Molecular markers for injury to the dentofacial system in children with chronic kidney disease

Download full text PDF

N. Morozova, Candidate of Medical Sciences(1); Professor A. Mamedov(1), MD; D. Lakomova(2),
Candidate of Medical Sciences; Professor N. Zakharova(2), MD; L. Maltseva(1), Candidate of Medical Sciences;
E. Maslikova(1); A. Elovskaya(1); Professor O. Morozova(1), MD (1)I.M. Sechenov First Moscow State Medical
University (Sechenov University), Ministry of Health of Russia (2)V.I. Razumosky Saratov State Medical
University, Ministry of Health of Russia

Chronic kidney disease CKD) is a lesion of the organ, which is based on the replacement of the parenchyma by scar tissue with a progressive decline in its function. Uremic toxins lead to injury to the dentofacial system (DFS). Objective: to analyze the patterns of changes in salivary biomarkers in children with CKD. Subjects and methods. Examinations were made in 76 children, including 19 healthy individuals and 57 patients with DFS abnormalities in the presence of CKD. The patients were divided into groups: 1) 19 children with congenital urinary tract anomalies, acquired kidney disease, and Stage 1–2 CKD, who took medications; 2) 19 children with end-stage CKD, who received renal replacement therapy as hemodialysis; 3) 19 children after kidney transplantation; 4) 19 practically healthy children without kidney disease, who were stratified by gender and age (a control group). All the children underwent a standard set of dental examination, including determination of the level of salivary biomarkers of angiogenesis (VEGF-A) and fibrogenesis (TGF-β1). Results. Group 1 children were found to have a carious pathology in the oral cavity; Groups 2 and 3 had noninflammatory and atrophic changes in soft tissues and osteodystrophic damage to hard dental tissues. The study of salivary VEGF-A could establish a significantly reduced level of this marker in children with end-stage CKD. Conclusion. There was an association between the severity and clinical forms of DFS pathology in the presence of CKD and the nature of salivary changes in angio- and fibrogenesis.

