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TARGETED THERAPY FOR SYSTEMIC LUPUS ERYTHEMATOSUS: PRESENT AND FUTURE

DOI: https://doi.org/10.29296/25877305-2021-11-03
Issue: 
11
Year: 
2021

N. Kunitskaya, MD, PhD I.I. Mechnikov North-Western State Medical University, Ministry of
Health of Russia, Saint Petersburg

Systemic lupus erythematosus (SLE) is an autoimmune systemic disease, the pathogenesis of which is based on defects in immunoregulation, leading to uncontrolled hyperproduction of autoantibodies to the components of their own tissues and the development of chronic inflammation affecting many organs and systems. The close interest in SLE over the past decades has allowed us to improve the methods of diagnosing the disease, but the management of patients continues to be a difficult task. The development of treatment methods is hampered primarily by the unknown etiology of the disease, the large variability of clinical manifestations, the possibility of both long-term spontaneous remissions and malignant, rapidly progressing, sometimes lightning-fast course. To control the disease, almost the entire arsenal of anti-inflammatory and cytotoxic drugs existing in medicine is currently used, the use of which has significantly improved the prognosis of patients lives. Current treatments aim to suppress autoimmune inflammation, prevent relapses, and reduce clinical symptoms in order to prevent permanent organ damage. This review highlights the immune mechanisms that prevail in new targeted treatments for SLE.

Keywords: 
therapy
systemic lupus erythematosus
clinical studies
monoclonal antibodies
eculizumab
rituximab
belimumab
obintuzumab
tabalumab
ataxicept
bortezomib
anifrolumab
sifalimumab
rontalizumab



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