INTERRELATION OF HAIR ELEMENTS’ CONTENT WITH CO-OCCURRING SOMATIC CONDITIONS IN CHILDREN WITH AUTISM SPECTRUM DISORDER
DOI: https://doi.org/10.29296/25877305-2021-11-12
Issue:
11
Year:
2021
Autism Spectrum Disorder (ASD) is a heterogenous group of neurodevelopmental disorders associated
with distinct somatic comorbidities. The core symptoms of ASD in children are often aggravated by
co-occurring conditions and require the awareness of pediatricians and other specialists. Imbalance of
elements are currently considered as one of the possible etiopathogenetic factors of ASD and comorbid
conditions. Elements plays crucial role in the formation and development of the child body. They act as
cofactors of a number of enzymes, providing the functioning of various metabolic pathways. The study
analyzed the structure of somatic symptoms in 62 children (45 boys, 17 girls) 1–13 years old with ASD (F.84)
confirmed by a psychiatrist and compared it with hair elements’ levels. Correlation analysis using
nonparametric methods was used to study the relationship between the hair elements’ content and various
somatic conditions in children with ASD. Thus, musculoskeletal diseases correlated with the hair level of
potassium (r=-0.284; p=0.05), calcium (r=0.251; p=0.05) and copper (r=0.281; p=0.05), cardiovascular
diseases correlated with the hair level of sodium (r=-0.260; p=0.05), pathology of respiratory tract
correlated with the hair level of selenium (r=0.295; p=0.05), genitourinary diseases correlated with the
hair level of iodine (r=0.375; p=0.01) and silicon (r=0.265; p=0.05), endocrine pathology correlated with
the hair level of calcium (r=0.309; p=0.05) and zinc (r=0.270; p=0.05), immunopathology correlated with the
hair level of vanadium (r=0.252; p=0.05), and allergic pathology correlated with the hair level of nickel
(r=0.346; p=0.01) and aluminum (r=0.251; p=0.05). The revealed correlations between the hair elements’
content and various somatic conditions confirm the effect of elemental metabolism on health status of
children with ASD.
Keywords:
autism
macro elements
trace elements
neurodevelopment
comorbidity
co-occurring conditions
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