Modern principles in the treatment of brain contusions

DOI: https://doi.org/10.29296/25877305-2020-12-04
Download full text PDF
Issue: 
12
Year: 
2020

A. Yarikov(1)–3, Candidate of Medical Sciences; P. Smirnov(2), Candidate of Medical Sciences;
Professor A. Fraerman(2), MD; V. Leonov(2); V. Khakhin(3) (1)City Clinical Hospital Thirteenth, Nizhny
Novgorod (2)City Clinical Hospital Thirty-Nine, Nizhny Novgorod (3)Volga District Medical Center, Federal
Biomedical Agency, Nizhny Novgorod

Craniocerebral traumas (CCT) account for 40% in the pattern of traumatic injuries. Brain damage is the leading cause of death and disability in the populations under 40 years of age. According to the clinical classification of brain contusions (BC) in Russia, which evaluates the clinical course of CCT and neurological status, they are divided into mild, moderate and severe types. The authors also identify an anatomical classification, such as foci of local posttraumatic ischemia or those of type I contusion, foci of contusion or those of type II contusion, intracerebral hematomas or foci of type III contusion. In the clinical course of BC, one type of contusion turns into another, i.e. its development is a dynamic process. An increase in the BC focus over time is called its progression, while 35-50% of hemorrhagic foci are prone to develop. The paper describes predictors for the progression of contusion foci and also considers in detail the treatment of BC, namely medical and surgical treatments. Neuroprotection occupies a special place in the treatment of BC.

Keywords: 
traumatology
neurology
brain contusion
neuroprotection
decompressive craniotomy
secondary injury
evolution of a brain contusion focus



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Danilov V.I., Turaeva R.G., Vahitov Sh.M. i dr. O tselesoobraznosti usovershenstvovanija statisticheskogo izuchenija cherepno-mozgovogo travmatizma. Kazanskij meditsinskij zhurnal. 2004; 85 (1): 67–9 [Danilov V.I., Turaeva R.G., Vahitov Sh.M. et al. On the feasibility of improving the statistical study of craniocerebral injury. Kazanskii meditsinskii zhurnal. 2004; 85 (1): 67–9 (in Russ.)].
  2. Tihomirov S.E. Plastika kostej svoda cherepa materialom «REPEREN». Rossijskij nejrohirurgicheskij zhurnal im. prof. A.L. Polenova. 2010; 3 (2): 52–6 [Tihomirov S.E. Rlasty of defects of calvarium with «REPEREN» material (experimental and clinical results). Rossiiskii neirokhirurgicheskii zhurnal im. prof. A.L. Polenova. 2010; 3 (2): 52–6 (in Russ.)].
  3. Shehovtsova K.V., Shehovtsov V.I., Kondakov E.N. Epidemiologija cherepno-mozgovoj travmy i organizatsija meditsinskoj pomoschi postradavshim v Stavropol'skom krae. Nejrohirurgija. 2006; 3: 59–63 [Shekhovtsova K.V., Shekhovtsov V.l., Kondakov E.N. The epidemiology of head injury and the organization of medical care for the hurt individuals living in Stavropol region. Russian journal of neurosurgery. 2006; 3: 59–63 (in Russ.)].
  4. Talypov A.E., Petrikov S.S., Puras Ju.V. i dr. Lechenie ushibov golovnogo mozga. Meditsinskij sovet. 2013; 4: 82–91 [Talypov A.E., Petrikov S.S., Puras Yu.V. et al. Treatment of brain injury. Meditsinskiy sovet = Medical Council. 2013; 4: 82–91 (in Russ.)]. https://doi.org/10.21518/2079-701X-2013-4-82-91
  5. Puras Ju.V., Talypov A.E. Faktory riska razvitija neblagoprijatnogo ishoda v hirurgicheskom lechenii ostroj cherepno-mozgovoj travmy. Nejrohirurgija. 2013; 2: 8–16 [Puras J.V., Talypov A.E. Risk factors for unfavorable outcome in surgical treatment of acute head injury. Russian journal of neurosurgery. 2013; 2: 8–16 (in Russ.)]. https://doi.org/10.17650/1683-3295-2013-0-2-8-16
  6. Puras Ju.V., Talypov A.E., Petrikov C.S. i dr. Faktory vtorichnogo ishemicheskogo povrezhdenija golovnogo mozga pri cherepno-mozgovoj travme chast' 1. vnutricherepnye i vnecherepnye faktory vtorichnogo povrezhdenija mozga. Zhurnal im. N.V. Sklifosovskogo Neotlozhnaja meditsinskaja pomosch'. 2012; 1: 56–65 [Puras U.V., Talypov A.E., Petrikov S.S. et al. Factors of secondary ischemic cerebral damage at craniocerebral trauma part 1. intracranial and extracranial factors of secondary cerebral damage. Zhurnal im. N.V. Sklifosovskogo Neotlozhnaya meditsinskaya pomoshch’. 2012; 1: 56–65 (in Russ.)].
