Relationship between comorbidity and sarcopenia: impact on mortality and survival

Download full text PDF

A. Erokhina; Professor E. Golovanova, MD Smolensk State Medical University, Ministry of Health
of Russia

The growth of geriatric syndromes (sarcopenia, senile asthenia, etc.) in the setting of age-related comorbidity has a negative prognostic value for survival of older patients. Early detection of sarcopenia matters muchtoreduce mortality rates among the elderly. Aim. Evaluation of the incidence of comorbidities in patients of mature, elderly and senile age with and without sarcopenia and their impact on mortality and survival rates. Materials and methods. We examined 39 men and 39 women aged between 45 and 89 (average are 60,6±14,3 years). Sarcopenia was diagnosed using the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP) 2010 and the EWGSOP2 2018 recommendations. The comorbidity status was assessed using the Charlson index. Results. Sarcopenia of different severity degrees was detected in 55,7% of the subjects using ultrasound assessment of muscle mass (MM), the incidence of sarcopenia was higher in women that in men (р25 kg/m2. The mean Charlson index (score) was 6,7±0,3 for sarcopenia patients, and 4,0±0,4 for non-sarcopenia patients (р

ultrasound assessment of muscle mass

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

  1. Drozdov A.V. Ljudi starshe 60 let sostavjat bolee chetverti naselenija Rossii k 2030 godu. TASS Elektronnyj resurs [Drozdov A.V. People over 60 will make up more than a quarter of Russia’s population by 2030. TASS Electronic resource. (13 Dec 2018). (in Russ.)]. URL:
  2. Gharacholou S.M., Roger V.L., Lennon R.J. et al. Comparison of frail patients versus non frail patients ≥65 years of age undergoing percutaneous coronary intervention. Am J Cardiol. 2012; 109 (11): 1569–75. DOI: 10.1016/j.amjcard.2012.01.384
  3. Anker S.D., Morley J.E., von Haehling et al. Welcome to the ICD-10 code for sarcopenia. Cachexia, Sarkopenia and Muscle. 2016; 7 (5): 512–4. DOI: 10.1002/jcsm.12147
  4. Charlson M.E., Pompei P., Ales K.L. et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987; 40: 373–83. DOI: 10.1016/0021-9681(87)90171-8
  5. Dumurgier J., Elbaz A., Ducimetière P. et al. Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. BMJ. 2009; 10; 339. DOI: 10.1136/bmj.b4460
  6. Alfonso J.C.J., Gülistan B., Juergen M.B. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019; 48 (1): 16–31. DOI: 10.1093/ageing/afy169
  7. Dodds R.M., Syddall H.E., Cooper R. et al. Grip strength across the life course: normative data from twelve British studies. PLoS One. 2014; 9 (12): 113637. DOI: 10.1371/journal.pone.0113637
  8. Ido A., Nakayama Y., Ishii K. et al. Ultrasound-derived abdominal muscle thickness better detects metabolic syndrome risk in obese patients than skeletal muscle index measured by dual-energy X-ray absorptiometry. PLoS One. 2015; 10 (12): 0143858. DOI: 10.1371/journal.pone.0143858
  9. Arango-Lopera V.E., Arroyo P., Gutiérrez-Robledo L.M. et al. Mortality as an adverse outcome of sarcopenia. J Nutr Health Aging. 2013; 17 (3): 259–62. DOI: 10.1007/s12603-012-0434-0
  10. Bukval'naja N.V., Jakubova L.V., Pitsko D.V. i dr. Sarkopenija: aktsent na obnovlennye rekomendatsii. Lechebnoe delo. 2019; 6 (70): 30–5 [Bukvalnaya N.V., Yakubova L.V., Pitsko D.V. et al. Sarkopenia: focus on the updated recommendations of 2018 EWGSOP-2. Medical business. 2019; 6 (70): 30–5 (in Russ.)].
  11. Noskov S.N., Zavodchikov A.A., Lavruhina A.A. i dr. Klinicheskoe znachenie sarkopenii i miopenii. Klinicheskaja gerontologija. 2015; 5 (6): 46–50 [Noskov S.N., Zavodchikov A.A., Lavrukhina A.A. et al. Clinical significance of sarcopenia and miopenia. Clinical Gerontology. 2015; 5 (6): 46–50 (in Russ.)].
  12. Landi F., Cruz-Jentoft A.J., Liperoti R. et al. Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study. Age Ageing. 2013; 42 (2): 203–9. DOI: 10.1093/ageing/afs194
  13. Grigor'eva I.I., Raskina T.A., Letaeva M.V. i dr. Sarkopenija: osobennosti patogeneza i diagnostiki. Fundamental'naja i klinicheskaja meditsina. 2019; 4 (4): 105–16 [Grigorieva I.I., Raskina T.A., Letaev M.V. et al. Sarcopenia: features of pathogenesis and diagnosis. Fundamental and clinical medicine. 2019; 4 (4): 105–16 (in Russ.)]. DOI: 10.23946/2500-0764-2019-4-4-105-116