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A comparative study of lappaconitine hydrobromide extended release and propafenone in patients with paroxysmal atrial fibrillation

DOI: https://doi.org/10.29296/25877305-2024-01-04
Issue: 
1
Year: 
2024

Professor A. Revishvili(1), Academician of the Russian Academy of Sciences, MD; Professor S. Golitsyn(2), MD; S. Aksentiev(6), Candidate of Medical Sciences;
A. Amiraslanov(1); E. Artyukhina(1), MD; Professor D. Duplyakov(3), MD; E. Zubov(4), Candidate of Medical Sciences; E. Isaeva(5), Candidate of Medical Sciences; A. Loginova(2); T. Malkina(2), Candidate of Medical Sciences; G. Miloserdov(6); A. Rivin(7); S. Teplykh(8); I. Tsygankova(6); Professor Yu. Shvarts(9), MD; Yu. Yuricheva(2), Candidate of Medical Sciences; Professor S. Kanorsky(10), MD; S. Sokolov(2), Candidate of Medical Sciences
1-National Medical Research Center of Surgery named after A.Vishnevsky, Ministry of Health of Russia, Moscow
2-National Medical Research Centre of cardiology named after Academician
E.I. Chazov, Ministry of Health of Russia, Moscow
3-V.P. Polyakov Samara Region Clinical Cardiological Dispensary
4-LLC «Professor's Clinic», Perm
5-Interregional Clinical Diagnostic Center, Kazan
6-Regional Clinical Hospital, Ryazan
7-AntMed LLC, Saint Petersburg
8-LLC «Center for Professional Medicine», Perm
9-Saratov State Medical University named after V.I. Razumovsky
10-Kuban State Medical University, Ministry of Health of Russia, Krasnodar

A new dosage form of lappaconitine hydrobromide has been created – the long-acting drug Allaforte®, which has fewer side effects compared to the traditional dosage form (Allapinin®). Objective. To evaluate the effectiveness, safety and tolerability of Allaforte® therapy in comparison with the drug Rytmonorm® in patients with paroxysmal atrial fibrillation (AF). Material and methods. Patients who met the inclusion criteria and those who did not meet the non-inclusion criteria were randomized into 2 groups: 1st (n=50) – patients received Allaforte® 25 mg 3 times a day with an increase in dose to 50 mg 2 times a day when detected attack of AF; 2nd (n=50) – patients received Rytmonorm® 150 mg 3 times a day with an increase in dose to 300 mg 2 times a day if an attack of AF was detected. Results. The average time from the first dose of the drug to the development of AF paroxysm in the 1st group (Allaforte®) was 98.877±6.022 days, in the 2nd group (Rytmonorm®) – 98.808±5.876 days, the average time from the first dose of the drug to the completion of the study – 105.740±5.032 and 103.732±5.353 days, respectively. The drugs Allaforte® and Rytmonorm® equally improved the quality of life of patients. A comparative analysis in groups according to the severity of adverse events and their cause-and-effect relationship with the drug did not show significant differences. Conclusion. The study drugs showed comparable effectiveness in preventing attacks of AF with similar safety and tolerability.

Keywords: 
cardiology
atrial fibrillation
rhythm control
lappaconitine hydrobromide
propafenone.



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