Epicardial fat ectopy in women with different estradiol levels

DOI: https://doi.org/10.29296/25877305-2024-01-08
Issue: 
1
Year: 
2024

M. Zimina; S. Dora, MD; I. Lygdenova; T. Yusipova, Candidate of Medical Sciences; M. Butomo, Candidate of Medical Sciences; A. Volkova, MD; Professor Yu. Khalimov, MD
I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health
of Russia

Objective. To establish the early risk factors of metabolic syndrome in women with decreased ovarian reserve, premature and early menopause; to estimate the thickness of epicardial fat and the levels of estradiol and anti-mullerian hormone (AMH) in women with early estrogen deficiency and in control subjects without estrogen deficiency, to evaluate the effect of estrogen replacement hormone therapy on epicardial fat thickness and the change of arterial pressure (BP) parameters. Material and Methods. Group 1 (n=12) included patients with co-preserved menstrual cycle and AMH >1 ng/ml, Group 2 (n=10) included patients with preserved menstrual cycle and AMH

Keywords: 
epicardial adipose tissue
premature ovarian exhaustion syndrome
premature menopause
cardiovascular risks
ovarian reserve.



References: 
  1. Ford E.A., Beckett E.L., Roman S.D. et al. Advances in human primordial follicle activation and premature ovarian insufficiency. Reproduction. 2020; 159 (1): R15–R29. DOI: 10.1530/REP-19-0201
  2. Rudnicka E., Kruszewska J., Klicka K. et al. Premature ovarian insufficiency – aetiopathology, epidemiology, and diagnostic evaluation. Prz Menopauzalny. 2018; 17 (3): 105–8. DOI: 10.5114/pm.2018.78550
  3. Golezar S., Ramezani Tehrani F. et al. The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis. Climacteric. 2019; 22 (4): 403–11. DOI: 10.1080/13697137.2019.1574738
  4. Paschou S.A., Augoulea A. Lambrinoudaki I. Premature ovarian insufficiency. Eur Gynecol Obst J. 2020; 2: 5–9.
  5. Conway G.S. Premature ovarian insufficiency, menopause, and hormone replacement therapy. In: Advanced Practice in Endocrinology Nursing. Cham: Springer International Publishing, 2019; рр. 803–15. DOI: 10.1007/978-3-319-99817-6_41
  6. Хабибулина М. Психовегетативный статус и безболевая ишемия миокарда в пременопаузе при метаболически здоровом ожирении. Врач. 2019; 30 (4): 79–83 [Khabibulina M. Psychoautonomic status and silent myocardial ischemia in premenopause in the presence of metabolically healthy obesity. Vrach. 2019; 30 (4): 79–83 (in Russ.)]. DOI: 10.29296/25877305-2019-04-15
  7. Хабибулина М.М. Влияние альтернативного варианта заместительной гормональной терапии на кардиальные проявления при метаболически здоровом ожирении и гипоэстрогенемии. Фармация. 2022; 71 (4): 46–51 [Khabibulina M.M. The influence of an alternative variant of hormone replacement therapy on cardiac manifestations in metabolically healthy obesity and hypoestrogenemia. Pharmacy. 2022; 71 (4): 46–51 (in Russ.)]. DOI: 10.29296/25419218-2022-04-07
  8. Iacobellis G. Epicardial Adipose Tissue: From Cell to Clinic. Contemporary Cardiology. SpringerLink, 2020; 191 р. DOI: 10.1007/978-3-030-40570-0
  9. Wong C.X., Ganesan A.N., Selvanayagam J.B. Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions. Eur Heart J. 2017; 38 (17): 1294–302. DOI: 10.1093/eurheartj/ehw045
  10. Sacks H., Symonds M.E.. Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes. Diabetes. 2013; 62 (6): 1783–90. DOI: 10.2337/db12-1430
  11. Frayn, Keith N. 2013. Metabolic Regulation: A Human Perspective, 3rd Edition. doi:10.1016/j.clnu.2010.12.002
  12. Poetsch M.S., Strano A., Guan K. Role of Leptin in Cardiovascular Diseases. Front Endocrinol. 2020; 11: 354. DOI: 10.3389/fendo.2020.00354
  13. Landecho M.F., Tuero C., Valenti V. et al. Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk. Nutrients. 2019; 11 (11): 2664. DOI: 10.3390/nu11112664