Microcirculatory bed changes induced by viper, cobra, and bee venoms

DOI: https://doi.org/10.29296/25877305-2022-03-03
Issue: 
3
Year: 
2022

Associate Professor V. Kutsenko(1), Candidate of Medical Sciences; D. Kovaleva(1); E.
Peresada(2); Associate Professor P. Seliverstov(3, 4), Candidate of Medical Sciences (1)Saint Petersburg
Pediatric University Ministry of Health of the Russia (2)AO «North-Western Center of Evidence-based
Medicine», Saint Petersburg (3)I.I. Mechnikov North-Western State Medical University Ministry of Health of
the Russia, Saint Petersburg (4)V.A. Almazov National Medical Research Center Ministry of Health of the
Russia, Saint Petersburg

The microcirculatory bed (MCB) can individually respond to both a chemical agent and venom. This feature can be used in the diagnosis of poisonings and in the intake of drugs containing cytotoxins and neurotoxins.
Keywords: 
microcirculatory bed
topical preparations
venom
diagnostics
capillaroscopy

References: 
  1. Andreeva T.A., Zorenko V.Ju., Davydkin I.L. i dr. Effektivnost' i bezopasnost' preparata Oktofaktor v lechenii bol'nyh s tjazheloj i srednetjazheloj formoj gemofilii A (rezul'taty 2-j chasti klinicheskogo issledovanija II i III fazy). Voprosy gematologii/onkologii i immunopatologii v pediatrii. 2013; 12 (4): 31–7.
  2. Ahmineeva A.H., Polunina O.S. Disfunktsija endotelija pri hronicheskoj obstruktivnoj bolezni legkih i bronhial'noj astme. Astrahanskij meditsinskij zhurnal. 2012; 7 (3): 43–6.
  3. Belotserkovtseva L.D., Kovalenko L.V., Korneeva E.V. i dr. Disfunktsija endotelija kak prediktor razvitija metabolicheskogo sindroma u zhenschin v period menopauzy. Vestnik novyh meditsinskih tehnologij. 2010; 17 (1): 91–3.
  4. Boeva N.A., Medvedeva V.N. Disfunktsija endotelija pri abdominal'nym ozhirenii v molodom i srednem vozraste. Vestnik Ivanovskoj meditsinskoj akademii. 2009; 14: 43.
  5. Brodskaja T.A., Nevzorova V.A., Gel'tser B.I. i dr. Endotelial'naja disfunktsija i bolezni organov dyhanija. Ter arh. 2007; 79 (3): 76–84.
  6. Volkov A.V., Mach E.S., Guseva N.G. Disfunktsija endotelija pri sistemnoj sklerodermii – kliniko-patogeneticheskie korreljatsii. Ter arh. 2008; 80 (10): 68–71.
  7. Vorob'ev E.N., Shumaher G.I., Horeva M.A. i dr. Disfunktsija endotelija – kljuchevoe zveno v patogeneze ateroskleroza. Rossijskij kardiologicheskij zhurnal. 2010; 2: 84–91.
  8. Galitsin P.V., Litvin A.Ju., Chazova I.E. Sindrom obstruktivnogo apnoe sna i disfunktsija endotelija. Kardiologicheskij vestnik. 2007; 2 (1): 53–60.
  9. Ganuzin V.M. Klassifikatsija, klinicheskie simptomy i neotlozhnaja meditsinskaja pomosch' na dogospital'nom etape pri ukuse jadovityh zmej. Prakticheskaja meditsina. 2021; 19 (2): 39–42.
  10. Grigor'eva V.E., Gunar O.V., Sahno N.G. i dr. Lekarstvennye sredstva, soderzhaschie zmeinyj jad: istorija razvitija, nomenklatura, otsenka podlinnosti. Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo primenenija. 2018; 8 (2): 77–83. DOI: 10.30895/1991-2919-2018-8-2-77-83
  11. Zajtseva O.V., Malenev A.L., Bakiev A.G. Issledovanija svojstv jada obyknovennoj gadjuki v Volzhskom bassejne: prakticheskoe znachenie poluchennyh rezul'tatov. Samarskaja Luka: problemy regional'noj i global'noj ekologii. 2011; 20 (1): 180–4.