  7. Sosnovskij E.A., Puras Ju.V., Talypov A.E. Biohimicheskie markery cherepno-mozgovoj travmy. Nejrohirurgija. 2014; 2: 83–91 [Sosnovsky E.A., Puras J.V., Talypov A.E. Biochemical markers of head injury. Russian journal of neurosurgery. 2014; 2: 83–91 (in Russ.)]. https://doi.org/10.17650/1683-3295-2014-0-2-83-91
  8. Karimov R.H., Danilov V.I. Cherepno-mozgovoj travmatizm v g. Kazani. Kazanskij meditsinskij zhurnal. 2006; 87 (3): 229–32 [Karimov R.H., Danilov V.I. Traumatic brain injury in Kazan. Kazanskii meditsinskii zhurnal. 2006; 87 (3): 229–32 (in Russ.)].
  9. Puras Ju.V., Kordonskij A.Ju., Talypov A.E. Mehanizmy evoljutsii ochagov ushiba golovnogo mozga. Nejrohirurgija. 2013; 4: 91–6 [Puras J.V., Kordonsky A.J., Talypov A.E. Mechanisms of brain contusion foci progression. Russian journal of neurosurgery. 2013; 4: 91–6 (in Russ.)]. https://doi.org/10.17650/1683-3295-2013-0-4-91-96
  10. Puras Ju.V., Talypov A.E., Trifonov I.S. i dr. Sudorozhnyj sindrom v ostrom periode tjazheloj cherepno-mozgovoj travmy. Nejrohirurgija. 2011; 2: 35–40 [Puras Yu.V., Talypov A.E., Trifonov I.S. et al. Convulsive syndrome in the acute period of severe traumatic brain injury. Russian journal of neurosurgery. 2011; 2: 35–40 (in Russ.)].
  11. Schedrenok V.V., Moguchaja O.V., Jakovenko I.V. i dr. Analiz bol'nichnoj letal'nosti u postradavshih s sochetannoj cherepno-mozgovoj travmoj v Sankt-Peterburge i voprosy kachestva meditsinskoj pomoschi. Vestnik hirurgii im. I.I. Grekova. 2007; 166 (5): 82–5 [Schedrenok V.V., Moguchaya O.V., Yakovenko I.V. et al. An analysis of hospital mortality of casualties with combined cerebro-cranial traumas in St. Petersburg and problems of the quality of medical care. Grekov’s Bulletin of Surgery. 2007; 166 (5): 82–5 (in Russ.)].
  12. Puras Ju.V., Talypov A.E., Krylov V.V. Dekompressivnaja trepanatsija cherepa v rannem periode tjazheloj cherepno-mozgovoj travmy. Nejrohirurgija. 2011; 3: 19–26 [Puras Ju.V., Talypov A.E., Krylov V.V. Decompressive craniotomy in acute period of severe head injury. Russian journal of neurosurgery. 2011; 3: 19–26 (in Russ.)].
  13. Talypov A.E., Mjatchin M.Ju., Kuksova N.S. i dr. Primenenie tserebrolizina u bol'nyh s ushibom golovnogo mozga srednej stepeni tjazhesti. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2014; 114 (11): 98–106 [Talypov A.E., Miatchin M.Iu., Kuksova N.S. et al. Cerebrolysin in the treatment of brain injuries of moderate severity. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2014; 114 (11): 98–106 (in Russ.)].
