // Biol. Medizin. – 1998; 27 (2): 63–6.
  24. Conforti A., Bertani S., Metelmann H. et al. Experimental studies on the anti-inflammatory activity of a homeopathic preparation // Biomed. Ther. – 1997; 15 (1): 28–31.
  25. Enbergs H. The effect of selected potentiated suis organ preparations and Traumeel on phagocyte and lymphocyte activity // Biomed. Ther. – 1998; 16 (2): 178–85.
  26. Lussignoli S., Bertani S., Metelmann H. et al. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats // Complement Ther. Med. – 1999; 7 (4): 225–30.
  27. Heine H., Andrä F. On the anti-inflammatory mechanism of action of an antihomotoxic compound remedy [in German] // Ärztezeitschrift für Naturheilverfahren. – 2002; 43 (2): 96–104.
  28. Porozov S., Cahalon L., Weiser M. et al. Inhibition of IL-1β and TNF-α secretion from resting and activated human immunocytes by the homeopathic medication Traumeel® S // Clin. Dev. Immunol. – 2004; 11 (2): 143–9. DOI:10.1080/10446670410001722203.
  29. Seilheimer B., Wierzchacz C., Gebhardt R. Influence of Traumeel on cultured chondrocytes and recombinant human matrix metalloproteinases: implications for chronic joint diseases // Eur. J. Integr. Med. – 2009; 1 (4): 252–3.
  30. St. Laurent G., Tackett M., McCaffrey T. et al. Deep sequencing transcriptome analysis of Traumeel therapeutic action in wound healing (THU0016) // Ann. Rheum. Dis. – 2013; 72 (Suppl. 3). doi:10.1136/annrheumdis-2013-eular.544.
  31. Wolfarth B., González de Vega C., Kapranov P. et al. Inflammation in soft tissue disorders: the evidence and potential role for a natural multi-target medication // Curr. Med. Res. Opin. – 2013; 29 (suppl. 2): 1–2. DOI:10.1185/03007995.2013.779874.
  32. Speed C., González de Vega C. Treatment of musculo-skeletal inflammatory disorders using a clinically proven medication with a novel mechanism of action // Ann. Rheum. Dis. – 2011; 70 (Suppl. 3): 685.
  33. Cesnulevicius K. The bioregulatory approach to work-related muskuloskeletal disorders: using the multicomponent ultra low-dose medication Traumeel to target the multiple pathophysiological processes of the disease // Altern. Ther. Health Med. – 2011; 17 (Suppl. 2): 8–17.
  34. Orchard J., Best T., Mueller-Wohlfahrt H. et al. The early management of muscle strains in the elite athlete: best practice in a world with a limited evidence basis // Br. J. Sports Med. – 2008; 42 (3): 158–9. DOI:10.1136/bjsm.2008.046722.
  35. González de Vega C., Gonzáles J. A randomized, controlled, multicenter study on the effectiveness of Traumeel (ointment and gel) in terms of pain reduction and function improvement compared with diclofenac gel in acute ankle sprain // Ann. Rheum. Dis. – 2012; 71 (Suppl. 3): SAT0423.