  12. Zakirova N.E., Oganov R.G., Zakirova A.N. i dr. Disfunktsija endotelija pri ishemicheskoj bolezni serdtsa. Ratsional'naja farmakoterapija v kardiologii. 2008; 4 (4): 23–7. DOI: 10.20996/1819-6446-2008-4-4-23-27
  13. Zorenko V.Ju., Mishin G.V., Severova T.V. i dr. Farmakokineticheskie svojstva, bezopasnost' i perenosimost' preparata Oktofaktor (rezul'taty I fazy klinicheskogo issledovanija u bol'nyh gemofiliej A). Voprosy gematologii/onkologii i immunopatologii v pediatrii. 2013; 12 (2): 30–7.
  14. Ivnitskij Ju.Ju., Rejnjuk V.L., Ivanov M.B. i dr. Sosudistyj endotelij pri ostryh otravlenijah. Medline.ru. Rossijskij biomeditsinskij zhurnal. 2020; 21: 976–1004.
  15. Kiseleva N.I. Disfunktsija endotelija pri gestoze: patogenez, dinamika i lechenie. Ohrana materinstva i detstva. 2006; 1 (7): 49–56.
  16. Kuznik B.I., Sturov V.G., Levshin N.Ju., i dr. Gemorragicheskie i tromboticheskie zabolevanija i sindromy u detej i podrostkov: Patogenez, klinika, diagnostika, terapija i profilaktika. Novosibirsk: Nauka, 2018; 524 s.
  17. Kutsenko V.P., Kovaleva D.D., Peresada E.I. i dr. Okazanie meditsinskoj pomoschi pri ukuse jadovitoj zmei. Meditsinskaja sestra. 2022; 24 (1): 26–35. DOI: 10.29296/25879979-2022-01-04
  18. Matsjuk T.V. Osobennosti klinicheskogo techenija hronicheskoj gastroduodenal'noj patologii u detej s NO-zavisimoj disfunktsiej endotelija. Zhurnal GrGMU. 2007; 3 (19): 51–4.
  19. Mihno V.A., Nikitina I.L. Disfunktsija endotelija kak faktor riska saharnogo diabeta i serdechno-sosudistoj patologii. Zabajkal'skij meditsinskij vestnik. 2009; 15: 92–7.
  20. Morrison V.V., Bozhedomov A.Ju. Disfunktsija endotelija pri sindrome poliorgannoj nedostatochnosti u bol'nyh s termicheskoj travmoj. Regionarnoe krovoobraschenie i mikrotsirkuljatsija. 2013; 12 (2): 43–8. DOI: 10.24884/1682-6655-2013-12-2-43-48
  21. Naumov A.V., Vyshivanjuk V.A., Vertkin A.P. Disfunktsija endotelija sosudov i gemodinamicheskie narushenija v paradonte u molodyh ljudej s nikotinovoj zavisimost'ju. Kardiologicheskaja terapija i profilaktika. 2012; 11 (2): 70–5. DOI: 10.15829/1728-8800-2012-2-70-75
  22. Nebylitsin Ju.S., Sushkov S.A., Solodkov A.P. i dr. Disfunktsija endotelija pri ostroj i hronicheskoj venoznoj nedostatochnosti. Novosti hirurgii. 2008; 16 (14): 141–53.
  23. Seidova G.B. Disfunktsija endotelija i razvitie IBS u zhenschin v pre- i postmenopauze. Regionarnoe krovoobraschenie i mikrotsirkuljatsija. 2005; 4 (1): 46–52.
  24. Skol'skaja O.Ju., Tarasova L.N., Vladimirova S.G. i dr. Disfunktsija endotelija i narushenie gemostaza v debjute ostrogo limfoblastnogo lejkoza u vzroslyh bol'nyh. Gematologija i transfuziologija. 2013; 58 (1): 28–31.
  25. Stojko Ju.M., Gudymovich V.G., Trifonov S.I. i dr. Disfunktsija endotelija u bol'nyh hronicheskoj venoznoj nedostatochnost'ju nizhnih konechnostej i vozmozhnosti ee korrektsii. Novosti hirurgii. 2010; 18 (4): 57–64.
