Effect of Femo-Klim on psycho-autonomic status, episodes of cardialgia in premenopausal women with metabolically healthy obesity and estrogen deficiency

DOI: https://doi.org/10.29296/25877305-2022-04-09
Issue: 
4
Year: 
2022

M. Khabibulina, Candidate of Medical Sciences; M. Shamilov
Ural State Medical University, Yekaterinburg

The paper gives the results of studying the effect of the natural non-hormonal remedy Femo-Klim on the psycho-autonomic and hormonal-metabolic statuses and episodes of cardialgia in women with metabolically healthy obesity (MHO) in the menopausal transition period (MTP). The investigation enrolled 94 patients with MHO in MTP. It revealed the association of estrogen deficiency with psycho-autonomic disorders, hypersympathicotonia, and cardialgia. The natural non-hormonal remedy Femo-Klim was found to effectively affect the psycho-autonomic status, episodes of cardialgia in women with MHO and estrogen deficiency in MTP. Femo-Klim has a complex versatile effect on the body, makes it possible to safely normalize the level of estrogen, reduces weight, and levels off the clinical manifestations of premenopause. All components of the drug are physiologically close to those of the human body and do not disturb the natural processes in it. Femo-Klim is highly effective with low toxicity, broad-spectrum activity and a complex harmonizing effect on the body.
Keywords: 
therapy
metabolically healthy obesity
psycho-autonomic status
hypersympathicotonia
cardialgia
estrogen deficiency
premenopausal transition period

