A. Dudnikova(1), Сandidate of Medical Sciences; E. Sokolova(2); P. Poltorackaya(2);
A. Storozhenko(2); D. Simakov(2); Z. Dorohin(2)
1-Clinic of Kuban State Medical University, Ministry of Health of Russia, Krasnodar
2-Kuban State Medical University, Ministry of Health of Russia, Krasnodar

Recent research has made it possible to expand and complement the modern understanding of the regulation of many physiological processes of the body. At the same time, there are many controversial questions about the role of increasing homocysteine levels in the development of certain diseases, mainly cardiovascular pathology. Purpose. To analyze the current literature on the contribution of hyperhomocysteinemia to the formation of cardiovascular diseases (CVD). Material and methods. The data of foreign and domestic articles on the research topic found in Pubmed and eLibrary and published over the past 7 years are analyzed. Conclusions. Hyperhomocysteinemia leads to amplification of the adverse effects of classical CVD risk factors such as hypertension, smoking, lipid metabolism by participating in the formation of endothelial dysfunction.

cardiovascular risk
folate cycle gene polymorphism
vitamin B12
folic acid.

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