Autoimmune gastritis: clinical picture, diagnosis, treatment


L. Abduragimova; I. Khlynov, MD; R. Khlynova; G. Moroz
Ural State Medical University, Ministry of Health of Russia, Yekaterinburg

The review includes the analysis of modern data about prevalence, clinical picture, endoscopic, morphological, immunological diagnosis and treatment of autoimmune gastritis (AIG). The incidence of AIG is 2–12% of all cases of chronic gastritis. The leading factor in pathogenesis is the formation of autoantibodies to parietal cells and intrinsic Castle factor. AIG is a significant risk factor for vitamin C, B12, and D deficiency. The clinical picture of AIG is nonspecific and may include gastroenterologic, hematologic, and neuropsychiatric syndromes. Morphological diagnosis is the most reliable method for assessing atrophic gastritis, allowing the assessment of the three dynamic stages of AIG. Immunological diagnostics include antibodies to parietal cells and are highly specific. There is no etiotropic and pathogenetic therapy for AIG. Cyanocobalamin replacement therapy is approved in clinical practice.

autoimmune gastritis
clinical picture
diagnostic standards
replacement therapy.

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