  14. Morozov S.A., Scherbuk Ju.A., Gajvoronskij A.I. i dr. Kliniko-morfologicheskie korreljatsii pri travmaticheskih vnutricherepnyh gematomah. Vestnik Sankt-Peterburgskogo universiteta. Meditsina. 2011; 2: 34–40 [Morozov S.A., Shcherbuk Yu. A.1, Gaivoronsky A.I. et al. Clinicomorpologic correlations during traumatic intracranial haematomas. Vestnik Sankt-Peterburgskogo universiteta. Meditsina. 2011; 2: 34–40 (in Russ.)].
  15. Talypov A.E., Mjatchin M.Ju., Kuksova N.S. i dr. Medikamentoznaja nejroprotektsija v ostrom periode cherepno-mozgovoj travmy srednej stepeni tjazhesti. Meditsinskij sovet. 2015; 10: 82–92 [Talypov A.E., Myatchin M.Y., Kuksova N.S. et al. Drug-based neuroprotection in acute phase of traumatic brain injury of moderate severity. Meditsinskiy sovet = Medical Council. 2015; 10: 82–92 (in Russ.)]. https://doi.org/10.21518/2079-701X-2015-10-82-92
  16. Lavrenjuk A.N., Kravets L.Ja., Smirnov P.V. i dr. K ponjatiju «travmaticheskie parenhimatoznye povrezhdenija golovnogo mozga». Voprosy travmatologii i ortopedii. 2011; 1: 26–30 [Lavrenyuk A.N., Kravets L.Ya., Smirnov P.V. et al. To the term notion «Traumatic parenchymatousdamages of head brain». Voprosy travmatologii i ortopedii. 2011; 1: 26–30 (in Russ.)].
  17. Talypov A.E., Golovko S., Ioffe Ju.S. i dr. Oshibki diagnostiki pri travmaticheskih vnutricherepnyh gematomah. Chast' 2. Nejrohirurgija. 2009; 1: 68–73 [Talypov A.E., Golovko S.M., Yoffe Yu.S. et al. Misdiagnoses of the traumatic intracranial haematomas. Part 2. Russian journal of neurosurgery. 2009; 1: 68–73 (in Russ.)].
  18. Ioffe Ju.S., Talypov A.E., Mjatchin M.Ju. i dr. Lechenie ushibov golovnogo mozga legkoj i srednej stepeni tjazhesti s primeneniem aktovegina. Nejrohirurgija. 2008; 1: 38–43 [loffe Y.S., Talypov A.E., Myatchin M.Y. et al. Actovegin administration in the course of treatment of mild or moderate cerebral contusion. Russian journal of neurosurgery. 2008; 1: 38–43 (in Russ.)].
  19. Puras Ju.V., Talypov A.E. Faktory riska razvitija neblagoprijatnogo ishoda v hirurgicheskom lechenii ostroj cherepno-mozgovoj travmy. Nejrohirurgija. 2013; 2: 8–16 Puras J.V., Talypov A.E. Risk factors for unfavorable outcome in surgical treatment of acute head injury. Russian journal of neurosurgery. 2013; 2: 8–16 (in Russ.)]. https://doi.org/10.17650/1683-3295-2013-0-2-8-16
  20. Fraerman A.P. Travmaticheskoe sdavlenie golovnogo mozga: sovremennye aspekty problemy, taktika lechenija. Sovremennye tehnologii v meditsine. 2011; 4: 146–50 [Fraerman A.P. Traumatic brain compression: modern aspects of the problem, management. Sovremennye tekhnologii v meditsine. 2011; 4: 146–50 (in Russ.)].
  21. Puras Ju.V., Talypov A.E., KordonskijA.Ju. Mehanizmy vtorichnogo povrezhdenija mozga i nejrotroficheskoe dejstvie tserebrolizina pri cherepno-mozgovoj travme. Nejrohirurgija. 2012; 4: 94–102 [Puras Yu.V., Talypov A.E., Kordonskiy A.Yu. The mechanisms of secondary brain injury and neurotrophic effect of cerebrolysin in traumatic brain injury. Russian journal of neurosurgery. 2012; 4: 94–102 (in Russ.)].
  22. Krylov V.V., Talypov A.E., Puras Ju.V. i dr. Vtorichnye faktory povrezhdenij golovnogo mozga pri cherepno-mozgovoj travme. Rossijskij meditsinskij zhurnal. 2009; 3: 23–8 [Krylov V.V., Talypov A.E., Puras Yu.V. et al. Secondary brain lesion factors in head injury. Rossiiskii meditsinskii zhurnal. 2009; 3: 23–8 (in Russ.)].
