The course of pregnancy and perinatal complications in pregnant women with newly diagnosed urinary tract infection

DOI: https://doi.org/10.29296/25877305-2024-08-12
Issue: 
8
Year: 
2024

Professor E. Stepankova, MD; A. Sukhorukova
Smolensk State Medical University, Ministry of Health of Russia

Purpose. To analyze the course of pregnancy and perinatal complications in pregnant women with newly diagnosed urinary tract infection. Material and methods. Complications of pregnancy and early perinatal complications were analyzed in 97 pregnant women (main group) with newly diagnosed asymptomatic bacteriuria. The control group consisted of 50 pregnant women without clinical and laboratory signs of urinary tract infections. Results. In the main group, in most cases, a monoinfection was isolated from the urine; Enterobacteriaceae were the predominant uropathogens. In the main group, mild iron deficiency anemia was detected significantly more often than in the control group (p 0.05) – in 43 (44.3%) women, vaginitis – in 45 (46.4%), changes in the structure of the placenta according to ultrasound diagnosis – in 18 (18.5%). In the main group, there was a tendency towards a decrease in fetal adaptation according to cardiotocography, as well as a higher risk of intrauterine infection, umbilical cord entanglement and the formation of intrauterine malformations. Conclusion. Pregnant women with newly diagnosed asymptomatic bacteriuria of the tract are at risk of developing anemia, vaginitis, and also require additional diagnostics of the state of the fetoplacental system.
Keywords: 
obstetrics and gynecology
urinary tract infections
pregnancy
complications.

References: 
  1. Urinary tract infections in pregnant individuals. Obstet Gynecol. 2023; 142 (2): 435–45. DOI: 10.1097/AOG.0000000000005269
  2. Кульчавеня Е.В., Трейвиш Л.С., Телина Е.В. и др. Бессимптомная бактериурия у беременных: всегда ли оправдана антибиотикотерапия? Экспериментальная и клиническая урология. 2023; 16 (3): 112–8 [Kulchavenya E.V., Treyvish L.S., Telina E.V., et al. Asymptomatic bacteriuria in pregnant women: is antibiotic therapy always justified? Experimental and Clinical Urology. 2023; 16 (3): 112–8 (in Russ.)]. DOI: 10.29188/2222-8543-2023-16-3-112-118
  3. Rafat D., Agrawal A., Khalid S. et al. Bacterial abundance and antimicrobial resistance patterns of uropathogens among pregnant women with asymptomatic bacteriuria: Association with glycemic status. Eur J Obstet Gynecol Reprod Biol X. 2023; 21: 100263. DOI: 10.1016/j.eurox.2023.100263
  4. Radu V.D., Vicoveanu P., Cărăuleanu A. et al. Pregnancy Outcomes in Patients with Urosepsis and Uncomplicated Urinary Tract Infections-A Retrospective Study. Medicina (Kaunas). 2023; 59 (12): 2129. DOI: 10.3390/medicina59122129
  5. Bratosin F., Folescu R., Krupyshev P. et al. Comparative Analysis of Microbial Species and Multidrug Resistance Patterns Associated with Lower Urinary Tract Infections in Preterm and Full-Term Births. Microorganisms. 2024; 12 (1): 139. DOI: 10.3390/microorganisms12010139
  6. Sung J., Larsen P., Halverson T.M. et al. First trimester "clean catch" urine and vaginal swab sample distinct microbiological niches. Microbiol Spectr. 2024; 12 (1): e0263823. DOI: 10.1128/spectrum.02638-23
  7. Khapre M., Sharma D., Mehta A. et al. Prevalence of Asymptomatic Bacteriuria (ASB) in Pregnant Women in India: A Systematic Review and Meta-Analysis. Indian J Community Med. 2023; 48 (6): 879–87. DOI: 10.4103/ijcm.ijcm_795_22
  8. Wingert A., Pillay J., Sebastianski M. et al. Asymptomatic bacteriuria in pregnancy: systematic reviews of screening and treatment effectiveness and patient preferences. BMJ Open. 2019; 9 (3): e021347. DOI: 10.1136/bmjopen-2017-021347
  9. Коган М.И., Набока Ю.Л., Гудима И.А. и др. Асимптоматическая бактериурия у беременных – нормальное состояние мочи здоровой женщины. Урология. 2022; 6: 5–8 [Kogan M.I., Naboka Y.L., Gudima I.A. et al. Asymptomatic bacteriuria in pregnant women – the normal condition of healthy women urine. Urologiia. 2022; 6: 5–8 (in Russ.)]. DOI: 10.18565/urology.2022.6.5-8
  10. Коган М.И., Набока Ю.Л., Гудима И.А. и др. Микробиота свежевыделенной средней порции мочи у женщин в I триместре беременности (пилотное исследование). Проблемы репродукции. 2023; 29 (5): 73–8 [Kogan M.I., Naboka Yu.L., Gudima I.A., et al. Microbiota of freshly extracted midstream urine in women in the first trimester of pregnancy (pilot study). Russian Journal of Human Reproduction. 2023; 29 (5): 73–8 (in Russ.)]. DOI: 10.17116/repro20232905173
  11. Зефирова Т.П., Железова М.Е., Ахметшина И.И. Спорные вопросы диагностики и лечения бессимптомной бактериурии у беременных женщин. Практическая медицина. 2018; 6: 34–8 [Zefirova T.P., Zhelezova M.E., Akhmetshina I.I. Disputable issues of diagnosing and treatment of asymptomatic bacteriuria in pregnant women. Practical Medicine. 2018; 6: 34–8 (In Russ)].
  12. Moore A., Doull M., Grad R. et al. Canadian Task Force on Preventive Health Care. Recommendations on screening for asymptomatic bacteriuria in pregnancy. CMAJ. 2018; 190 (27): E823-E830. DOI: 10.1503/cmaj.171325