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The use of Phenazalgin in the treatment of bladder leukoplakia

DOI: https://doi.org/10.29296/25877305-2021-09-06

A. Korolev, Candidate of Medical Sciences; D. Kostyuchenko S.R. Mirotvortsev University
Clinical Hospital No. 1, Saratov State Medical University

The paper gives the results of a study of the efficacy of Phenazalgin as an uroanalgesic in the preoperative period for bladder leukoplakia (BL) in women. The investigation enrolled 38 patients aged 18 to 46 years (mean age, 22 years), who were diagnosed with BL. In the preoperative period, the patients were divided into 2 equivalent groups: 1) 19 patients who received conservative therapy with hyaluronic acid preparations (as instillations and oral administration) and, if necessary, antibacterial therapy, they took Phenazalgin 100 mg (2 tablets thrice daily for 2 days; if necessary, the cycle was repeated at a one-day interval); 2) during the similar conservative therapy, 19 patients took other non-steroidal anti-inflammatory drugs. Preoperative preparation lasted an average of 7-10 days. The effect of the drug was evaluated before and 3 months after surgery prior to control cystoscopy using the O’Leary/Sant questionnaire, an analog scale for painful BL symptoms and the pelvic Pain and Urgency/frequency Patient Symptom Score).

preoperative preparation
bladder leukoplakia

  1. Zajtsev A.V. Ploskokletochnaja metaplazija urotelija – mnenie zapadnyh ekspertov. Urologija segodnja. 2014; 2 (30): 16 [Zaitsev A.V. Ploskokletochnaya metaplaziya uroteliya – mnenie zapadnykh ekspertov. Urologiya segodnya. 2014; 2 (30): 16 (in Russ.)].
  2. Ozbey I., Aksoy Y., Polat O. et al. Squamous metaplasia of the bladder: findings in 14 patients and review of the literature. Int Urol Nephrol. 1999; 31 (4): 457–61. DOI: 10.1023/a:1007107110222
  3. Frumkin A.P. Tsistoskopicheskij atlas. 2-e izd., dop. i pererab. M.: Miklosh, 1995; 119 s. [Frumkin A.P. Tsistoskopicheskii atlas. 2-e izd., dop. i pererab. M.: Miklosh, 1995; 119 s. (in Russ.)].
  4. Al'-Shukri S.H., Kuz'min I.V., Slesarevskaja M.N. i dr. Vybor taktiki lechenija lejkoplakii mochevogo puzyrja u zhenschin s hronicheskim tsistitom. Urologicheskie vedomosti. 2015; 5 (1): 90–1 [Al’-Shukri S.K., Kuz’min I.V., Slesarevskaya M.N., et al. Vybor taktiki lecheniya leykoplakii mochevogo puzyrya u zhenshchin s khronicheskim tsistitom. Urology reports (St.-Petersburg). 2015; 5 (1): 90–1 (in Russ.)]. DOI: 10.17816/uroved5190-91
  5. Loran O.B., Sinjakova L.A., Kosova V.E. i dr. Lejkoplakija mochevogo puzyrja – novyj vzgljad na problemu. Effektivnaja farmakoterapija. 2008; 20: 50–3 [Loran O.B., Sinyakova L.A., Kosova V.E. et al. Leikoplakiya mochevogo puzyrya – novyi vzglyad na problemu. Effektivnaya farmakoterapiya. 2008; 20: 50–3 (in Russ.)].
  6. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med. 2002; 113 (Suppl 1A): 5–13. DOI: 10.1016/s0002-9343(02)01054-9
  7. Burkhard F.C., Blick N., Studer U.E. Urinary urgency and frequency, and chronic urethral and/or pelvic pain in females. Can doxycycline help? J Urol. 2004; 172 (1): 232–5. DOI: 10.1097/01.ju.0000128698.93305.2e
  8. Patelli E., Mantovani F., Catanzaro M. et al. Urgency-frequency syndrome in women: interstitial cystitis and correlated syndromes. Arch Ital Urol Androl. 1999; 71 (5): 317–20.
  9. Nosov A.K., Reva S.A. Ploskokletochnaja metaplazija urotelija – diagnostika, lechenie i prognoz: vzgljad onkologa. Urologija segodnja. 2014; 2 (30): 14 [Nosov A.K., Reva S.A. Ploskokletochnaya metaplaziya uroteliya – diagnostika, lechenie i prognoz: vzglyad onkologa. Urologiya segodnya. 2014; 2 (30): 14 (in Russ.)].
  10. Fenazalgin®: instruktsija po primeneniju [Phenazalgin: instructions for the use (in Russ.)]. URL: https://www.rlsnet.ru/tn_index_id_96808.htm
  11. Hronicheskij tsistit. UroLajf. [Chronic cystitis. UroLife (in Russ.)]. URL: https://urolife.info/cystitis/khronicheskiy-tsistit