  23. Fraerman A.P., Kravets L.Ja., Sheludjakov A.Ju. i dr. Sdavlenie golovnogo mozga pri izolirovannoj i sochetannoj cherepno-mozgovoj travme. Povolzh'e, 2008; 328 s. [Fraerman A.P., Kravec L.Ya., Sheludyakov A.Yu. et al. Compression of the brain in an isolated and combined traumatic brain injury. Povolzh’e, 2008; 328 p. (in Russ.)].
  24. Krylov V.V., Puras Ju.V. Patofiziologicheskie mehanizmy vtorichnogo povrezhdenija mozga pri cherepno-mozgovoj travme. Nevrologicheskij zhurnal. 2013; 18 (4): 4–7 [Krylov V.V., Puras Yu.V. Pathophysiologic mechanisms of the secondary brain damage after craniocerebral trauma. Nevrologicheskii zhurnal. 2013; 18 (4): 4–7 (in Russ.)].
  25. Puras Ju.V., Talypov A.E., Kordonskij A.Ju. Mehanizmy vtorichnogo povrezhdenija mozga i nejrotroficheskoe dejstvie Tserebrolizina pri cherepno-mozgovoj travme. Nejrohirurgija. 2012; 4: 94–102 [Puras Yu.V., Talypov A.E., Kordonskiy A.Yu. The mechanisms of secondary brain injury and neurotrophic effect of cerebrolysin in traumatic brain injury. Russian journal of neurosurgery. 2012; 4: 94–102 (in Russ.)].
  26. Carney N., Totten A.M., O’Reilly C. et al. Guidelines for the management of severe traumatic brain injury. J Neurosurgery. 2017; 80 (1): 6–15. https://dx.doi.org/10.1227/NEU.0000000000001432
  27. Krylov V.V., Puras Ju.V. Klinicheskaja otsenka tjazhesti ostrogo dislokatsionnogo sindroma pri tjazheloj cherepno-mozgovoj travme. Nevrologicheskij zhurnal. 2014; 19 (2): 18–22 [Krylov V.V., Puras Yu.V. Clinical assessment a severity of acute dislocation syndrome in patients with severe brain injury. Nevrologicheskii zhurnal. 2014; 19 (2): 18–22 (in Russ.)].
  28. Klimash A.V., Kondakov E.N. Harakteristika dislokatsionnogo sindroma pri supratentorial'nom sdavlenii golovnogo mozga u bol'nyh s tjazheloj cherepno-mozgovoj travmoj (Chast' I). Nejrohirurgija. 2015; 3: 3–10 [Klimash A.V., Kondakov E.N. The characteristics of dislocation syndrome in the case of supratentorial compression of brain at patients with severe head injury (part 1). Russian journal of neurosurgery. 2015; 3: 3–10 (in Russ.)].
  29. Krylov V.V., Talypov A.E., Puras Ju.V. Vybor trepanatsii v hirurgii tjazheloj cherepno-mozgovoj travmy. Voprosy nejrohirurgii im. N.N. Burdenko. 2007; 1: 11–6 [Krylov V.V., Talypov A.E., Puras YU.V. The choice of trepanation in surgery for severe traumatic brain injury. Voprosy neirokhirurgii im. N.N. Burdenko. 2007; 1: 11–6 (in Russ.)].
  30. Krylov V.V., Talypov A.E., Puras Ju.V. Vnutricherepnoe davlenie pri povrezhdenijah golovnogo mozga. Nejrohirurgija. 2007; 4: 12–9 [Krylov V.V., Taypov A.E., Puras Y.V. Intracranial pressure in patients with cerebral injury. Russian journal of neurosurgery. 2007; 4: 12–9 (in Russ.)].
