Impact of coronavirus infection on cognitive functions in elderly patients
DOI: https://doi.org/10.29296/25877305-2021-06-08
Issue:
6
Year:
2021
The paper reviews information on the etiology and pathogenesis of neurological manifestations in
patients who have had coronavirus infection (COVID-19). It presents the data of studies that have shown that
cognitive impairment is the long-term consequences of the central nervous system. Elderly patients are more
susceptible to neuropsychiatric and cognitive impairment in COVID-19, and in the case of pre-existing
cognitive impairment and dementia after a coronavirus infection; they are observed to have a progression of
these disorders. Early detection of neuropsychological manifestations in persons who have experienced
COVID-19 can lower the risk of subsequent irreversible disorders and further neurocognitive decline.
Nootropic, metabolic, and antioxidant agents with a neuroprotective effect can be recommended for correction
of cognitive impairment in elderly patients.
Keywords:
infectious diseases
neurology
coronavirus infection
COVID-19
central nervous system damage
cognitive impairment
dementia
neuroprotectors
References:
- Bezdetko N.V. Tsitikolin: novoe ob izvestnom. Mezhdunarodnyj nevrologicheskij zhurnal. 2015; 4: 90–4 [Bezdetko N.V. Citikolin: new about known. International Journal of Neurology. 2015; 4: 90–4 (in Russ.)].
- Veselova O.F., Krysenko L.V., Makarova M.V. i dr. Voprosy sovremennoj nauki: monografija. M.: Internauka, 2017; 22. [Veselova O.F., Krysenko L.V., Makarova M.V. et al. Questions of modern Science: monograph. M.: Internauka, 2017; 22 (in Russ.)].
- Gosudarstvennyj reestr lekarstvennyh sredstv [Elektronnyj resurs]. [The State Register of Medicines [Electronic resource] (in Russ.)]. URL: https://grls.rosminzdrav.ru/grls.aspx
- Gromova O.A., Torshin I.Ju., Stahovskaja L.V. i dr. Opyt primenenija meksidola v nevrologicheskoj praktike. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2018; 118 (10): 97–107 [Gromova O.A., Torshin I.Iu., Stakhovskaya L.V. et al. Experience with mexidol in neurological practice. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2018; 118 (10): 97–107 (in Russ.)]. DOI. 10.17116/jnevro201811810197
- Kamchatnov P.R. Korrektsija kognitivnyh i emotsional'nyh rasstrojstv u bol'nyh arterial'noj gipertoniej. Russkij meditsinskij zhurnal. 2019; 7: 28–9 [Kamchatnov P.R. Correction of cognitive and emotional disorders in patients with arterial hypertension. Russian Medical Journal. 2019; 7: 28–9 (in Russ.)].
- Krasnov V.S. Aktovegin v terapii kognitivnyh narushenij u patsientov, perenesshih novuju koronavirusnuju infektsiju COVID-19 (opyt klinicheskih nabljudenij). Effektivnaja farmakoterapija. 2021; 17 (6): 8–12 [Krasnov V.S. Actovegin in the Treatment of Cognitive Impairment in Patients After COVID-19 (Clinical Experience). Effective pharmacotherapy. 2021; 17 (6): 8–12 (in Russ.)]. DOI: 10.33978/2307-3586-2021-17-6-8-12
- Kudlaj D.A., Shirobokov Ja.E., Gladunova E.P. i dr. Diagnostika COVID-19. Sposoby i problemy obnaruzhenija virusa SARSCoV-2 v uslovijah pandemii. Vrach. 2020; 31 (8): 5–10 [Kudlay D., Shirobokov Ya., Gladunova E. et al. Diagnosis of COVID-19. Methods and problems of virus SARS-CoV-2 detection under pandemic conditions. Vrach. 2020; 31 (8): 5–10 (in Russ.)]. DOI: 10.29296/25877305-2020-08-01
- Mazin P.V., Sheshunov I.V., Mazina N.K. Metaanaliticheskaja otsenka klinicheskoj effektivnosti tsitoflavina pri nevrologicheskih zabolevanijah. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2017; 117 (3): 28–39 [Mazin P.V., Sheshunov I.V., Mazina N.K. Meta-analytic assessment of parenteral cytoflavin effectiveness in different neurologic disorders. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017; 117 (3): 28–39 (in Russ.)]. DOI. 10.17116/jnevro20171173128-39
- Pizova N.V., Pizov N.A., Pizov A.V. Kognitivnye narushenija u lits, perenesshih COVID-19. Meditsinskij sovet. 2021; 4: 69–77 [Pizova N.V., Pizov N.A., Pizov A.V. Cognitive impairment in COVID-19 survivors. Meditsinskiy sovet = Medical Council. 2021; 4: 69–77 (in Russ.)]. DOI: 10.21518/2079-701X-2021-4-69-77
- Potupchik T.V., Veselova O.F., Evert L.S. Farmakodinamicheskie aspekty primenenija nekotoryh nootropnyh sredstv pri kognitivnyh narushenijah. Farmateka. 2014; 13: 90–5 [Potupchik T.V., Veselova O.F., Evert L.S. Pharmacodynamic aspects of use of some nootropics in cognitive disorders. Farmateka. 2014; 13: 90–5 (in Russ.)].
