Cardiotoxic effects of antitumor therapy for colorectal cancer

DOI: https://doi.org/10.29296/25877305-2023-11-14
Issue: 
11
Year: 
2023

P. Klimkin(1), Candidate of Medical Sciences; Professor M. Shalenkova(2), MD;
E. Ovchinnikova(3), Candidate of Medical Sciences
1-City Clinical Hospital Fifth, Nizhny Novgorod
2-City Clinical Hospital Thirty-Eighth, Nizhny Novgorod
3-Nizhny Novgorod Regional Clinical Oncology Dispensary

Fluoropyrimidines (5-fluorouracil, capecitabine) are the main chemotherapeutic agents in the treatment of gastrointestinal oncologic pathology. However, therapy with these drugs may be associated with the development of cardiotoxic effects. The article discusses risk factors, the main proven mechanisms of cardiotoxic effects development; possible measures of primary and secondary prevention, peculiarities of fluoropyrimidines cardiotoxicity treatment are outlined. Clinical cases are presented that demonstrate the complexity of the pathophysiological mechanisms of development of fluoropyrimidine (capecitabine) cardiotoxicity and the difficulties of its prediction. In this case, drugs with a vasodilating effect can be effectively used as part of secondary prevention.
Keywords: 
antitumor therapy
colorectal cancer
adverse events
cardiotoxic effects
fluoropyrimidines
primary and secondary prevention.

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