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L. Chernova, A. Skalny I.M. Sechenov First Moscow State Medical University (Sechenov
University), Ministry of Health of Russia

Autism Spectrum Disorder (ASD) is a heterogenous group of neurodevelopmental disorders associated with distinct somatic comorbidities. The core symptoms of ASD in children are often aggravated by co-occurring conditions and require the awareness of pediatricians and other specialists. Imbalance of elements are currently considered as one of the possible etiopathogenetic factors of ASD and comorbid conditions. Elements plays crucial role in the formation and development of the child body. They act as cofactors of a number of enzymes, providing the functioning of various metabolic pathways. The study analyzed the structure of somatic symptoms in 62 children (45 boys, 17 girls) 1–13 years old with ASD (F.84) confirmed by a psychiatrist and compared it with hair elements’ levels. Correlation analysis using nonparametric methods was used to study the relationship between the hair elements’ content and various somatic conditions in children with ASD. Thus, musculoskeletal diseases correlated with the hair level of potassium (r=-0.284; p=0.05), calcium (r=0.251; p=0.05) and copper (r=0.281; p=0.05), cardiovascular diseases correlated with the hair level of sodium (r=-0.260; p=0.05), pathology of respiratory tract correlated with the hair level of selenium (r=0.295; p=0.05), genitourinary diseases correlated with the hair level of iodine (r=0.375; p=0.01) and silicon (r=0.265; p=0.05), endocrine pathology correlated with the hair level of calcium (r=0.309; p=0.05) and zinc (r=0.270; p=0.05), immunopathology correlated with the hair level of vanadium (r=0.252; p=0.05), and allergic pathology correlated with the hair level of nickel (r=0.346; p=0.01) and aluminum (r=0.251; p=0.05). The revealed correlations between the hair elements’ content and various somatic conditions confirm the effect of elemental metabolism on health status of children with ASD.

macro elements
trace elements
co-occurring conditions

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