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Hypertrophic cardiomyopathy and pregnancy

DOI: https://doi.org/10.29296/25877305-2021-08-04

Professor G. Ignatenko(1), MD, Corresponding Member of the National Academy of Medical Sciences
of Ukraine, Associate Professor G. Taradin(1, 2), Candidate of Medical Sciences; T. Kugler(1), Candidate of
Medical Sciences (1)M. Gorky Donetsk National Medical University, Donetsk, Donetsk People’s Republic/Ukraine
(2)V.K. Gusak Institute of Emergency and Restorative Surgery, Donetsk, Donetsk People’s Republic/Ukraine

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease. Owing to achievements in medicine over recent decades, the number of pregnancies in women with HCM is increasing and will continue to grow in the future. In most women with HCM, pregnancy proceeds without complications; however, during gestation, the risk of adverse cardiovascular events is increased, especially in symptomatic patients who had a high left ventricular outflow tract gradient, heart failure (HF), or arrhythmias before conception. A high functional class of HF prior to pregnancy is statistically significantly associated with an increased risk of cardiovascular complications during pregnancy or in the postpartum period. In this connection, a detailed cardiovascular system assessment in a patient with HCM is needed to determine the potential risks associated with pregnancy and childbirth and to develop an appropriate therapeutic strategy. The review presents the latest national and international guidelines for the diagnosis and management of pregnant women with HCM. It is emphasized that the clinical manifestations and diagnosis of HCM during pregnancy have a number of features and when prescribing medications, it is necessary to take into account their possible negative impact on the health of the mother and fetus.

obstetrics and gynecology
hypertrophic cardiomyopathy
left ventricular hypertrophy
cardiovascular diseases
heart failure
atrial fibrillation

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