Chaga birch mushroom: anti-inflammatory, antioxidant, immunomodulatory, antiviral effects, the possibility of using the Russian drug BioChaga in patients with novel coronavirus infection (COVID-19)
DOI: https://doi.org/10.29296/25877305-2022-08-18
Issue:
8
Year:
2022
In the work performed: analysis of 28 publications from the People’s Republic of China, the Russian Federation, the United States, Great Britain, the Republic of Poland, Hungary, Serbia, the Republic of Korea, Portugal, the Netherlands, Saudi Arabia, Egypt, the Republic of South Africa. Reflected: anti-inflammatory, antioxidant, immunomodulatory, antiviral effect of birch chaga mushroom. Showed: a wide range of antiviral action of birch chaga mushroom. Presented: research on the effectiveness of the use of chaga in coronovirus infection. Studied: the possibility of using the Russian drug BioChaga in patients with novel coronavirus infection (COVID-19).
Keywords:
novel coronavirus infection
BioChaga
anti-inflammatory
SARS-CoV-2
immunomodulatory
antiviral
action
prevention
Baikal Legend
SibPribor LLC
Inonotus obliquus
medicinal mushrooms.
References:
- Kou R.W., Han R., Gao Y.Q. et al. Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus. Phytochemistry. 2021; 184: 112647. DOI: 10.1016/j.phytochem.2020.112647
- Szychowski K.A., Skóra B., Pomianek T. et al. Inonotus obliquus – from folk medicine to clinical use. J Tradit Complement Med. 2021; 11 (4): 293–302. DOI: 10.1016/j.jtcme.2020.08.003
- Teplyakova T.V., Ilyicheva T.N., Kosogova T.A. et al. Medicinal Mushrooms against Influenza Viruses. Int J Med Mushrooms. 2021; 23 (2): 1–11. doi: 10.1615/IntJMedMushrooms.2020037460
- Nosik D.N., Nosik N.N., Teplyakova T.V. et al. Antiviral activity of extracts of basidiomycetes and humic compounds substances against Human Immunodeficiency Virus (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus 1) and Herpes Simplex Virus (Herpesviridae: Simplexvirus: Human alphaherpesvirus 1). Problems of Virology. 2020; 65 (5): 276–83 (in Russ.). DOI: 10.36233/0507-4088-2020-65-5-4
- Teplyakova Т., Pyankov O., Safatov A.et al. Water Extract of the Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Inhibits SARS-CoV-2 Replication in Vero E6 and Vero Cell Culture Experiments. Int J Med Mushrooms. 2022; 24 (2): 23–30. DOI: 10.1615/IntJMedMushrooms.2021042012
- Shahzad F., Anderson D., Najafzadeh M. The Antiviral, Anti-Inflammatory Effects of Natural Medicinal Herbs and Mushrooms and SARS-CoV-2 Infection. Nutrients. 2020; 12 (9): 2573. DOI: 10.3390/nu12092573
- Cui Y., Kim D.S., Park K.C. Antioxidant effect of Inonotus obliquus. J Ethnopharmacol. 2005; 96 (1–2): 79–85. DOI: 10.1016/j.jep.2004.08.037
- Usoltseva O.N., Olennikov D.N., Potupchik T.W. Evaluation of the quality and biological activity of the extract of birch mushroom chaga «BioChaga». Pharmacy. 2022; 71 (2): 33–40 (in Russ.). DOI: 10.29296/25419218-2022-02-06
- Lu Y., Jia Y., Xue Z. et al. Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers (Basel). 2021; 13 (9): 1441. DOI: 10.3390/polym13091441
- Glamočlija J., Ćirič A., Nikolič M. et al. Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal «mushroom». J Ethnopharmacol. 2015; 162: 323–32. DOI: 10.1016/j.jep.2014.12.069
- Zmitrovich I.V., Denisova N.P., Balandaykin M.E. et al. Chaga and its bioactive complexes: history and prospects. Pharmacy formulas. 2020; 2 (2): 84–93 (in Russ.). DOI: 10.17816/phf34803
- Duru K.C., Kovaleva E.G., Danilova I.G. et al. The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies. Phytother Res. 2019; 33 (8): 1966–80. DOI: 10.1002/ptr.6384
- Teplyakova T.V., Kosogova T.A., Andreeva I.A. i dr. Antivirusnaya, antibakterial’naya i antigribkovaya aktivnost’ komponentov trutovika skoshennogo, chagi Inonotus obliquus (Fr.) Pil. Uspekhi meditsinskoi mikologii. 2019; 20: 535–40 (in Russ.).
- Usoltseva O.N. Prevention of accelerated aging and «diseases of civilization» with the help of natural geroprotectors BioChaga and BioDihydroquercetin. Meditsinskaya sestra. 2022; 3: 34–40 (in Russ.). DOI: 10.29296/25879979-2022-03-07
- Garádi Z., Dékány M., Móricz Á.M. et al. Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici. Molecules. 2021; 26 (18): 5453. DOI: 10.3390/molecules26185453
- Szychowski K.A., Skóra B., Pomianek T. et al. Inonotus obliquus – from folk medicine to clinical use. J Tradit Complement Med. 2020; 11 (4): 293–302. DOI: 10.1016/j.jtcme.2020.08.003
- Park Y.M., Won J.H., Kim Y.H. et al. In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus. J Ethnopharmacol. 2005; 101 (1–3): 120–8. DOI: 10.1016/j.jep.2005.04.003
- Fan L., Ding S., Ai L. et al. Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus. Carbohydr Polym. 2012; 90 (2): 870–4. DOI: 10.1016/j.carbpol.2012.06.013
- Niu H., Song D., Mu H. et al. Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus. Int J Biol Macromol. 2016; 86: 587–93. DOI: 10.1016/j.ijbiomac.2016.01.111
- Liu Z., Yu D., Li L. et al. Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus. Molecules. 2019; 24 (3): 403. DOI: 10.3390/molecules24030403
- Won D.P., Lee J.S., Kwon D.S. et al. Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus. Mol Cells. 2011; 31 (2): 165–73. DOI: 10.1007/s10059-011-0022-x
- Guo Y., Chen X., Gong P. Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus. Int J Biol Macromol. 2021; 183: 1753–73. DOI: 10.1016/j.ijbiomac.2021.05.139
- Shahzad F., Anderson D., Najafzadeh M. The Antiviral, Anti-Inflammatory Effects of Natural Medicinal Herbs and Mushrooms and SARS-CoV-2 Infection. Nutrients. 2020; 12 (9): 2573. DOI: 10.3390/nu12092573
- Huang C., Wang Y., Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497–506. DOI: 10.1016/S0140-6736(20)30183-5
- Zhang J., Zhou L., Yang Y. et al. Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics. Lancet Respir Med. 2020; 8 (3): e11–12. DOI: 10.1016/S2213-2600(20)30071-0
- Xu Z., Li S., Tian S. et al. Full spectrum of COVID-19 severity still being depicted. Lancet. 2020; 395 (10228): 947–8. DOI: 10.1016/S0140-6736(20)30308-1
- Elshemey W.M., Elfiky A.A., Ibrahim I.M. et al. Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective. Comput Biol Med. 2022; 145: 105478. DOI: 10.1016/j.compbiomed.2022.105478
- Usoltseva O.N. Effective natural remedies BioChaga and BioDihydroquercetin to safely help the body at all stages of viral infection COVID-19. Meditsinskaya sestra. 2022; 2: 20–2 (in Russ.). DOI: 10.29296/25879979-2022-02-05