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Modern view on the problem of keloid scars

DOI: https://doi.org/10.29296/25877305-2023-10-03
Issue: 
10
Year: 
2023

E. Dvoriankova(1, 2), MD; M. Karapetyan(3); G. Shevchenko(4); Professor
I. Korsunskaya(1), MD
1-Center for Theoretical Problems of Physicochemical Pharmacology,
Russian Academy of Sciences, Moscow
2-Bashkir State Medical University, Ufa
3-Moscow Research and Practical Center of Dermatovenereology and Cosmetology
4-Peoples’ Friendship University of Russia, Moscow

Serious skin injuries can lead to the formation of scars, in particular hypertrophic and keloid scars. The prevalence of keloids and hypertrophic scars varies among different populations. Scar formation is a natural process during wound healing, but when keloid scars form, regeneration is impaired. It is generally accepted that a keloid scar is formed as a result of increased synthesis of collagen and extracellular matrix against the background of reduced degradation of these products. Clinically, keloid and hypertrophic scars have a number of differences. Thus, the formation of a keloid scar takes a longer period; it extends beyond the boundaries of the original wound and is often accompanied by itching, pain, and impairs motor function. Treatment of keloid scars is a very difficult task, and inadequate treatment can aggravate the patient's condition.

Keywords: 
keloid scars
hypertrophic scars
pathogenesis of scars
therapy of keloid scars



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