References: 
  1. Eckel N., Li Y., Kuxhaus O. et al. Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses’ Health Study): 30 year follow-up from a prospective cohort study. Lancet Diabetes Endocrinol. 2018; 6 (9): 714–24. DOI: 10.1016/S2213-8587(18)30137-2.
  2. Schoenaker D.A., Jackson С.А., Rowlands J.V., et al. Socioeconomic position, lifestyle factors and age at natural menopause: a systematicreview and meta-analyses of studies across six continents. Int J Epidemol. 2014; 43: 1542–62. DOI: 10.1093/ije/dyu094
  3. Oganov R.G., Maslennikova G.Y. Demographic trends in the Russian Federation: the impact of cardiovascular disease. Cardiovascular Therapy and Prevention. 2012; 11 (1): 5–10 (in Russ.). DOI: 10.15829/1728-8800-2012-1-5-10
  4. Sims E.A.H. Characterization of the syndromes of obesity. In: Brodoff BN, Bleicher SJ, editors. Diabetes Mellitus and Obesity. Baltimore: Williams and Wilkins; 1982; pp. 219–26.
  5. Rey-Lopez J.P., de Rezende L.F., Pastor-Valero M. et al. The prevalence of metabolically healthy obesity: a systematic review and critical evaluation of the definitions used. Obes Rev. 2014; 15 (10): 781–90. DOI: 10.1111/obr.12198
  6. Khabibulina M.M. Kardiovaskulyarnyi risk pri estrogenodefitsite v doklimaktericheskikh periodakh. Yekaterinburg, 2014 (in Russ.).
  7. Dvoryanskiy S.A., Emelyanova D.I., Yagovkina N.V. Climacteric syndrome: current status of the issue (literature review). Vyatskii med vestn. 2017; 1 (53): 7–15 (in Russ.).
  8. Romantsova T., Ostrovskaya E. Metabolically healthy obesity: definitions, protective factors, clinical relevance. Almanac of clinical medicine. 2015; 1 (1): 75–86 (in Russ.). DOI: 10.18786/2072-0505-2015-1-75-86
  9. Robertson L.L., Aneni E.C., Maziak W., et al. Metabolically healthy obese phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality – a systematic review. BMC Public Health. 2014; 14: 14. DOI: 10.1186/1471-2458-14-14
  10. Biobank Standardisation and Harmonisation for Research Excellence in the European Union From 2010-12-01 to 2015-11-30, project 261433.
  11. Muñoz-Garach A., Cornejo-Pareja I., Tinahones F.J. Does Metabolically Healthy Obesity Exist? Nutrients. 2016; 8 (6): pii: E320. DOI: 10.3390/nu8060320
  12. Smetnik V.P. Rukovodstvo po klimakcu. Rukovodstvo dlya vrachei. Pod red. V.I. Kulakova, V.P. Smetnik. M.: Meditsinskoe informatsionnoe agentstvo, 2001; 685 s. (in Russ.).
  13. Smetnik V.P. Lechenie klimaktericheskikh rasstroistv. Meditsinskii sovet. 2007; 4: 38–43 (in Russ.).
  14. Khabibulina M. Hemodynamic parameters in women with hypoestrogenemia with metabolically healthy obesity. Vrach. 2018; 29 (1): 34–7 (in Russ.). DOI: 10.29296/25877305-2018-01-09
  15. Khabibulina M. The vascular bed in estrogen deficiency with hypertension and obesity. Vrach. 2018; 29 (2): 65–8 (in Russ.). DOI: 10.29296/25877305-2018-02-16
  16. Khabibulina M.M. Izmenenie sostoyaniya sosudistogo rusla u molodykh zhenshchin s estrogenodefitsitom, dislipidemiei i arterial’noi gipertenziei pod vliyaniem mertenila. Farmateka. 2014; 6: 12–8 (in Russ.).
  17. Khabibulina MM. Mertenil’s influence on the state of the vascular bed in women with arterial hypertension and dyslipidemia in case of hypoestrogenemy at premenopausal period. Kardiologiya i Serdechno-Sosudistaya Khirurgiya. 2013; 6 (6): 43–7 (in Russ.).
  18. Khabibulina M.M., Dmitriev A.N., Fedorova N.N. Kachestvo zhizni molodykh zhenshchin s arterial’noi gipertenziei s gipoestrogenemiei s «metabolicheski zdorovym» vistseral’nym ozhireniem. Evraziiskii Soyuz Uchenykh. 2017; 1 (34): 25–9 (in Russ.).
  19. Khabibulina M. Dysrhythmias in hypoestrogenemia with metabolically healthy obesity. Vrach. 2017; 9: 55–8 (in Russ.).
  20. Khabibulina M.M. Narusheniya ritma i provodimosti u zhenshchin s gipertonicheskoi bolezn’yu v period premenopauzy v zavisimosti ot funktsii endoteliya perifericheskikh arterii. Ural’skii meditsinskii zhurnal. 2008; 2 (42): 28–31 (in Russ.).
  21. Khabibulina M.M., Smolentseva A.A. Terapiya trevozhnykh rasstroistv u zhenshchin s arterial’noi gipertenziei v period premenopauzy na ambulatornom etape. V sb.: V s»ezd kardiologov Ural’skogo federal’nogo okruga. Mat-ly s»ezda. 2011; s. 282–4 (in Russ.).
  22. Gromova O.A., Torshin I.Yu., Limanov O.A. et al. Patofiziologiya vegetativno-sosudistykh paroksizmov (prilivy) v period menopauzy u zhenshchin i mekhanizmy vozdeistviya beta-alanina. Novaya kliniko-farmakologicheskaya kontseptsiya. Ginekologiya. 2010; 12 (2): 29–36 (in Russ.).
  23. Zarochentseva N.V., Dzhidzhikhiia L.K. Possibilities of using klimalanin in menopausal women with vasomotor paroxysms. Russian Bulletin of Obstetrician-Gynecologist = Rossiyskiy vestnik akushera-ginekologa. 2012; 12 (3): 92–7 (in Russ.).
  24. Ilovaiskaya I.A., Voitashevskii K.V. Menopauzal’naya gormonal’naya terapiya: vozmozhnosti i riski. Status Praesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2015; 5 (28): 80–6 (in Russ).
  25. Menopauzal’naya gormonal’naya terapiya i sokhranenie zdorov’ya zhenshchin zrelogo vozrasta: Klinicheskie rekomendatsii (protokol lecheniya). M.: FGBU NTsGAiP, 2015 (in Russ).
  26. Sturdee D.W., Pines A. Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health Group. Climacteric. 2011; 14: 302–20. DOI: 10.3109/13697137.2011.570590
  27. Khabibulina M.M., Dmitriev A.N. Sposob optimizatsii lecheniya zhenshchin kardiotropnoi terapiei i zamestitel’noi gormonal’noi terapiei pri estrogenodefitsite s arterial’noi gipertenziei v pozdnem reproduktivnom periode. Patent na izobretenie RU 2648470 C2, 26.03.2018 Zayavka №2016107890 ot 03.03.2016 (in Russ.).
  28. Khabibulina M. Therapy in women with hypertension and estrogen deficiency in the late fertile period. Vrach. 2016; 4: 45–9 (in Russ.).
  29. Sychev O.S. Ambulatornoe kholterovskoe monitorirovanie EKG. Ukr kardiol zhurn. 2005; 5: 11–36 (in Russ.).
  30. Ovsyannikova T.V., Makarov I.O., Kulikov I.A. Clinical efficacy of non-hormonal methods of therapy in perimenopausal women. Obstetrics, Gynecology and Reproduction. 2013; 7 (3): 26–9 (in Russ.).
  31. Petrova E., Kalistratov V., Polyboyarinov P. et al. The menopause drug Femo-Klim is the best nonhormonal solution of hormonal problems. Vrach. 2019; 30 (1): 46–9 (in Russ.). DOI: 10.29296/25877305-2019-01-08
  32. Radzinskii V.E., Dobretsova T.A. Menopauza kak mekhanizm zhenskogo stareniya. Fitoestrogeny – razvedka boem. StatusPraesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2015; 2 (25): 51–8 (in Russ.).
  33. Radzinskii V.E., Dobretsova T.A., Ryzhova T.E. Biologicheskaya rol’ menopauzal’nogo perekhoda i terapevticheskie vozmozhnosti fitoestrogenov. StatusPraesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2015; 4 (27): 77–82 (in Russ.).
  34. Tatarova N.A., Linde V.A., Zhidkova E.V. et al. Negormonal’naya korrektsiya klimaktericheskikh rasstroistv v peri- i postmenopauze. Effektivnaya farmakoterapiya v akusherstve i ginekologii. 2009; 17: 12–5 (in Russ.).
  35. Khamoshina M.B., Rogovskaya S.I., Naumchik G.A. Aktual’nye vozmozhnosti farmakologii v profilaktike vozrastnykh narushenii. StatusPraesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2014; 1 (18): 75–81