Benign forgetfulness and dementia in old age groups


Professor A. Volobuev, Biol.D; P. Romanchuk, Candidate of Medical Sciences;
N. Romanchuk, Candidate of Medical Sciences; Professor S. Krasnov, Biol. D; Professor I. Davydkin, MD
Samara State Medical University

The paper considers the molecular mechanisms of emergence of short-term and long-term memory in the human cerebral cortex. It shows that short-term memory is due to an increase in the function of synaptic connections in the cerebral cortex, while long-term memory is due to the emergence of additional duplicate synaptic connections. Forgetting and remembering various concepts occurs due to the disruption and subsequent restoration of synaptic connections in the cyclic neuronal circuits of the neocortex. The principles of drug exposure in the development of dementia are assessed

senile dementia
entorhinal cortex
synaptic connection
cyclic neuronal circuit.

  1. Kas’yanov E., Filippov D. Vskrytie mozga: neirobiologiya psikhicheskikh rasstroistv. M.: AST, 2020; 224 s. (in Russ.).
  2. Kandel ER. In Search of Memory. The Emergence of a New Science of Mind. Transl. from engl. M.: AST; CORPUS, 2021; 736 s. (in Russ.).
  3. Hubel D., Stevens C., Kandel E. et al The Brain. Transl. from engl. M.: Mir, 1987 (in Russ.).
  4. Sandler R.A., Dong Song, Hampson R.E. et al. Hippocampal closed-loop modeling and implications for seizure simulation design. J Neural Eng. 2015; 12 (5): 056017. DOI: 10.1088/1741-2560/12/5/056017
  5. Bredesen D.E. The End of Alzheimer’s. The First Program to Prevent and Reverse Cognitive Decline. Transl. from engl. M.: EKSMO, 2019; 304 s. (in Russ.).