Risk factors in the early diagnosis and prevention of osteoporosis in children: a rationale for pharmacological correction of calcium and vitamin D deficiency

DOI: https://doi.org/10.29296/25877305-2022-08-07
Issue: 
8
Year: 
2022

Professor V. Strukov(1), MD; Yu. Shcherbakova(3); D. Elistratov(2); Associate Professor D. Vikhrev(1), Candidate of Medical Sciences; Associate Professor N. Alekseeva(1), Candidate of Medical Sciences; Associate Professor L. Radchenko(1), Candidate of Medical Sciences; Associate Professor L. Musatova(3), Candidate of Medical Sciences; T. Kuptsova(1)
1-Penza Institute for Postgraduate Training of Physicians, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
2-Healthy Children Medical Center, Penza
3-Penza State University

The paper considers the role of risk factors (RFs) in the formation of low bone mineral density, starting with the prenatal period, early childhood and school age periods. An analysis has shown the characteristics of RFs in the examined children aged 9–17 years and their total negative effect on the development of osteoporosis and fractures in this category of patients. The paper also indicates a relationship of the frequency of bone fractures to the number of RFs risk factors and the presence of comorbidities. It provides a rationale for the pharmacological correction of vitamin D and calcium deficiency in children.
Keywords: 
pediatrics
risk factors
children
osteoporosis
repeated fractures
mineral density
prematurity
hypovitaminosis D
feeding
vitamin D deficiency
Osteomed Forte
Osteo-Vit D3.

References: 
  1. Peterkova V.A., Korovina N.A. et al. Defitsit kal’tsiya i osteopenicheskie sostoyaniya u detei: diagnostika, lechenie, profilaktika. Mezhdunarodnyi fond okhrany materi i rebenka. Nauchno-prakticheskaya programma. M.: 2006; s. 48. (in Russ.).
  2. Shcheplyagina L.A., Kruglova I.V., Moiseeva T.Yu. Istoki osteoporoza lezhat v detskom vozraste. Pediatriya. 2013; 1: 5–11 (in Russ.).
  3. Strukov V.I. Aktual’nye problemy osteoporoza. Rostra, 2009; 341 s. (in Russ.).
  4. Strukov V.I., Dzhouns O.V., Krutyakov E.N. et al. Sposob profilaktiki i lecheniya osteoporoza i perelomov kostei i preparat dlya profilaktiki i lecheniya osteoporoza i perelomov kostei. Patent na izobretenie №2498811. Prioritet izobreteniya ot 19.04.2012 (in Russ.).
  5. Shilin D.E. Epidemiologiya perelomov v detskom vozraste: obosnovanie farmakologicheskoi korrektsii defitsita kal’tsiya i vitamina D. Pediatriya. 2007; 3: 70–8 (in Russ.).
  6. Strukov V.I. et al Prevention of repeated fractures in children and teenagers with low bone mineral density. Lechashchii vrach. 2015; 6: 77–9 (in Russ.).
  7. Тaranushenko T.E., Kiseleva N.G. Paediatric osteoporosis: features of skeletal mineralization in children, prevention, and treatment. Meditsinskiy sovet = Medical Council. 2020; 10: 164–71 (in Russ.). DOI: 10.21518/2079-701X-2020-10-164-171
  8. Gromova O.A., Torshin I.Yu., Zakharova I.N. et al. Vitamin D defi ciency and comorbid conditions in children 7–16 years of age: intelligent data analysis. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2017; 4: 58–67 (in Russ.). DOI: 10.24411/2588-0519-2017-00031
  9. Soyuz pediatrov Rossii – Natsional’naya programma «Nedostatochnost’ vitamina D u detei i podrostkov Rossiiskoi Federatsii: sovremennye podkhody k korrektsii». M.: Pediatr, 2018; 96 s. (in Russ.).
  10. Kuptsova T., Kislov A., Strukov V. et al. Osteo-Vit D3 in the treatment of children with recurrent bone fractures in osteoporosis. Vrach. 2016; 1: 46–7 (in Russ.).