Indicators of hemostasis and fibrinolysis systems and systemic inflammatory response in patients with newly diagnosed sarcoidosis after COVID-19
DOI: https://doi.org/10.29296/25877305-2023-12-08
Issue:
12
Year:
2023
Objective. To study the indicators of hemostasis and fibrinolysis systems, as well as the systemic inflammatory response in patients with newly diagnosed sarcoidosis after infection caused by SARS-CoV-2.
Material and methods. A prospective analysis of the indicators of hemostasis and fibrinolysis systems, as well as the systemic inflammatory response of 20 patients with sarcoidosis, after COVID-19, who were on inpatient treatment in Central TB Research Institute. The patients were divided into 2 groups. The first group included 10 patients with sarcoidosis, who had suffered COVID-19 (the main group). The comparison group consisted of 10 patients with sarcoidosis without a history of COVID-19.
Results. It was found, that in patients with newly diagnosed sarcoidosis, who underwent COVID-19, there is a hypercoagulation shift in the hemostasis and fibrinolysis system. This was evidenced by a significant shortening of the indicators of APTT, PT and an increase in the level of D-dimer compared to both healthy and patients, who had not undergone COVID-19. In addition, laboratory manifestations of systemic inflammation were most pronounced in patients with sarcoidosis who underwent COVID-19. Probably, changes in the hemostasis and fibrinolysis system occurred within the framework of a systemic inflammatory response.
Keywords:
tuberculosis
COVID-19
systemic inflammatory response
hemostasis and fibrinolysis system.
References:
- Абдуллаев Р.Ю., Комиссарова О.Г. Лабораторные проявления короновирусной инфекции COVID-19. Врач. 2020; 31 (5): 3–6 [Abdullaev R., Komissarova O. Laboratory indicators of coronаvirus infection COVID-19. Vrach. 2020; 31 (5): 3–6. (in Russ.)]. DOI: 10.29296/25877305-2020-05-01
- Бородулина Е.А., Широбоков Я.Е., Гладунова Е.П. и др. Диагностика и фармакотерапия вирус-ассоциированных поражений легких. Клиническая фармакология и терапия. 2020; 29 (3): 61–6 [Borodulina E.A., Shirobokov Y.E., Gladunova E.P. et al. Virus-associated lung disease. Clin Pharmacol Ther. 2020; 29 (3): 61–6 (in Russ.)]. DOI: 10.32756/0869-5490-2020-3-61-66
- Визель А.А., Визель И.Ю., Амиров Н.Б. Эпидемиология саркоидоза в Российской Федерации. Вестник современной клинической медицины. 2017; 10 (5): 66–73 [Vizel А.А., Vizel I.Yu., Amirov N.B. Epidemiology of sarcoidosis in the Russian Federation. The Bulletin of Contemporary Clinical Medicine. 2017; 10 (5): 66–73 (in Russ.)]. DOI: 10.20969/VSKM.2017.10(5).66-73
- Старшинова А.А., Малкова А.М., Зинченко Ю.С. и др. Аутоиммунная составляющая в этиологии саркоидоза. Туберкулез и болезни легких. 2020; 98(5): 54–62 [Starshinova A.A., Malkova A.M., Zinchenko Yu.S., et al. Autoimmune component in the etiology of sarcoidosis. Tuberculosis and Lung Diseases. 2020; 98 (5): 54–62 (in Russ.)]. DOI: 10.21292/2075-1230-2020-98-5-54-62
- Brito-Zerón P., Gracia-Tello B., Robles A. et al. Characterization and Outcomes of SARS-CoV-2 Infection in Patients with Sarcoidosis. Viruses. 2021; 13 (6): 1000. DOI: 10.3390/v13061000
- Brito-Zerón P., Pérez-Álvarez R., Ramos-Casals M. Sarcoidosis. Med Clin (Barc). 2022; 159 (4):195–204. DOI: 10.1016/j.medcli.2022.03.009
- Capaccione K.M., McGroder C., Garcia C. K. et al. COVID-19-induced pulmonary sarcoid: A case report and review of the literature. Clin Imaging. 2022; 83: 152–8. DOI: 10.1016/j.clinimag.2021.12.021
- Hadi Y.B., Lakhani D.A., Naqvi S.F.Z. et al. Outcomes of SARS-CoV-2 infection in patients with pulmonary sarcoidosis: A multicenter retrospective research network study. Respir Med. 2021; 187: 106538. DOI: 10.1016/j.rmed.2021.106538
- Kahlmann V., Manansala M., Moor C.C. et al. COVID-19 infection in patients with sarcoidosis: susceptibility and clinical outcomes. Curr Opin Pulm Med. 2021; 27 (5): 463–71. DOI: 10.1097/MCP.0000000000000812
- Palones E., Pajares V., Lopez L. et al. Sarcoidosis following SARS-CoV-2 infection: Cause or consequence. Respirol Case Rep. 2022; 10 (6): e0955. DOI: 10.1002/rcr2.955
- Rabufetti A., Borradori L., Heidemeyer K. et al. New onset of sarcoidosis after COVID-19 infection. J Eur Acad Dermatol Venereol. 2022; 36 (10): e756-e759. DOI: 10.1111/jdv.18313
- Rossides M., Darlington P., Kullberg S. et al. Sarcoidosis: Epidemiology and clinical insights. J Intern Med. 2023; 293 (6): 668–80. DOI: 10.1111/joim.13629
- Starshinova A., Zinchenko Y., Malkova A. et al. Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants. Life (Basel). 2023; 13 (4): 1047. DOI: 10.3390/life13041047
- Strangfeld A., Schafer M., Gianfrancesco M.A. et al. Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry. Ann Rheum Dis. 2021; 80 (7): 930–42. DOI: 10.1136/annrheumdis-2020-219498
- Tang N., Li D., Wang X., et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020; 18 (4): 844–7. DOI: 10.1111/jth.14768