- Chukanova E.I., Chukanova A.S. Holina al'fostserat (deletsit) kak odno iz napravlenij lechenija kognitivnyh rasstrojstv. Meditsinskij alfavit. 2016; 14: 12–6 [Chukanova E.I., Chukanova A.S. Choline alfoscerate (delecit) as one of treatment areas of cognitive disorders. Medical Alphabet. 2016; 14: 12–6 (in Russ.)].
- Almeria M., Cejudo J.C., Sotoca J. et al. Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment. Brain Behav Immun Health. 2020; 9: 100163. DOI: 10.1016/j.bbih.2020.100163
- Alonso-Lana S., Marquié M., Ruiz A. et al. Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia. Front Aging Neurosci. 2020; 12: 588872. DOI: 10.3389/fnagi.2020.588872
- Annweiler C., Bourgeais A., Faucon E. et al. Neurological, Cognitive, and Behavioral Disorders during COVID-19: The Nitric Oxide Track. J Am Geriatr Soc. 2020; 68 (9): 1922–3. DOI: 10.1111/jgs.16671
- Beaud V., Crottaz-Herbette S., Dunet V. et al. Pattern of cognitive deficits in severe COVID-19. J Neurol Neurosurg Psychiatry. 2021; 92 (5): 567–8. DOI: 10.1136/jnnp-2020-325173
- Delorme C., Paccoud O., Kas A. et al. COVID-19-related encephalopathy: a case series with brain FDG-positron-emission tomography/computed tomography findings. CoCo-Neurosciences study group and COVID SMIT PSL study group. Eur J Neurol. 2020; 27 (12): 2651–7. DOI: 10.1111/ene.14478
- El H.M., Altintas E., Chapelet G. et al. High depression and anxiety in people with Alzheimer’s disease living in retirement homes during the COVID-19 crisis. Psychiatry Res. 2020; 291: 113294. DOI: 10.1016/j.psychres.2020.113294
- Helms J., Kremer S., Merdji H. et al. Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients. Crit Care. 2020; 24 (1): 491. DOI: 10.1186/s13054-020-03200-1
- Heneka M.T., Golenbock D., Latz E. et al. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther. 2020; 12 (1): 69. DOI: 10.1186/s13195-020-00640-3
- Malkova A., Kudlay D., Kudryavtsev I. et al. Immunogenetic Predictors of Severe COVID-19. Vaccines. 2021; 9: 211. DOI: 10.3390/vaccines9030211
- Miners S., Kehoe P.G., Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimers Res Ther. 2020; 12 (1): 170. DOI: 10.1186/s13195-020-00744-w
- Negrini F., Ferrario I., Mazziotti D. et al. Neuropsychological Features of Severe Hospitalized Coronavirus Disease 2019 Patients at Clinical Stability and Clues for Postacute Rehabilitation. Arch Phys Med Rehabil. 2021; 102 (1): 155–8. DOI: 10.1016/j.apmr.2020.09.376
- Riordan P., Stika M., Goldberg J. et al. COVID-19 and clinical neuropsychology: A review of neuropsychological literature on acute and chronic pulmonary disease. Clin Neuropsychol. 2020; 34 (7–8): 1480–97. DOI: 10.1080/13854046.2020.1810325
- Sepúlveda-Loyola W., Rodriguez-Sánchez I., Pérez-Rodriguez P. et al. Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations. J Nutr Health Aging. 2020; 24 (9): 938–47. DOI: 10.1007/s12603-020-1469-2
- Serrano-Castro P.J., Estivill-Torrús G., Cabezudo-Garcia P. et al. Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? Neurologia. 2020; 35 (4): 245–51. DOI: 10.1016/j.nrl.2020.04.002
- Soltani Z.H., Gorji A., Ghadiri T.A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View. Mol Neurobiol. 2021; 58 (2): 536–49. DOI: 10.1007/s12035-020-02149-0
- Stefano G.B., Ptacek R., Ptackova H. et al. Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce ‘Brain Fog’ and Results in Behavioral Changes that Favor Viral Survival. Med Sci Monit. 2021; 27: e930886. DOI: 10.12659/MSM.930886
- Varatharaj A., Thomas N., Ellul M.A. et al. CoroNerve Study Group. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. 2020; 7 (10): 875–82. DOI: 10.1016/S2215-0366(20)30287-X
- Xiong J., Lipsitz O., Nasri F. et al. Impact of COVID-19 pandemic on mental health in the general population: A systematic review. J Affect Disord. 2020; 277: 55–64. DOI: 10.1016/j.jad.2020.08.001
- Zhou H., Lu S., Chen J., et al. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020; 129: 98–102. DOI: 10.1016/j.jpsychires.2020.06.022
- Zhou J., Liu C., Sun Y. et al. Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain Behav Immun. 2021; 91: 383–92. DOI: 10.1016/j.bbi.2020.10.019