chronic kidney disease
salivary biomarkers

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

  1. Raubenheimer E.J., Noffke C.E., Hendrik H.D. Chronic kidney disease-mineral bone disorder: an update on the pathology and cranial manifestations. J Oral Pathol Med. 2015; 44 (4): 239–43. DOI: 10.1111/jop.12176
  2. Murugapoopathy V., McCusker C., Gupta I.R. The pathogenesis and management of renal scarring in children with vesicoureteric reflux and pyelonephritis. Pediatr Nephrol. 2020; 35 (3): 349–57. DOI: 10.1007/s00467-018-4187-9
  3. Mizutani K., Mikami R., Gohda T. et al. Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: a 3-year cohort study. Sci Rep. 2020; 10 (1): 21872. DOI:10.1038/s41598-020-78724-1
  4. Oduncuoğlu B.F., Alaaddinoğlu E.E., Çolak T. et al. Effects of Renal Transplantation and Hemodialysis on Patient’s General Health Perception and Oral Health-Related Quality of Life: A Single-Center Cross-Sectional Study. Transplant Proc. 2020; 52 (3): 785–92. DOI: 10.1016/j.transproceed.2020.01.016
  5. Kovalčiková A.G., Pavlov K., Lipták R. et al. Dynamics of salivary markers of kidney functions in acute and chronic kidney diseases. Sci Rep. 2020; 10 (1): 21260. DOI: 10.1038/s41598-020-78209-1
  6. Bover J., Molina P., Ureña-Torres P. et al. Feasible Low-Phosphorus Dietary Patterns in Maintenance Hemodialysis Patients: Need for Original Research. Kidney Int Rep. 2020; 5 (11): 1845–7. DOI: 10.1016/j.ekir.2020.09.008
  7. Schmalz G., Patschan S., Patschan D. et al. Oral health-related quality of life in adult patients with end-stage kidney diseases undergoing renal replacement therapy – a systematic review. BMC Nephrol. 2020; 21 (1): 154. DOI: 10.1186/s12882-020-01824-7
  8. Yamada S., Inaba M. Potassium Metabolism and Management in Patients with CKD. Nutrients. 2021; 13 (6): 1751. DOI: 10.3390/nu13061751
  9. Limeira F.I.R., Yamauti M., Moreira A.N. et al. Dental caries and developmental defects of enamel in individuals with chronic kidney disease: Systematic review and meta-analysis. Oral Dis. 2019; 25 (6): 1446–64. DOI: 10.1111/odi.12993
  10. Liu W.C., Wu C.C., Lim P.S. et al. Effect of uremic toxin-indoxyl sulfate on the skeletal system. Clin Chim Acta. 2018; 484: 197–206. DOI: 10.1016/j.cca.2018.05.057
  11. Krajewska Wojciechowska J., Krajewski W., Zatoński T. Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages. Eur Arch Otorhinolaryngol. 2020; 277 (6): 1575–91. DOI: 10.1007/s00405-020-05925-9
  12. Da Costa T.A., Silva M.J., Alves P.M. et al. Inflammation Biomarkers of Advanced Disease in Nongingival Tissues of Chronic Periodontitis Patients. Mediators Inflamm. 2015; 2015: 983782. DOI: 10.1155/2015/983782
  13. Melguizo-Rodriguez L., Costela-Ruiz V.J., Manzano-Moreno F.J. et al. Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies. Int J Mol Sci. 2020; 21 (14): 5173. DOI: 10.3390/ijms21145173
  14. Morozova O.L., Mal'tseva L.D., Makarova V.D. VEGF – marker gipoksii pri povrezhdenii pochek razlichnogo geneza. Patogenez. 2018; 16 (2): 62–9 [Morozova O.L., Maltseva L.D., Makarova V.D. VEGF as a biomarker for hypoxia in kidney injury ofdifferent origins. Patogenez = Pathogenesis. 2018; 16 (2): 62–9 (in Russ.)]. DOI: 10.25557/2310-0435.2018.02.62-69
  15. Sastim Y.S., Gürsoy M., Könönen E. et al. Salivary and serum markers of angiogenesis in periodontitis in relation to smoking. Clin Oral Investig. 2021; 25 (3): 1117–26. DOI: 10.1007/s00784-020-03411-4
  16. Nishio K., Ozawa Y., Ito H. et al. Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7. J Recept Signal Transduct Res. 2017; 37 (5): 515–21. DOI: 10.1080/10799893.2017.1360352
  17. González C.R., Amer M.A., Vitullo A.D. et al. Immunolocalization of the TGFB1 system in submandibular gland fibrosis after experimental periodontitis in rats. Acta Odontol Latinoam. 2016; 29 (2): 138–43.
  18. Seydanur Dengizek E., Serkan D., Abubekir E. et al. Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial. J Appl Oral Sci. 2019; 27: e20180108. DOI: 10.1590/1678-7757-2018-0108
  19. Bernardi L., Santos C.H.M.D., Pinheiro V.A.Z. et al. Transplantation of adipose-derived mesenchymal stem cells in refractory crohn’s disease: systematic review. Arq Bras Cir Dig. 2019; 32 (4): e1465. DOI: 10.1590/0102-672020190001e1465
  20. Valdenegro M., Huidobro C., Monsalve L. et al. Effects of ethrel, 1-MCP and modified atmosphere packaging on the quality of ‘Wonderful’ pomegranates during cold storage. J Sci Food Agric. 2018; 98 (13): 4854–65. DOI: 10.1002/jsfa.9015
  21. Mohapatra A., Valson A.T., Gopal B. et al. Hemostatic abnormalities in severe renal failure: do they bark or bite? Indian J Nephrol. 2018; 28 (2): 135–42. DOI: 10.4103/ijn.IJN_104_17
  22. Coban M., Inci A. The association of serum angiogenic growth factors with renal structure and function in patients with adult autosomal dominant polycystic kidney disease. Int Urol Nephrol. 2018; 50 (7): 1293–300. DOI: 10.1007/s11255-018-1866-1
  23. Pakosch D., Papadimas D., Munding J. et al. Osteonecrosis of the mandible due to anti-angiogenic agent, bevacizumab. Oral Maxillofac Surg. 2013; 17 (4): 303–6. DOI: 10.1007/s10006-012-0379-9