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THE CLINICAL AND PATHOPHYSIOLOGICAL FEATURES OF ASTHMA-CHRONIC OBSTRUCTIVE PULMONARY DISEASE OVERLAP SYNDROME

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Issue: 
2
Year: 
2017

Professor Zh. Mironova, MD; E. Vsevolodskaya; V. Belash; Professor V. Trofimov, MD; A. Ulitina, Candidate of Medical Sciences; S. Pchelina, Biol.D; Professor M. Dubina, MD, Academician of the Russian Academy of Sciences; S. Gorbunkov, Candidate of Medical Sciences; Professor A. Akopov, MD Acad. I.P. Pavlov First Saint Petersburg State Medical University

In clinical practice, asthma and chronic obstructive pulmonary disease (COPD) are easily distinguishable; however, the asthma-COPD overlap syndrome (OS) in a patient causes both diagnostic and therapeutic challenges. The phenotype of the asthma-COPD OS is characterized by a worse prognosis than that of isolated diseases of asthma or COPD. OS is characterized by a concurrence of eosinophilic and neutrophilic inflammation in the respiratory tract, which is accompanied by obvious obstruction of the distal bronchi and bronchospasm. Patients with OS are a population different from those with asthma or COPD; and the identification of such persons into a special group is justified and appropriate in the context of pathophysiology, clinical presentations, and therapy.

Keywords: 
asthma
chronic obstructive pulmonary disease
overlap syndrome



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