The role of abnormal vaginal microbiocenosis in increasing the risk of adverse reproductive outcome


A. Megrabyan(1), Professor I. Ignatko(1), MD, Corresponding Member of the Russian Academy of Sciences ; D. Yakubova(1),Sh. Baibulatova(2)
1-I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
2-Clinical Hospital Four, Groznyi

Objective. To study vaginal microbiocenosis in pregnant women with poor perinatal outcome to determine the relationship between different types of perinatal infections and stillbirths. Subjects and methods. A retrospective study was conducted in 154 pregnant women divided into groups: a study group of 114 patients with antenatal fetal death at 22 weeks’ gestation; a control group of 40 patients with physiological pregnancy at the same time. Results. The patients in both groups were found to have statistically significant abnormal vaginal flora: coagulase-negative Staphylococcus (41.2%), Enterococcus faecalis (29.4%), Escherichia coli (44.1%), Staphylococcus aureus (11.1%), Klebsiella pneumoniae (12.9%), and Candida albicans (28.8%). At the same time, these abnormalities statistically significantly more commonly occurred in the study group. Conclusion. Of great importance is the determination of vaginal opportunistic pathogens in the prevention of adverse perinatal outcomes.

obstetrics and gynecology
intrauterine infections
antenatal fetal death
adverse perinatal outcomes.

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