THE SEVERITY OF VASCULAR INFLAMMATION AND ITS RELATIONSHIP WITH CLINICAL AND FUNCTIONAL FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITHOUT CONCOMITANT CARDIOVASCULAR PATHOLOGY

DOI: https://doi.org/10.29296/25877305-2024-02-05
Issue: 
2
Year: 
2024

Associate Professor T. Tayutina(1), Candidate of Medical Sciences; N. Klimenko(1), Candidate of Medical Sciences; Professor D. Kudlay(2–4), Corresponding Member of the Russian Academy of Sciences, MD; Professor L. Shovkun(1), MD; N. Nikolenko(5), Candidate of Pharmaceutical Sciences
1-Rostov State Medical University, Ministry of Health of Russia, Rostov-on-Don
2-I.M. Sechenov First Moscow State Medical University, Ministry of Health
of Russia (Sechenov University)
3-M.V. Lomonosov Moscow State University
4-National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
5-The Moscow Research and Clinical Center for Tuberculosis Control
of the Moscow government department of health

The Russian Federation is one of the countries with a high prevalence of chronic obstructive pulmonary disease (COPD). In the last decade, the list of families of chemical regulators of vascular inflammation in COPD has been supplemented with information about growth factors, whose participation in the processes of regulation of vascular function seems significant. The study of the role of angiogenesis factors in patients with isolated COPD disease is insufficient at this stage and needs to be clarified. Objective. To study was to identify diagnostic and prognostic criteria for the severity of vascular inflammation and to assess its relationship with clinical and functional features in patients with COPD without concomitant cardiovascular pathology in comparison with the clinical phenotype of the disease. Material and methods. 96 patients with COPD were examined, the median age was 61 years. In addition to standard clinical, functional and laboratory research methods, the severity of vascular inflammation was assessed in all examined patients with the determination of quantitative indicators of human platelet growth AA factor and tumor necrosis factor-α (TNFα) by quantitative solid-phase enzyme immunoassay Results. In all patients with isolated COPD, regardless of the risk of developing the underlying disease, an increase in the level of platelet growth AA factor and TNFα was noted. The level of platelet growth AA factor and TNFα in patients with COPD, regardless of the risk of exacerbation, was correlated with the functional state of the lungs, clinical phenotype and severity of clinical manifestations of the disease. The value of platelet growth AA factor above 317 ng/ml in patients with COPD may be an early marker of endothelial dysfunction and a predictor of the development of hemostatic disorders and concomitant cardiovascular pathology.
Keywords: 
chronic obstructive pulmonary disease
angiogenesis
platelet growth AA factor
tumor necrosis factor
vascular inflammation.

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