  31. Midori I.M., Bersnev V.P., Rjabuha N.P. Sindrom sdavlenija golovnogo mozga pri cherepno-mozgovoj travme. Vestnik hirurgii im. I.I. Grekova. 2012; 171 (6): 66–8 [Midori I.M., Bersnev V.P., Ryabukha N.P. Syndrome of brain compression in cranio-cerebral trauma. Grekov’s Bulletin of Surgery. 2012; 171 (6): 66–8 (in Russ.)]. https://doi.org/10.24884/0042-4625-2012-171-6-066-068
  32. Garifullin R.F., Danilov V.I., Karimov R.H. Reaktivnost' tserebral'nyh sosudov u patsientov s ochagami ushiba golovnogo mozga i vozmozhnosti ee farmakologicheskoj korrektsii. Kazanskij meditsinskij zhurnal. 2016; 97 (6): 903–8 [Garifullin R.F., Danilov V.I., Karimov R.H. Cerebrovascular reactivity in patients with cerebral contusion and its possible pharmacological correction. Kazan medical journal. 2016; 97 (6): 903–8 (in Russ.)]. DOI: 10.17750/KMJ2016-903
  33. Puras Ju.V., Talypov A.E. Vlijanie arterial'noj gipotenzii v dogospital'nom periode na ishod hirurgicheskogo lechenija postradavshih s tjazheloj cherepno-mozgovoj travmoj. Meditsina katastrof. 2010; 3: 27–31 [Puras Yu.V., Talypov A.E. The effect of arterial hypotension in the prehospital period on the outcome of surgical treatment of patients with severe traumatic brain injury. Meditsina katastrof. 2010; 3: 27–31 (in Russ.)].
  34. Schedrenok V.V., Moguchaja O.V., Jakovenko I.V. i dr. Osobennosti kliniki sochetannoj cherepno-mozgovoj travmy. Vestnik hirurgii im. I.I. Grekova. 2008; 167 (4): 40–2 [Shchedrenok V.V., Moguchaya O.V., Yakovenko I.V. et al. Peculiar features of the clinical picture of associated cranio-cerebral trauma. Grekov’s Bulletin of Surgery. 2008; 167 (4): 40–2 (in Russ.)].
  35. Kravets L.Ja., Smirnov P.V., Lavrenjuk A.N. Dinamika ochagovyh travmaticheskih parenhimatoznyh povrezhdenij golovnogo mozga v ostrom periode legkoj cherepno-mozgovoj travmy. Nejrohirurgija. 2016; 2: 16–23 [Kravetc L., Smirnov P., Lavrenuk A. Dynamics of focal traumatic parenchymal injuries of brain in acute period of mild traumatic brain injury. Russian journal of neurosurgery. 2016; 2: 16–23 (in Russ.)].
  36. Chang E.F., Meeker M.., Holland M. C. Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period. Neurosurgery. 2006; 58 (4): 647–56. DOI: 10.1227/01.NEU.0000197101.68538.E6
  37. Greenberg M.S. Handbook of Neurosurgery, 7th ed. N-Y: Thieme, 2010; 1352 p.
  38. Fraerman A.P., Syrkina N.V., Zhelezin O.V. i dr. Sochetannaja cherepno-mozgovaja travma. Povolzh'e, 2015; 204 s. [Fraerman A.P., Syrkina N.V., Zhelezin O.V. et al. Combined head injury. Povolzh’e, 2015; 204 p. (in Russ.)].
  39. Fraerman A.P. Cherepno-mozgovaja travma. Nizhnij Novgorod: NizhGMA, 2011; 108 s. [Fraerman A.P. Traumatic brain injury. Nizhnij Novgorod: NizhGMA, 2011; 108 p. (in Russ.)].
  40. Lebedev V.V., Krylov V.V., Martynenko A.V. i dr. Kliniko-komp'juterno-tomograficheskaja klassifikatsija ushibov golovnogo mozga. Nejrohirurgija. 2001; 1: 25–36 [Lebedev V.V., Krylov V.V., Martynenko A.V. et al. Clinical CT classification of brain contusions. Russian journal of neurosurgery. 2001; 1: 25–36 (in Russ.)].
  41. Kornienko V.N., Pronin I.N. Diagnosticheskaja nejroradiologija v 5 t. M.: Vidar, 2009; T. 3: 463 s [Kornienko V.N., Pronin I.N. Diagnostic neuroradiology in 5 volumes. M.: Vidar, 2009; T. 3: 463 p. (in Russ.)].
