THE CLINICAL AND PATHOPHYSIOLOGICAL FEATURES OF ASTHMA-CHRONIC OBSTRUCTIVE PULMONARY DISEASE OVERLAP SYNDROME
Issue:
2
Year:
2017
In clinical practice, asthma and chronic obstructive pulmonary disease (COPD) are easily distinguishable; however, the asthma-COPD overlap syndrome (OS) in a patient causes both diagnostic and therapeutic challenges. The phenotype of the asthma-COPD OS is characterized by a worse prognosis than that of isolated diseases of asthma or COPD. OS is characterized by a concurrence of eosinophilic and neutrophilic inflammation in the respiratory tract, which is accompanied by obvious obstruction of the distal bronchi and bronchospasm. Patients with OS are a population different from those with asthma or COPD; and the identification of such persons into a special group is justified and appropriate in the context of pathophysiology, clinical presentations, and therapy.
Keywords:
asthma
chronic obstructive pulmonary disease
overlap syndrome
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