  26. Homutov A.E., Pursanov V.A., Lushnikova O.V. i dr. Apitoksinoterapija. Monografija. Nizhnij Novgorod: Izd-vo NNGU. 2015; 456 s.
  27. Shishkin A.N., Kiriljuk D.V. Disfunktsija endotelija u patsientov s progressirujuschimi zabolevanijami pochek. Nefrologija. 2005; 9 (2): 16–22. DOI: 10.24884/1561-6274-2005-9-2-16-22
  28. Ellenhorn M.Dzh. Meditsinskaja toksikologija: Diagnostika i lechenie otravlenij u cheloveka: V 2 t. T.2: Per. s angl. M.: Meditsina, 2003; 1048 s. Ellenhorn M.J. Medical Toxicology. V 2 t. T.2: Tranl. engl. M.: Meditsina, 2003; 1048 p. (in Russ.).
  29. Andreeva T.A., Zorenko V.Yu., Davydkin I.L. et al. Efficiency and safety of octofactor in the treatment of patients with severe and moderate hemophilia A: results of part 2 of phase II–III clinical trial. Pediatric Hematology/Oncology and Immunopathology. 2013; 12 (4): 31–7 (in Russ.).
  30. Ahmineeva A.H., Polunina O.S. The dysfunction of endothelium in chronic obstructive pulmonary disease and bronchial asthma. Astrakhanskii meditsinskii zhurnal. 2012; 7 (3): 43–6 (in Russ.).
  31. Belotserkovtseva L.D., Kovalenko L.V., Korneyev E.V. et al. Disfunction of endothelium as the predictor of the development of metabolic syndrome in women in the period of perimenopause. Vestnik novykh meditsinskikh tekhnologii. 2010; 17 (1): 91–3 (in Russ.).
  32. Boeva N.A., Medvedeva V.N. Disfunktsiya endoteliya pri abdominal’nym ozhirenii v molodom i srednem vozraste. Vestnik Ivanovskoi meditsinskoi akademii. 2009; 14: 43 (in Russ.).
  33. Brodskaya T.A., Nevzorova V.A., Geltser B.I. et al. Endothelial dysfunction and respiratory diseases. Ter arkh. 2007; 79 (3): 76–84 (in Russ.).
  34. Volkov A.V., Mach E.S., Guseva N.G. Endothelial dysfunction in systemic sclerosis – clinicopathogenetic correlations. Ter arkh. 2008; 80 (10): 68–71 (in Russ.).
  35. Vorobyeva E.N., Shumakher G.I., Khoreva M.A. et al. Endothelial dysfunction – a key factor in atherosclerosis pathogenesis. Russian Journal of Cardiology. 2010; 2: 84–91 (in Russ.).
  36. Galitsin P.V., Litvin A.Yu., Chazova I.E. Sindrom obstruktivnogo apnoe sna i disfunktsiya endoteliya. Kardiologicheskii vestnik. 2007; 2 (1): 53–60 (in Russ.).
  37. Ganuzin V.M. Classification, clinical symptoms and emergency medical aid at the pre-hospital stage for venomous snake bites. Practical medicine. 2021; 19 (2): 39–42 (in Russ.).
  38. Grigorieva V.E., Gunar O.V., Sakhno N.G. et al. Drugs containing snake venom: history of development, nomenclature, identification. The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products. 2018; 8 (2): 77–83 (in Russ.). DOI: 10.30895/1991-2919-2018-8-2-77-83
  39. Zaitseva O.V., Malenev A.L., Bakiev A.G. Issledovaniya svoistv yada obyknovennoi gadyuki v Volzhskom basseine: prakticheskoe znachenie poluchennykh rezul’tatov. Samarskaya Luka: problemy regional’noi i global’noi ekologii. 2011; 20 (1): 180–4 (in Russ.).
  40. Zakirova N.E., Oganov R.G., Zakirova A.N. et al. Endothelial dysfunction in ischemic heart disease. Rational Pharmacotherapy in Cardiology. 2008; 4 (4): 23–7. (in Russ.). DOI: 10.20996/1819-6446-2008-4-4-23-27
  41. Zorenko V.Yu., Mishin G.V., Severova T.V. et al. Pharmacokinetics, safety, and tolerability of octofactor in patients with hemophilia A: results of phase I clinical study. Pediatric Hematology/Oncology and Immunopathology. 2013; 12 (2): 30–7 (in Russ.).