  42. Krylov V.V., Talypov A.E., Kordonskij A.Ju. Progressirovanie ochagov ushiba golovnogo mozga: varianty i faktory riska. Rossijskij nejrohirurgicheskij zhurnal imeni professora A.L. Polenova. 2014; 6 (3): 37–45 [Krylov V.V., Talypov A.E., Kordonskij A.Yu. Progression of foci of brain contusion: options and risk factors. Rossiiskii neirokhirurgicheskii zhurnal imeni professora A.L. Polenova. 2014; 6 (3): 37–45 (in Russ.)].
  43. Kravets L.Ja., Smirnov P.V., Kukarin A.B. Vybor metoda lechenija pri ushibah golovnogo mozga. Nejrohirurgija. 2017; 1: 8–14 [Kravets L.Y., Smirnov P.V., Kukarin A.B. The selection of treatment strategy for patients suffered from traumatic brain contusions. Russian journal of neurosurgery. 2017; 1: 8–14 (in Russ.)].
  44. Puras Ju.V., Grigor'eva E.V. Metody nejrovizualizatsii v diagnostike cherepno-mozgovoj travmy. Chast' 1. Komp'juternaja i magnitno-rezonansnaja tomografija. Nejrohirurgija. 2014; 2: 7–16 [Puras J.V., Grigorieva E.V. The neurovisualization methods in diagnostics of head injury. Part 1. Computer tomography and magnetic resonance imaging. Russian journal of neurosurgery. 2014; 2: 7–16 (in Russ.)]. https://doi.org/10.17650/1683-3295-2014-0-2-7-16
  45. Smirnov P.V., Kravets L.Ja., Jakimov V.N. Rannjaja komp'juternaja tomografija pri ushibah golovnogo mozga. Nejrohirurgija. 2017; 2: 21–8 [Smirnov P.V., Kravets L.Y., Yakimov V.N. Early computer tomography in patients with brain contusions. Russian journal of neurosurgery. 2017; 2: 21–8 (in Russ.)].
  46. Potapov A.A., Krylov V.V., Gavrilov A.G. i dr. Rekomendatsii po diagnostike i lecheniju tjazheloj cherepno-mozgovoj travmy. Chast' 2. Intensivnaja terapija i nejromonitoring. Voprosy nejrohirurgii im. N.N. Burdenko. 2016; 80 (1): 98–106 [Potapov A.A., Krylov V.V., Gavrilov A.G. et al. Guidelines for the diagnosis and treatment of severe traumatic brain injury. Part 2. Intensive care and neuromonitoring. Burdenko’s Journal of Neurosurgery = Zhurnal “Voprosy neirokhirurgii” imeni N.N. Burdenko. 2016; 80 (1): 98–106 (in Russ.)]. https://doi.org/10.17116/neiro201680198-106
  47. Chernij T.V., Stetsik V.Ju., Chernij V.I. Cherepno-mozgovaja travma v aspekte dokazatel'noj meditsiny: obzor aktual'nyh mezhdunarodnyh rekomendatsij. Meditsina neotlozhnyh sostojanij. 2014; 5 (60): 16–9 [Chernij T.V., Stecik V.YU., Chernij V.I. Traumatic brain injury in the aspect of evidence-based medicine: a review of relevant international recommendations. Meditsina neotlozhnykh sostoyanii. 2014; 5 (60): 16–9 (in Russ.)].
  48. Puras Ju.V., Talypov A.E., Krylov V.V. Dekompressivnaja trepanatsija cherepa v rannem periode tjazheloj cherepno-mozgovoj travmy. Nejrohirurgija. 2011; 3: 19–26 [Puras Ju.V., Talypov A.E., Krylov V.V. Decompressive craniotomy in acute period of severe head injury. Russian journal of neurosurgery. 2011; 3: 19–26 (in Russ.)].
  49. Maloney-Wilensky E., Gracias V., Itkin A. et al. Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review. Crit Care Med. 2009; 37 (6): 2057–63. DOI: 10.1097/ccm.0b013e3181a009f8
  50. Talypov A.E., Kordonskij A.Ju., Krylov V.V. Mezhdunarodnye mnogotsentrovye issledovanija po lecheniju tjazheloj cherepno-mozgovoj travmy. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2016; 116 (1): 113–21 [Talypov A.E., Kordonsky A.Yu., Krylov V.V. International multicenter studies of treatment of severe traumatic brain injury. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2016; 116 (1): 113–21 (in Russ.)]. DOI: 10.17116/jnevro201611611113-121