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Molecular markers for injury to the dentofacial system in children with chronic kidney disease

DOI: https://doi.org/10.29296/25877305-2021-11-11

N. Morozova, Candidate of Medical Sciences(1); Professor A. Mamedov(1), MD; D. Lakomova(2),
Candidate of Medical Sciences; Professor N. Zakharova(2), MD; L. Maltseva(1), Candidate of Medical Sciences;
E. Maslikova(1); A. Elovskaya(1); Professor O. Morozova(1), MD (1)I.M. Sechenov First Moscow State Medical
University (Sechenov University), Ministry of Health of Russia (2)V.I. Razumosky Saratov State Medical
University, Ministry of Health of Russia

Chronic kidney disease CKD) is a lesion of the organ, which is based on the replacement of the parenchyma by scar tissue with a progressive decline in its function. Uremic toxins lead to injury to the dentofacial system (DFS). Objective: to analyze the patterns of changes in salivary biomarkers in children with CKD. Subjects and methods. Examinations were made in 76 children, including 19 healthy individuals and 57 patients with DFS abnormalities in the presence of CKD. The patients were divided into groups: 1) 19 children with congenital urinary tract anomalies, acquired kidney disease, and Stage 1–2 CKD, who took medications; 2) 19 children with end-stage CKD, who received renal replacement therapy as hemodialysis; 3) 19 children after kidney transplantation; 4) 19 practically healthy children without kidney disease, who were stratified by gender and age (a control group). All the children underwent a standard set of dental examination, including determination of the level of salivary biomarkers of angiogenesis (VEGF-A) and fibrogenesis (TGF-β1). Results. Group 1 children were found to have a carious pathology in the oral cavity; Groups 2 and 3 had noninflammatory and atrophic changes in soft tissues and osteodystrophic damage to hard dental tissues. The study of salivary VEGF-A could establish a significantly reduced level of this marker in children with end-stage CKD. Conclusion. There was an association between the severity and clinical forms of DFS pathology in the presence of CKD and the nature of salivary changes in angio- and fibrogenesis.

chronic kidney disease
salivary biomarkers

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