CLINICAL FEATURES OF EXTRA-INTESTINAL MANIFESTATIONS AND OPTIMIZATION OF TREATMENT FOR CELIAC DISEASE

DOI: https://doi.org/10.29296/25877305-2020-12-10
Download full text PDF
Issue: 
12
Year: 
2020

S. Ledensova(1); N. Gulyaev(2), MD; P. Seliverstov(3), Candidate of Medical Sciences (1)City
Polyclinic No.76, Saint-Petersburg (2)Third Central Military Clinical Hospital named after A.A. Vishnevsky’
of the Ministry of Defense of the Russian Federation, Moscow region, g/o Krasnogorsk, Novy (3)North-Western
State Medical University named after I.I. Mechnikov of the Ministry of Health of the Russian Federation,
Saint-Petersburg

The article deals with the study of prevalence of extraintestinal manifestations in young adults with celiac disease after the transition to an adult polyclinic network. During the study the features of clinical manifestations are revealed and the degree of their intensity depending on the patients adherence to a gluten-free diet is studied. The results of therapeutic interventions aimed at treating the manifestations of the underlying disease are presented. The peculiarities of patients follow-up after their transition to adult polyclinic network are discussed. Moreover, the article concerns the preventive measures focused on the treatment of the celiac disease extraintestinal manifestations.

Keywords: 
celiac disease
extraintestinal manifestations
prevention
celiac disease in adults
gluten-free diet



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Bel'mer S.V. Epidemiologija tseliakii: fakty i vyvody. Lechaschij vrach. 2013; 1: 16–9 [Belmer S.V. Epidemiology of celiakia: facts and conclusions. Lechaschii Vrach. 2013; 1: 16–9 (in Russ.)].
  2. Porodenko N.V., Skibitskij V.V., Zapevina V.V. i dr. Tipichnye i atipichnye formy tseliakii: trudnosti diagnostiki. Kubanskij meditsinskij vestnik. 2018; 25 (1): 189–94 [Porodenko N.V., Skibitskiy V.V., Zapevina V.V. et al. Typical and atypical forms of celiac desease: difficulties in the diagnosis. Kuban Scientific Medical Bulletin. 2018; 25 (1): 189–94 (in Russ.)]. https://doi.org/10.25207/1608-6228-2018-25-1-189-194
  3. Bykova S.V., Parfenov A.I., Sabel'nikova E.A. Epidemiologija tseliakii v mire. Al'manah klinicheskoj meditsiny. 2018; 46 (1): 23–31 [Bykova S.V., Parfenov A.I., Sabel’nikova E.A. Global epidemiology of celiac disease. Almanac of Clinical Medicine. 2018; 46 (1): 23–31 (in Russ.)]. https://doi.org/10.18786/2072-0505-2018-46-1-23-31
  4. Vserossijskij konsensus po diagnostike i lecheniju tseliakii u detej i vzroslyh. Al'manah klinicheskoj meditsiny. 2016; 44 (6): 661–8 [The Russian consensus on diagnosis and treatment of coeliac disease in children and adults. Almanac of Clinical Medicine. 2016; 44 (6): 661–8 (in Russ.)]. https://doi.org/10.18786/2072-0505-2016-44-6-661-688
  5. Oreshko L.S. Istoricheskie i klinicheskie aspekty tseliakii. SPb, 2011; 108 s. [Oreshko L.S. Historical and clinical aspects of celiac disease. SPb, 2011; 108 r. (in Russ.)].
  6. Bai J.C., Fried M., Corazza G.R. et al. World Gastroenterology Organisation global guide-lines on celiac disease. J Clin Gastroenterol. 2013; 47 (2): 121–6. https://doi.org/10.1097/MCG.0b013e31827a6f83
  7. Schuppan D., Junker Y., Barisani D. Celiac disease: from pathogenesis to novel therapies. Gastroenterology. 2009; 137 (6): 1912–33. https://doi.org/10.1053/j.gastro.2009.09.008
  8. Oreshko L.S. Tseliakija vzroslyh: osobennosti patogeneza, klinicheskih projavlenij, diagnostiki, lechenija i profilaktiki oslozhnenij. Dis. … d-ra med. nauk. SPb, 2008; 291 s. [Oreshko L.S. Celiac disease in adults: features of pathogenesis, clinical manifestations, diagnosis, treatment and prevention of complications. Diss. dokt. med. nauk. Sankt-Peterburg, 2008; 291 p. (in Russ.)].
  9. Oreshko L.S., Solov'eva E. A. Anemicheskie projavlenija pri sindrome mal'absorbtsija i ih korrektsija. Gastroenterologija Sankt-Peterburga. 2016; 1–2: 2–5. [Oreshko L.S., Solovyeva E.A. Anemic manifestations in malabsorption syndrome and their correction. Gastroenterology of St. Petersburg. 2016; 1–2: 2–5 (in Russ.)]. URL: https://www.elibrary.ru/download/elibrary_28963584_13551003.pdf
  10. Smyth D.J., Plagnol V., Walker N.M. et al. Shared and distinct genetic variants in type 1 di-abetes and celiac disease. N Engl J Med. 2008; 359 (26): 2767–77. https://doi.org/10.1056/NEJMoa0807917
  11. Al-Toma A., Volta U., Auricchio R. et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019; 7 (5): 583–613. https://doi.org/10.1177/2050640619844125
  12. Rubio-Tapia A., Hill I.D., Kelly C.P. et al. ACG clinical guide-lines: diagnosis and management of celiac disease. Am J Gastroenterol. 2013; 108 (5): 656–76; quiz 677. https://doi.org/10.1038/ajg.2013.79
  13. Kochergin N.A., Samgin M.A., Monahov S.A. i dr. Dermatologicheskij indeks akne. Esteticheskaja meditsina. 2004; 3 (1): 62–5 [Kochergin N.A., Samgin M.A., Monakhov S.A. et al. Dermatologic index acne. Esteticheskaya meditsina. 2004; 3 (1): 62–5 (in Russ.)].
  14. Pigarova E.A., Rozhinskaja L.Ja., Belaja Zh.E. i dr. Klinicheskie rekomendatsii Rossijskoj assotsiatsii endokrinologov po diagnostike, lecheniju i profilaktike defitsita vitamina D u vzroslyh. Problemy endokrinologii. 2016 62 (4): 60–84 [Pigarova E.A., Rozhinskaya L.Y., Belaya Z.E. et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemy endocrinologii. 2016 62 (4): 60–84 (in Russ.)]. URL: https://cyberleninka.ru/article/n/klinicheskie-rekomendatsii-rossiyskoy-assotsiatsii-endokrinologov-po-diagnostike-lecheniyu-i-profilaktike-defitsita-vitamina-d-u/viewer
  15. Federal'nye klinicheskie rekomendatsii. Dermatovenerologija 2015: Bolezni kozhi. Infektsii, peredavaemye polovym putem. 5-e izd., pererab. i dop. M.: Delovoj ekspress, 2016; 768 s. [Federal’nye klinicheskie rekomendacii. Dermatovenerologiya 2015: Bolezni kozhi. Infekcii, peredavaemye polovym putem.5-e izd., pererab. i dop. M.: Delovoj ekspress, 2016. 768 s. (in Russ.)]. URL: https://cnikvi.ru/docs/2335_maket_30.pdf