  42. Ivnitsky J.J., Rejniuk V.L., Ivanov M.B. et al. Vascular endothelium in acute poisonings. Medline.ru. Rossiiskii biomeditsinskii zhurnal. 2020; 21: 976–100 (in Russ.).
  43. Kiseleva N.I. Disfunktsiya endoteliya pri gestoze: patogenez, dinamika i lechenie. Okhrana materinstva i detstva. 2006; 1 (7): 49–56 (in Russ.).
  44. Kuznik B.I., Sturov V.G., Levshin N.Yu., i dr. Gemorragicheskie i tromboticheskie zabolevaniya i sindromy u detei i podrostkov: Patogenez, klinika, diagnostika, terapiya i profilaktika. Novosibirsk: Nauka, 2018; 524 s. (in Russ.).
  45. Kutsenko V.P., Kovaleva D.D., Peresada E.I. et al. Providing medical attention for a poisonous snake bite. Meditsinskaya sestra = The Nurse. 2022; 24 (1): 26–35. DOI: 10.29296/25879979-2022-04
  46. Matsyuk T.V. Peculiarities of clinical course of chronic gastroduodenal pathology in children with no-dependent dysfunction of endothelium. Journal GrSMU. 2007; 3 (19): 51–4 (in Russ.).
  47. Mikhno V.A., Nikitina I.L. Endotelial disfunction as a risk factor of diabetes mellitus and cardiovascular pathology. Zabaikalskii Med Vestnik = Medical Bulleten of Zabaykal Region. 2009; 1: 53–64 (in Russ.).
  48. Morrison V.V., Bozhedomov A.J. Dysfunction of endothelium at multiorgan failure syndrome by burn patients. Regional blood circulation and microcirculation. 2013; 12 (2): 43–8. (in Russ.). DOI: 10.24884/1682-6655-2013-12-2-43-48 Naumov A.V., Vyshivanyuk V.A., Vertkin A.L. Endothelial dysfunction and periodontal hemodynamic disturbances in young patients with nicotine dependence. Cardiovascular Therapy and Prevention. 2012; 11 (2): 70–5 (in Russ.). DOI: 10.15829/1728-8800-2012-2-70-75
  49. Nebylitsin Yu.S., Sushkov S.A., Solodkov A.P. et al. Disfunktsiya endoteliya pri ostroi i khronicheskoi venoznoi nedostatochnosti. Novosti khirurgii. 2008; 16 (14): 141–53 (in Russ.).
  50. Seidova G.B. Disfunktsiya endoteliya i razvitie IBS u zhenshchin v pre- i postmenopauze. Regional blood circulation and microcirculation. 2005; 4 (1): 46–52 (in Russ.).
  51. Skolskaya O.Yu., Tarasova L.N., Vladimirova S.G. et al. Endothelial dysfunction and hemostatic disorders in adult patients with acute lymphoblastic leukemia de novo. Russian journal of hematology and transfusiology. 2013; 58 (1): 28–31 (in Russ.).
  52. Stoiko Yu.M., Gudymovich V.G., Trifonov S.I. et al. Disfunktsiya endoteliya u bol’nykh khronicheskoi venoznoi nedostatochnost’yu nizhnikh konechnostei i vozmozhnosti ee korrektsii. Novosti khirurgii. 2010; 18 (4): 57–64 (in Russ.).
  53. Khomutov A.E., Pursanov V.A., Lushnikova O.V. et al. Apitoksinoterapiya. Monografiya. Nizhnii Novgorod: Izd-vo NNGU. 2015; 456 p. (in Russ.).
  54. Shishkin A.N., Kirilyuk D.V. Endothelial dysfunction in patients with progressive renal disease. Nephrology (Saint-Petersburg). 2005; 9 (2): 16–22 (in Russ.). DOI: 10.24884/1561-6274-2005-9-2-16-22
  55. Ellenhorn M.J. Medical Toxicology. V 2 t. T.2: Tranls. from Engl. M.: Meditsina, 2003; 1048 p. (in Russ.).