Brain-derived neurotrophic factor as an indicator of central nervous system diseases

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Yu. Zykova(1); L. Evert(2), MD; T. Potupchik(3), Candidate of Medical Sciences (1)OOO «Medicine
of Computer Technologies» Medical and Diagnostic Clinic, Krasnoyarsk (2)Research Institute for Medical
Problems of the North, Federal Research Center “Krasnoyarsk Research Center, Siberian Branch, Russian
Academy of Sciences (3)Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health
of Russia

The paper reviews the literature on the involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of many diseases of the central nervous system. It presents data of the studies showing a correlation between BDNF deficiency in the brain and blood tissues and neurodegenerative diseases, such as Alzheimer’s, Huntington’s, Parkinson’s diseases, hypoxia, headaches and migraines, and psychoemotional disorders. It is shown that BDNF can serve as a marker for predicting the course of diseases and evaluating the efficiency of treatment.

brain-derived neurotrophic factor
neurodegenerative diseases
psychoemotional disorders

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